A5028328732- Dialysis and Renal Disease Management
- Diabetes Treatment and Management
- Electrolyte and hormonal disorders
- Ion Transport and Channel Regulation
- Retinal and Optic Conditions
- Drug-Induced Hepatotoxicity and Protection
- Renal and Vascular Pathologies
- Pharmacological Effects and Toxicity Studies
- Retinal Imaging and Analysis
- Iron Metabolism and Disorders
- Hormonal Regulation and Hypertension
- Renal Diseases and Glomerulopathies
- Drug Transport and Resistance Mechanisms
- Blood Pressure and Hypertension Studies
- Potassium and Related Disorders
- Renal function and acid-base balance
- Vasculitis and related conditions
- Metabolism and Genetic Disorders
- Abdominal vascular conditions and treatments
- Sodium Intake and Health
- Hemoglobinopathies and Related Disorders
- Migraine and Headache Studies
- Eicosanoids and Hypertension Pharmacology
- Retinal Diseases and Treatments
- Monoclonal and Polyclonal Antibodies Research
Chungbuk National University Hospital
2012-2024
Chungbuk National University
2012-2024
Yonsei University
2023-2024
Asan Medical Center
2003-2021
University of Ulsan
2003-2021
Soonchunhyang University Hospital
2021
Hallym University Sacred Heart Hospital
2021
Ulsan College
2021
Cancer Research And Biostatistics
2021
Ajou University
2021
In this study, a one-step immunoassay for porcine epidemic diarrhea virus (PEDV) based on Fv-antibodies and switching peptides was developed, the assay results of PEDV were obtained by just mixing samples without any further reaction or washing steps. The with binding affinity to spike protein screened from Fv-antibody library using receptor-binding domain (RBD) as screening probe. Screened affinities RBD antigen expressed, constants (KD) calculated be 83-142 nM. detection configured...
Current practice guidelines recommend alkali therapy in patients with chronic kidney disease (CKD) and metabolic acidosis to prevent complications.This study aims investigate the effect of oral sodium bicarbonate supplementation on progression renal function nutritional indices predialysis advanced CKD.Forty stage 5 CKD (estimated glomerular filtration rate, eGFR <15 mL/min per 1.73 m 2) 40 4 (eGFR 15 30 2 ) who had a total CO2 less than 22 mEq/L were assigned into treatment group or control...
This study aims to compare the classification performance of statistical models on highly imbalanced kidney data. The health examination cohort database provided by National Health Insurance Service in Korea is utilized build with various machine learning methods. glomerular filtration rate (GFR) used diagnose chronic disease (CKD). It calculated using Modification Diet Renal Disease method and classified into five stages (1, 2, 3A 3B, 4, 5). Different CKD based estimated GFR are considered...
Ceftriaxone is widely used in patients for the treatment of serious gram-negative infections.Ceftriaxone can induce some potential side effects, including neurotoxicity, however, nonconvulsive status epilepticus has rarely been reported.We report a case acute reversible neurotoxicity associated with ceftriaxone.A 65-yr-old woman chronic kidney disease developed altered consciousness during ceftriaxone urinary tract infection.The electroencephalogram demonstrated continuous bursts...
To explore the effect of renal function on pharmacokinetic (PK) and pharmacodynamic (PD) profile safety enavogliflozin, a selective sodium-glucose cotransporter 2 (SGLT2) inhibitor, in patients with type diabetes mellitus (T2DM).
Background:The converging epidemics of tuberculosis (TB) and end-stage renal disease (ESRD) have generated a significant public health burden, however, previous studies been limited to small number patients.This nationwide cohort study aimed assess the rate developing active TB among patients receiving dialysis for ESRD.Methods: The Korean national insurance database was used identify new-onset ESRD during 2004-2013, who were propensity score matched an equivalent non-dialysis subjects from...
Enhanced heat shock protein-70 (HSP-70) expression in the lungs is associated with attenuated acute lung injury (ALI) a sepsis model. Chronic kidney disease (CKD) significantly contributes to poor prognosis of patients sepsis. This study examined relationship between sepsis-induced ALI severity and altered HSP-70 CKD. Experimental rats underwent sham operation (control group) or 5/6 nephrectomy (CKD group). Sepsis was induced cecal ligation puncture (CLP). Laboratory tests harvest were...
Background/Aims: Podocytes play an important role in maintaining the glomerular filtration barrier and formation of slit diaphragm. Podocyte loss is associated with chronic kidney disease progression, but it not clear whether urinary podocyte proteins urine reflect clinical extent damage. We investigated correlation between amounts renal function albuminuria. Methods: The study enrolled 33 patients diabetic or measured podocytes using Western blotting. Urinary were according to density bands...
The numbers of patients on dialysis and their life expectancies are increasing. Reduced renal function is associated with an increased risk cancer, but the cancer incidence sites in compared those general population require further investigation. We investigated incidences various cancers Korea used national health insurance data to identify that should be screened clinics.We accessed Korean National Health Insurance Database excerpted using International Classification Disease codes for...
Inhibitors of the epithermal growth factor receptor (EGFR) were screened from an autodisplayed Fv-antibody library using anti-EGF antibody. The was expressed on outer membrane Escherichia coli, which corresponds to heavy chain VH region immunoglobulin G. constructed by randomizing CDR3 regions (11 amino acid residues) site-directed mutagenesis. Using antibody as a screening probe, sequences (CDR3 region) with binding affinity library. These considered have similar chemical properties EGF,...
CAPD) and Auto mated Peritoneal Dialysis (APD)This study aimed to investigate the influence of different peritoneal dialysis regimens on blood pressure control, diurnal pattern left ventricular hypertrophy in patients dialysis.Forty-four undergoing were enrolled into study.Patients treated with dialysis: 26 continuous ambulatory (CAPD) 18 automated (APD).All performed 24-hour monitoring (ABPM) echocardiography.Echocardiography was for measurement cardiac parameters calculation mass index...
(1) Background: Oxidative stress and inflammation are associated with higher risk of chronic kidney disease (CKD). Serum ferritin concentrations correlate total iron levels systemic inflammation. (2) Methods: This study was cross-sectionally designed, based on the 2010-2012 Korean National Health Nutrition Examination Survey (KNHANES). According to values, 13,462 participants (6082 men 7380 women) were categorized into normal- high-ferritin groups (cut-off points: 200 ng/mL in men, 150...
Acute kidney injury (AKI) is common in patients with sepsis and causes renal ischemia. Glucagon-like peptide-1 (GLP-1) protects the vascular system kidney, GLP-1 receptor (GLP-1R) expressed kidney. Renal GLP-1R activity decreased chronic disease (CKD), but increased by inflammatory response; however, effect of AKI on expression unknown. We investigated role assessing cortex animals AKI-related sepsis, CKD, CKD-with-sepsis. generated a model CKD 5/6 nephrectomy, induced cecal perforation,...
Background The requirement for subsequent cholecystectomy in patients with gallbladder situ after endoscopic removal of stones from the common bile duct (CBD) is controversial. aims this study were to assess gallbladder-related symptoms, and identify who develop symptoms CBD stones. Methods Of 241 following CBD, 146 (78 men 68 women; mean age 69±13 years, range 20â93) a follow-up time more than three months without elective enrolled study. Fifty-nine had (single 27 multiple 32) 87 entry...
End-stage renal disease (ESRD) patients on hemodialysis have poor nutritional status and associated problems such as inflammation sarcopenia. Blood urea nitrogen (BUN) is an important measure of uremic toxins, reduction a marker efficacy. However, low protein diet for lower BUN could aggravate malnutrition in patients, optimal pre-dialysis not defined. We investigated the association with patients' comorbidities relationship between serum albumin nutrient marker. Among 67 average pre-...
Erythropoiesis-stimulating Agents and Anemia in Patients with Non-dialytic Chronic Kidney DiseaseAnemia is common patients advanced chronic kidney disease (CKD).Though erythropoiesis-stimulating agents (ESAs) have been strongly endorsed guidelines, it of particular financial interest.Recently, the reimbursement ESAs non-dialytic was started by Korean National Health Insurance System.Thus, we investigated impact on anemia care CKD patients.Medical records (estimated GFR < 30 mL/min/1.73m 2 )...
Chronic kidney disease (CKD) is strongly associated with cardiovascular and a significant risk factor for increased morbidity mortality. In contrast, GLP-1 receptor (GLP-1R) activation has been shown to confer both renal protection, though its relationship CKD myocardial ischemia/reperfusion (MI/R) remains poorly understood. Here, we investigated changes in GLP-1R expression the rat model MI/R.Male Sprague Dawley rats 5/6 nephrectomy were used as of MI/R. For ischemia, left coronary artery...
We describe a patient with severe hypernatremia and uremia caused by paranoid adipsia who was treated successfully hydration hemodialysis.A previously healthy 40-year-old woman developed the idea that her water poisoned, so she refused to drink any water.On admission, blood urea nitrogen 208 mg/dL, creatinine 4.90 serum osmolality 452 mOsm/L, sodium 172 mEq/L, urine specific gravity ≥1.030, 698 sodium/potassium/chloride 34/85.6/8mEq/L.We diagnosed uremic encephalopathy started intravenous...
Recombinant activated coagulation factor VII (rFVIIa) is known to be effective in the management of acquired deficiencies and platelet function defects. But recently, rFVIIa has been successfully used treat ongoing bleeding disseminated intravascular coagulopathy (DIC) condition. The patient reported here was suspected suffering from toxic hepatitis on admission. After percutaneous liver biopsy, occurred did not stop even after right hepatic artery embolization. developed a severe hemorrhage...