A5100627825- Retinal Diseases and Treatments
- Nonlinear Differential Equations Analysis
- Glaucoma and retinal disorders
- Nonlinear Partial Differential Equations
- Advanced Mathematical Modeling in Engineering
- Ocular Diseases and Behçet’s Syndrome
- Retinal and Optic Conditions
- Retinal Development and Disorders
- Retinal and Macular Surgery
- Retinal Imaging and Analysis
- Differential Equations and Boundary Problems
- Differential Equations and Numerical Methods
- Intraocular Surgery and Lenses
- Ocular Infections and Treatments
- Stability and Controllability of Differential Equations
- Ophthalmology and Visual Impairment Studies
- Chronic Kidney Disease and Diabetes
- Corneal surgery and disorders
- Spectral Theory in Mathematical Physics
- Ocular Surface and Contact Lens
- Breast Implant and Reconstruction
- Systemic Lupus Erythematosus Research
- Ocular Disorders and Treatments
- Genetic and Kidney Cyst Diseases
- Dialysis and Renal Disease Management
Seoul National University Hospital
2014-2025
Dankook University Hospital
2012-2025
Seoul National University
2011-2024
Chinese University of Hong Kong
2024
University of Hong Kong
2024
Pusan National University
2011-2023
Dankook University
2010-2023
Chungnam National University
2007-2023
Dongshin University
2022-2023
National University College
2008-2022
Abstract We have developed a highly sensitive microarray protein chip, ProteoChip, coated with ProLinker™, novel calixcrown derivatives bifunctional coupling property that permits efficient immobilization of capture proteins on solid matrixes and makes high‐throughput analysis protein‐protein interactions possible. The quartz crystal microbalance showed both monoclonal antibody (mAb) antigen (Ag) bound to the gold film sensor surface ProLinker™ B it is useful for studies Ab‐Ag interactions....
A bstract Purpose: To determine the effect of Ahmed glaucoma valve (AGV) implantation on corneal endothelial cells. Methods: valves were implanted in 30 eyes patients with refractory glaucoma. Corneal cell density and shape was prospectively evaluated both subject fellow each patient. specular microscopy performed superior, superotemporal, superonasal central areas before at 1, 6 12 months after surgery. Results: statistically significant decrease average observed postoperatively compared...
To investigate changes of inner retinal layers and optic nerve head (ONH) in patients with dry age-related macular degeneration (AMD) demonstrate the pattern these changes.A total 76 eyes classified as having AMD control were included. Ophthalmologic evaluations included best-corrected visual acuity (BCVA) assessment, spectral-domain optical coherence tomography (SD-OCT), Humphrey field (VF) test. The drusen area volume determined using automated algorithm SD-OCT software. Macular ganglion...
The extracellular signal regulated kinase (ERK1 and ERK2) transduction pathways play a critical role in cell proliferation. Hyperactivation of the ERK proteins either through increased expression membrane-bound growth factor receptors or genetic mutations upstream is thought to be involved pathogenesis many human cancers. Thus, targeted inhibition signaling viewed as potential approach prevent cancer Currently, no specific inhibitors exist. Moreover, most lack specificity because they target...
<i>Background/Aim:</i> Endothelial dysfunction due to reduced nitric oxide (NO) availability precedes the development of atherosclerosis. Asymmetric dimethylarginine (ADMA), an endogenous inhibitor NO synthase, is not only a cause endothelial dysfunction, but also predictor cardiovascular outcome in end-stage renal disease (ESRD) patients on hemodialysis (HD). α-Lipoic acid (ALA), strong antioxidant, increases NO-mediated vasodilation diabetic patients. We investigated whether...
The H9N2 subtype low pathogenic avian influenza is one of the most prevalent diseases worldwide, and was first documented in 1996 Korea.This disease caused serious economic loss Korea's poultry industry.In order to develop an oil-based inactivated vaccine, a virus that had been isolated 2001 (A/chicken/Korea/01310/ 2001) selected based on its pathogenic, antigenic, genetic properties.However, animal experiments, efficacy vaccine found be very without concentration antigen (2 7 2 10...
<i>Background:</i> The phospholipase A<sub>2</sub> receptor (PLA2R) is a major antigen found in patients with idiopathic membranous nephropathy (MN). relationship of genetic polymorphisms PLA2R the susceptibility and clinical outcomes this disease unknown. <i>Methods:</i> We studied 199 MN followed up for 3.7 ± 3.2 years. enrolled 33 secondary 356 subjects normal blood pressure no proteinuria. single nucleotide (SNPs) were genotyped....
The major components of tea may be significantly influenced according to the type fermentation, and consequently effects different teas will differ. We examined whether green fermented with Aquilariae Lignum (fGT) shows a stronger anti-diabetic effect than unfermented (GT) on mice 2 diabetes. To evaluate anti-obesity fGT, we assessed body weight, fecal excretion, serum leptin levels, exocrine pancreatic zymogen granule contents, periovarian fat weight adiponectin contents. Blood glucose...
Age-related macular degeneration (AMD) can lead to irreversible central vision loss in the elderly. Although large number of growth factor pathways, including vascular endothelial (VEGF), has been implicated pathogenesis AMD, no study directly assessed whole proteomic composition aqueous humor (AH) among AMD patients. The AH contains proteins secreted from anterior segment tissue, and these may play an important role AMD. Thus, comparisons between profiles patients non-AMD controls...
Abstract Background To date, no genetic analysis of inherited retinal disease (IRD) using whole-exome sequencing (WES) has been conducted in a large-scale Korean cohort. The aim this study was to characterise the profile IRD patients Korea WES. Methods We performed comprehensive molecular testing 168 unrelated potential pathogenicity candidate variants assessed American College Medical Genetics and Genomics Association for Molecular Pathology variant interpretation guidelines, silico...
Intraocular foreign bodies (IOFBs) are critical ophthalmic emergencies that require urgent diagnosis and treatment to prevent blindness or globe loss. This study aimed examine the various clinical presentations of IOFBs, determine prognostic factors for final visual outcomes, establish diagnostic protocols, update strategies patients with IOFBs. We retrospectively reviewed IOFBs between 2005 2019. The mean age was 46.7 years, most common mechanism injury hammering (32.7%). location retina...
ABSTRACT Background Leber congenital amaurosis (LCA), the most severe form of inherited retinal dystrophy, is a rare, heterogeneous, genetic eye disease associated with visual impairment. RPE65, one causative genes for LCA, encodes retinoid isomerohydrolase, an enzyme that plays critical role in regenerating pigment photoreceptor cells. Methods Exome sequencing (ES) was performed on patient suspected LCA. Results Here, we report 33‐year‐old male diagnosed RPE65 ‐related LCA caused by...
Membrane contact sites are recognized across eukaryotic systems as important nanostructures. Endoplasmic reticulum (ER)-plasma membrane (PM) (EPCS) involved in excitation-contraction coupling, signaling, and plant responses to stress. In this report, we perform a multiscale structural analysis of Arabidopsis EPCS that combines live cell imaging, quantitative transmission electron microscopy (TEM) tomography over developmental gradient. To place the context entire cortical ER, examined green...
<h3>Aims</h3> To investigate the choroidal thickness changes in eyes with retinal vein occlusion (RVO) and to determine effect of an intravitreal dexamethasone implant (Ozurdex) on thickness. <h3>Methods</h3> This study comprised 47 patients diagnosed unilateral, RVO-associated macular oedema (MO) treated Ozurdex. Baseline subfoveal (SFCT) central (CMT) RVO were compared those normal contralateral eyes; serial this parameter evaluated at 1, 3 5 months after Ozurdex injection. The correlation...
Oxidative stress has been implicated as critical pathogenic factors contributing to the etiology of diabetic retinopathy and other retinal diseases. This study investigated antioxidative effect ascorbic acid astaxanthin on ARPE-19 cells within an oxidative model induced by common biological sources reactive oxygen species (ROS). Hydrogen peroxide (H2O2) at concentrations 0.1–0.8 mM 20–100 mJ/cm2 ultraviolet B (UVB) were treated cells. Cell viability intracellular ROS level changes measured....
Silicone oil (SO) is widely used as a long-term intravitreal tamponading agent for rhegmatogenous retinal detachment (RRD) repair. This study investigated the structural changes of foveal microvasculature using optical coherence tomography angiography (OCTA) in patients with RRD treated vitrectomy and SO tamponade. Thirty-eight unilateral who were tamponade followed up ≥3 months after removal included. En face OCTA images obtained avascular zone (FAZ) area vascular density (VD) compared...
<b><i>Background:</i></b> Endoplasmic reticulum (ER) stress induced by urinary albumin plays an important role in tubulointerstitial injury. We have shown that albumin-induced ER is regulated through reactive oxygen species (ROS)-c-Src kinase-mTOR signaling pathways. postulated peroxisome proliferator-activated receptor-γ (PPAR-γ) might also act as upstream molecule between c-Src kinase and mTOR. It has been suggested AMP-activated protein (AMPK) involved attenuation...
Idiopathic hypereosinophilia (IHE)/idiopathic hypereosinophilic syndrome (IHES) has been defined by a persistent elevation of the blood eosinophil count exceeding 1.5×103/μL, without evidence reactive or clonal causes. While T-cell clonality assessment recommended for unexplained hypereosinophilia, this approach is not often applied to routine practice in clinic. We hypothesized that would exist subset IHE/IHES patients. aimed investigate candidate mutations and explore role proliferation....
The aim of the study was to determine short-term real-world safety and efficacy intravitreal brolucizumab injections in Korean patients with neovascular age-related macular degeneration (nAMD).This multicenter retrospective involved 294 eyes (treatment naïve 20 eye [6.8%] nontreatment 274 [93.2%]) 290 from 13 hospitals or retinal centers South Korea. Patients nAMD who received injection(s) between April 1 November 30, 2021, a follow-up ≥1 month, were included. Primary outcomes safety,...