A5058252132- Renal Transplantation Outcomes and Treatments
- Renal Diseases and Glomerulopathies
- Renal and Vascular Pathologies
- Organ Transplantation Techniques and Outcomes
- Neurological Complications and Syndromes
- Organ Donation and Transplantation
- Chronic Kidney Disease and Diabetes
- Transplantation: Methods and Outcomes
- Dialysis and Renal Disease Management
- Cytomegalovirus and herpesvirus research
- Endoplasmic Reticulum Stress and Disease
- Polyomavirus and related diseases
- Pharmacological Effects and Toxicity Studies
- Liver Disease and Transplantation
- Acute Kidney Injury Research
- Cardiac, Anesthesia and Surgical Outcomes
- Hepatitis C virus research
- Diabetes Treatment and Management
- Metabolism, Diabetes, and Cancer
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Pregnancy and Medication Impact
- Electrolyte and hormonal disorders
- Liver Disease Diagnosis and Treatment
- Gout, Hyperuricemia, Uric Acid
- Mast cells and histamine
Asan Medical Center
2016-2025
University of Ulsan
2016-2025
Ulsan College
2016-2025
Park University
2022
Eulji University
2011
It has been suggested that endoplasmic reticulum (ER) stress facilitates fibrotic remodeling. Therefore, modulation of ER may serve as one the possible therapeutic approaches to renal fibrosis. We examined whether and how activation AMP-activated protein kinase (AMPK) suppressed induced by chemical inducers [tunicamycin (TM) thapsigargin (TG)] also nonchemical in tubular HK-2 cells. further investigated vivo effects AMPK on Western blot analysis, immunofluorescence, small interfering (si)RNA...
Introduction: Although studies have suggested that metabolic risk profiles are prognostic factors in kidney transplantation recipients (KTRs), the value of fatty liver, a known surrogate risk, KTRs remain to be elucidated. The objective this study was investigate association between non-invasive liver biomarkers used assess hepatic steatotic and fibrotic burdens graft outcomes KTRs. Methods: A total 3,092 patients who underwent deceased or living donor (KT) January 2000 December 2022 were...
Clinically, it may be appropriate to subdivide patients with stage 3 chronic kidney disease (CKD) into two subgroups, as they show different risks for outcomes. This study evaluated the proportion of CKD who progressed 4 or 5 over 10 years and independent predictors progression renal dysfunction. It sought validate whether should subdivided.This retrospective cohort enrolled 347 between January 1997 December 1999, were followed up through June 2010. The baseline clinical characteristics...
Endoplasmic reticulum (ER) stress is emerging as an important factor in the development of organ fibrosis. Therefore, modulation ER may serve one possible therapeutic approaches to renal SIRT1, a class III histone deacetylase, has been found exert beneficial effects kidney diseases. However, it largely unknown whether and how SIRT1 suppresses stress. We postulated that upregulation would suppress through induction heme oxygenase-1 (HO-1) thioredoxin.HK-2 tubular cells, experimental mouse...
Endoplasmic reticulum (ER) stress is increasingly identified as modulator of fibrosis. Losartan, an angiotensin II receptor blocker, has been widely used the first choice treatment in chronic renal diseases. We postulated that anti-fibrotic effect losartan mediated through inhibition ER via SIRT1 (silent mating type information regulation 2 homolog 1) hemeoxygenase-1 (HO-1)/thioredoxin pathway. Renal tubular cells, tunicamycin (TM)-induced stress, and unilateral ureteral obstruction (UUO)...
<b><i>Background/Aims:</i></b> Additional validation study was warranted to confirm the clinical significance of C score, which recently added Oxford classification for immunoglobulin A nephropathy (IgAN). <b><i>Methods:</i></b> We performed a multicenter retrospective cohort in four hospitals Korea. Patients who had biopsied glomeruli less than eight or inadequate follow-up information were excluded. Clinicopathologic parameters, including...
New-onset diabetes mellitus after transplantation (NODAT) is a serious complication following renal transplantation. The aim of this study was to identify the risk factors for development NODAT in Korean transplant patients.Recipients who underwent living donor kidney between January 2009 and April 2012 at Asan Medical Center were reviewed. Diagnosis defined according American Diabetes Association criteria.A total 418 patients enrolled. diagnosed 85 (20.4 %) within 1 year. By multivariate...
BACKGROUND:BK nephropathy (BKN) affects graft function and increases the risk of failure. The reduction immunosuppression is main treatment for BKN. However, acute rejection may develop following reduction, data regarding factors during post-reduction period are insufficient. MATERIAL AND METHODS:Of 758 patients who received a kidney transplantation (KT) between 2008 2011, 79 underwent as BKN were enrolled. after identified using multivariate logistic regression analysis. RESULTS:During...
Abstract Background Recurrent focal segmental glomerulosclerosis (FSGS) after kidney transplantation (KT) is a serious complication and significant risk factor for graft failure. However, there no clear evidence of the effectiveness pre-transplant treatment using plasmapheresis (PP) or rituximab in preventing post-operative FSGS recurrence KT. Methods This single-center retrospective study included 99 adult patients with biopsy-proven primary who underwent KT between 2007 2018. The were...
Abstract Background Parvovirus B19 is a small, non‐enveloped, single‐stranded DNA virus with special affinity for the erythroid progenitor cells of bone marrow. The first case parvovirus infection in kidney transplant recipient ( KTR ) was reported 1986. Data on risk factors and specific clinical characteristics remain insufficient. Methods We screened 602 s using polymerase chain reaction PCR from January 1990 to April 2016, patients positive results were compared those age‐ gender‐matched...
Hyperparathyroidism is common in patients with chronic kidney disease reduced renal function and has been observed after transplantation. The optimal treatment for cases which hyperparathyroidism persists transplantation not determined.This retrospective study included 83 tertiary who underwent between 2000 2018 at a single center Korea. Sixty-four parathyroidectomy 19 were treated cinacalcet following Biochemical parameters clinical outcomes compared the two groups.Serum calcium parathyroid...
With the recent update to Oxford classification for allograft IgA nephropathy (IgAN), additional investigations on clinical significance of updated components are warranted. We performed a retrospective cohort study at two tertiary hospitals. Kidney transplant recipients diagnosed with IgAN were included in after review by specialized pathologists. applied and determined MEST-C scores patients. The main outcome was death-censored graft failure within 10 years establishment diagnosis assessed...
<i>Background:</i> Rituximab, an anti-CD20 antibody, effectively depletes B lymphocytes. It is not clear whether the use of conventional doses mycophenolate mofetil (MMF), methylprednisolone and tacrolimus as maintenance immunosuppression in rituximab-treated kidney transplantation associated with increased risk. <i>Methods:</i> We retrospectively evaluated 67 patients who underwent HLA-sensitized or ABO-incompatible living donor after one dose rituximab (200 500 mg)...
Background The American Gastroenterological Association and European for the Study of Liver recommend that hepatitis B surface antigen (HBsAg)–negative core antibody (anti-HBc)–positive patients who receive immunosuppression should be monitored virus (HBV) infection regardless (anti-HBs) status. However, anti-HBs may provide protection against infection. To investigate whether presence in addition to anti-HBc confers protection, we classified HBsAg(−) kidney transplantation (KT) into 4...
The prognosis of patients with allograft IgA nephropathy (IgAN) requires further investigation. We performed a bicenter retrospective cohort study on kidney transplant recipients diagnosed IgAN in biopsy. Recipients without but known before transplantation were included as the control group. investigated associations between clinicopathological characteristics, including crescents, and risk death-censored graft failure. In total, 1256 both pre- posttransplant stages included. Among them, 559...
Kidney transplantation (KT) reportedly provides a significant survival advantage over dialysis in diabetic patients. However, KT outcome patients compared with that non-diabetic remains controversial. In addition, owing to recent improvements the outcomes of and management cardiovascular diseases, it is necessary analyze recently performed
BACKGROUND One-year renal function after kidney transplantation (KT) classified by the Kidney Disease: Improving Global Outcomes (KDIGO) chronic disease (CKD) staging has been reported to be associated with graft survival. However, outcomes of KT are improving. Therefore, distribution and prognostic value 1-year estimated glomerular filtration rate (eGFR) in recently performed transplants were re-evaluated this study. MATERIAL AND METHODS We reviewed all patients who received between 2008...
Febuxostat, a nonpurine xanthine oxidase, is known to be effective and safe, even in patients with chronic kidney disease. However, there are insufficient data about the efficacy safety of febuxostat transplant patients.We reviewed medical records all who were prescribed between August 2012 May 2015 at Asan Medical Center Seoul, Korea. The results evaluated. To compare febuxostat, benzbromarone or allopurinol for more than 1 year during same period also reviewed.Thirty-one included this...
ABO-incompatible (ABOi) kidney transplantation (KT) has become a routine procedure with graft survival rates comparable to those of ABO-compatible KT. However, the clinical significance isoagglutinin titre in ABOi KT remains uncertain. Therefore, this study, we analysed outcomes according baseline and post-operative titre.All patients who received between 2009 2013 were reviewed followed up until December 2016. The classified (<1:128 or ≥1:128) rebound (<1:16 ≥1:16), compared.Patients high...