Background and Purpose Neuroinflammation through microglial activation is involved in the pathogenesis of neurodegenerative diseases including P arkinson's disease ( PD ), a major disorder characterized by dopaminergic neuronal death substantia nigra. We examined our novel synthetic compound VSC 2 for its anti‐inflammatory properties towards development therapy. Experimental Approach tested effects on production various NF‐κB ‐dependent proinflammatory molecules N rf2‐dependent antioxidant...

Clinically, it may be appropriate to subdivide patients with stage 3 chronic kidney disease (CKD) into two subgroups, as they show different risks for outcomes. This study evaluated the proportion of CKD who progressed 4 or 5 over 10 years and independent predictors progression renal dysfunction. It sought validate whether should subdivided.This retrospective cohort enrolled 347 between January 1997 December 1999, were followed up through June 2010. The baseline clinical characteristics...

Among the various visuospatial dysfunctions, deficits of stereopsis could be associated with Parkinson’s disease. We examined differences in regional gray matter volume between disease patients normal and abnormal to delineate possible anatomical correlate stereopsis. Stereopsis was assessed using Titmus test 35 drug-naive Voxel-based morphometry utilized assess regionally specific 16 19 Patients had a significant reduction right extrastriate visual cortex compared (P<0.05, corrected for...

Purpose: The purpose of this study was to assess the influence blue light-filtering intraocular lenses (IOL) on peripapillary retinal nerve fiber layer (RNFL) thickness measurements by spectral-domain (SD) optical coherence tomography (OCT).Methods: This prospective included 50 eyes patients. Patients were randomly assigned receive either a IOL (acrysof IQ (SN60WF) [Alcon]) or clear (Tecnis (Z9003) [AMO]). RNFL measured using Cirrus SD OCT before and 8 weeks after cataract surgery....

In most cases, patients admitted to an intensive care unit (ICU) have suffered from severe trauma, undergone major surgery or been treated for a serious medical illness. Although they often experience more intense pain than general ward patients, are frequently unable communicate their experiences health providers, thus preventing accurate assessment and treatment of pain. If appropriate measures not taken treat in critically ill stress response sympathetic overstimulation can lead...

The prevalence of a history shoulder complaints is higher in patients with Parkinson's disease (PD) than healthy individuals. aims this study were to evaluate PD ultrasonography (US) and identify the relationship between US findings motor signs PD. Thirty-three completed disability questionnaire, musculoskeletal examination, shoulder. Twenty-two had abnormal findings. Tendon tearing was most common finding (22/22), supraspinatus tendon site involved (15/22). Patients significantly longer...

Resiniferatoxin (RTX) is a potent analog of capsaicin and activates transient receptor potential (TRP) vanilloid type (TRPV) 1. In the current study, we investigated preventive effect perineural RTX on development cold hypersensitivity induced by spinal nerve ligation (SNL) in rats. Furthermore, examined association between expression level TRPV1, TRP ankyrin (TRPA) 1 melastatin (TRPM) 8 dorsal root ganglion (DRG) after SNL. pretreatment prevented SNL-induced to mechanical, thermal, stimuli....

Background . The cervical epidural space can be detected by the loss of resistance (LOR) technique which is commonly performed using air. However, this air has been associated with a high false-positive LOR rate during interlaminar steroid injections (CIESIs). Objective We investigated whether detection contrast medium might reduce on first attempt. Methods obtained data retrospectively. A total 79 patients were divided into two groups according to technique. Groups 1 and 2 underwent CIESI...

Most cardinal motor signs in Parkinson’s disease (PD) are more pronounced on one side than the other. Unusually, type of sign is found while other contralateral side, so-called dissociation signs. The aims this study were to determine frequency and clinical characteristics group. To end, including Unified Disease Rating Scale, Mini-Mental State Examination, Non-Motor Symptom Questionnaire Frontal Lobe Assessment Battery analyzed for 411 patients during consecutive follow-up visits....

Although remifentanil is used widely by many clinicians during general anesthesia, there are recent evidences of opioid-induced hyperalgesia as an adverse effect. This study aimed to determine if intraoperative infusion caused increased pain the postoperative period in patients who underwent a thyroidectomy. A total 7511 aged ≥ 20 years, thyroidectomy between January 2009 and December 2013 at Asan Medical Center were retrospectively analyzed. Enrolled divided into 2 groups: group N (no only...

(1) Background: The activated partial thromboplastin time (APTT)- based clot waveform analysis (CWA) quantitatively extends information obtained from the APTT through its derivatives. However, pre-analytical variables including reagent effects on CWA parameters are poorly understood and must be standardized as a potential diagnostic assay. (2) Methods: was first analysed with patient samples to understand lot variation in three common reagents: Pathromtin SL, Actin FS, FSL. A total of 1055...

Sugammadex has shown faster reversal of steroidal neuromuscular blockade (NMB) than neostigmine, a traditional agent for NMB, even in the intense block phase. This efficiency is possible because unique mechanism action by encapsulating NMB molecules. Therefore, with use sugammadex, we can also expect to avoid direct interactions cholinergic system and its subsequent side effects, which are disadvantages drugs. However, despite these benefits US Food Drug Administration (FDA) approval 2015,...

Orthostatic headache is a key symptom of intracranial hypotension; however, not all orthostatic headaches are caused by cerebrospinal fluid leaks leading to hypotension. We report here the unusual case 68‐year‐old man presenting with in which compression C3 spinal nerve root metastatic tumor invasion may contribute development his headache.

서 론 대장암은 최근 우리나라에서도 급속히 증가하는 추세이며[1]소화관에 발생하는 다른 종류의 종양보다 비교적 진행이 느리고 효과적인 치료 방법도 잘 확립되어 있다 [2].따라서 선별검사로 전구병변을 조기에 진단하여 치료하면 대장암으로 인한 사망률을 줄일 수 [3,4]

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with the selective loss of motor neurons in brain, brain stem, and spinal cord. A number mutants human gene for superoxide dismutase 1 (SOD1) have been shown to cause familial ALS as result gain-of-function toxicity by an unknown mechanism. In this study, we show that glyceraldehyde-3-phosphate dehydrogenase (GAPDH) functions critical mediator apoptotic cell death signaling cascade induced ALS-associated G93A mutant SOD1...

This multicenter retrospective study aimed to investigate the prognostic value of CA-125 elimination rate constant K (KELIM) in EOC patients who received platinum-based chemotherapy followed by PARP inhibitors, either upfront or interval treatment settings.

Rationale: The prone position is the most commonly required during spinal surgery. Decreasing lumbar lordosis necessary to facilitate accessibility of surgical field. And this can affect hemodynamic circulation patients. Jackson spine table one preferred methods, known have minimal effects on cardiac function. Patient concerns: We report a case sudden arrhythmia that developed using table. It occurred 30 minutes after positional change. Diagnoses: Arrhythmia showed bizarre P and QRS waves....

Reactive oxygen species (ROS), which are also generated in a normal condition certain quantities, large quantities by ischemia or resupply at the time of reperfusion and not reduced antioxidant systems body, eventually causing injury tissues [1]. In this study, we investigated whether thiopental propofol, intravenous anesthetics, decrease endothelium ROS evaluated mechanism for endothelium-dependent relaxation rabbit abdominal aortas. All experiments study were done after obtaining...

Background : From medical care perspective regarding HIV, early detection of HIV is critical in effectively managing its sequelae. People who are aware the fact that they infected with significantly reduce high risk behaviors, thus limiting transmission to others compared individuals w...