A5100723554- Parkinson's Disease Mechanisms and Treatments
- Gastric Cancer Management and Outcomes
- Thyroid Cancer Diagnosis and Treatment
- Gastrointestinal Tumor Research and Treatment
- Metastasis and carcinoma case studies
- Neurological disorders and treatments
- Cancer, Lipids, and Metabolism
- Breast Cancer Treatment Studies
- Inflammatory Biomarkers in Disease Prognosis
- Cancer Risks and Factors
- Esophageal and GI Pathology
- Diverse Approaches in Healthcare and Education Studies
- Head and Neck Anomalies
- Prostate Cancer Treatment and Research
- Radiomics and Machine Learning in Medical Imaging
- Restless Legs Syndrome Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Diagnosis and Treatment
- Gallbladder and Bile Duct Disorders
- Pancreatic and Hepatic Oncology Research
- Botulinum Toxin and Related Neurological Disorders
- Breast Lesions and Carcinomas
- Thyroid and Parathyroid Surgery
- Estrogen and related hormone effects
- Gastrointestinal disorders and treatments
Gyeongsang National University Hospital
2013-2024
Duksung Women's University
2024
Gyeongsang National University
2010-2023
Weatherford College
2021
Yonsei University
2021
University of Ulsan
2013-2018
Asan Medical Center
2014-2018
Ulsan College
2014-2018
Yang Hospital
2015-2017
Korea University
2012
Abstract BACKGROUND: Trastuzumab is part of the standard treatment for patients with human epidermal growth factor receptor 2 (HER‐2)‐positive breast cancer, but not all respond to trastuzumab. Altered microRNA (miR) expression levels in cancer cells have been correlated prognosis and response chemotherapy. The authors this report hypothesized that altered miR plasma are associated sensitivity trastuzumab HER‐2 positive cancer. METHODS: Quantitative reverse transcriptase‐polymerase chain...
Abstract In vitro expanded CNS precursors could provide a renewable source of dopamine (DA) neurons for cell therapy in Parkinson's disease. Functional DA have been derived previously from early midbrain precursors. Here we demonstrate the ability Nurr1, nuclear orphan receptor essential neuron development vivo , to induce dopaminergic differentiation naïve . Independent gestational age or brain region origin, Nurr1‐induced expressed markers and exhibited depolarization‐evoked release...
Gastric and colonic alpha-synuclein immunoreactivity has been reported in patients with Parkinson's disease (PD). However, enteric also healthy individuals.We aimed to investigate the utility of from gastric mucosal tissues obtained by routine endoscopy detect PD, correlate pathological burden motor nonmotor features PD.We recruited 104 study subjects, consisting 38 13 probable multiple system atrophy (MSA), 53 controls. endoscopic gastroduodenoscopy colonoscopy were assessed using...
Abstract Background We aimed to identify whether neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte (PLR) are more useful predictors after initial intention treat than at the time of diagnosis. Methods collected medical data 533 patients. The results peripheral blood sampling before primary treatments were labeled as cohort, those obtained between 24 36 months treatment defined 2nd cohort. Delayed metastasis has been distant 2 years treatment, survival outcome was estimated...
Breast malignancy remains one of the most common causes cancer‑associated mortalities among women. MicroRNA (miR)‑221 and miR‑222 are homologous miRs have a substantial impact on cancer progression. In present study, regulatory mechanisms miR‑221/222 its target annexin A3 (ANXA3) in breast cells were investigated. tissue samples collected to evaluate expression patterns levels cell lines tissues according clinical characteristics. The increased or decreased compared with normal line subtype....
Background: Because laparoscopic liver resection (LLR) has a steep learning curve, analyzing experience is important for trainees. Several authors have described the curve of LLR, without comparing curves between major and minor LLR. Methods: Perioperative data were retrieved from medical records 170 consecutive patients who underwent LLR by single surgeon at tertiary hospital. Learning generated compared using cumulative sum control charts moving average. Results: Major was performed in 96...
In this study, we found that expression and secretion of galectin‐3 (GAL‐3) were upregulated by amyloid‐β42 (Aβ42) exposure in human umbilical cord blood‐derived mesenchymal stem cell (hUCB‐MSC) without death. Aβ42‐exposed rat primary cortical neuronal cells co‐treated with recombinant GAL‐3 protected from death a dose‐dependent manner. hUCB‐MSCs cocultured or the neuroblastoma line, SH‐SY5Y Transwell chamber. Coculture reduced neurons cells. This neuroprotective effect was significantly...
While extended cholecystectomy is recommended for T2 gallbladder cancer (GBC), the role of hepatic resection GBC unclear. This study aimed to identify necessity in patients with GBC. Data 81 histopathologically proven who underwent surgical between January 1999 and December 2017 were enrolled from a retrospective database. Of these, 36 had peritoneal-side (T2a) tumors 45 hepatic-side (T2b) tumors. To optimal management method, classified into group (n = 44, T2a/T2b 20/24) non-hepatic 37,...
Clinical outcomes of papillary thyroid microcarcinoma (PTMC) vary. In general, age at diagnosis is an independent prognostic factor in conventional carcinoma. However, it unclear patients PTMC. The purpose this study was to identify clinicopathologic features and factors PTMC according patients' age.Five hundred twenty-seven who received surgery diagnosed as having PTC between January 2001 December 2009 were included. clinical data retrospectively analyzed.We divided the into two groups;...
α-Synucleinopathy in the brain is neuropathological hallmark of Parkinson's disease (PD). However, functional impact α-synucleinopathy enteric nervous system remains unknown. We aim to evaluate association between gastrointestinal (GI) dysfunction and α-synuclein (αSYN) pathology stomach colon PD patients controls, as well investigate αSYN GI tract future risk.A total 35 52 neurologically intact subjects were enrolled this study. Endoscopic biopsies performed, then immunohistochemical...
There is little data about the performance of multiplex rapid antigen tests (RATs) on detection SARS-CoV-2, influenza A (Flu A), and B B). This study to evaluate Panbio COVID-19/Flu A&B panel (Abbott Diagnostics, Korea) analyze factors influencing its sensitivity.
Purpose: Excess weight and obesity have been associated with numerous diseases including thyroid cancer, but the relationship has weak.The objective of this study was to evaluate body sizes on nodules in healthy Korean population.Methods: A total 7,763 persons who underwent a health examination our center were included study.The epidemiologic factors, size ultrasound results reviewed.We investigated effects presence malignancy.Results: The incidence 20.6%.In group found nodules, mean height,...
The aim of this study is to evaluate whether the associations between clinicopathologic factors papillary thyroid microcarcinoma (PTMC), especially tumor size, and subclinical central lymph node metastasis (LNM) are dependent on patient age.The medical records 428 patients who underwent surgery for PTC measuring ≤1 cm were reviewed. All clinically negative thyroidectomy with unilateral or bilateral dissection. Univariate multivariate analyses performed identify associated LNM.Central LNM was...
The prognostic role of serum estrogen level in breast cancer patients is unclear. We investigated the importance preoperative estradiol (E2) postmenopausal women according to their receptor (ER) status.The medical records 313 who underwent surgery between 2006 and 2008 at a single institution were retrospectively evaluated. Patients received neoadjuvant chemotherapy, synchronous bilateral cancer, or those with metastasis diagnosis excluded. Serum E2 follicular stimulating hormone (FSH)...
Background: Parkinson's disease (PD) is a common neurodegenerative disorder, characterized by clinical symptomatology involving both motor and non-motor symptoms. Motor complications associated with long-term dopaminergic treatment include fluctuations levodopa-induced dyskinesia (LID), which may have major impact on the quality of life. The features onset time in course are heterogeneous, etiology remains unknown. Objective: We aimed to identify genomic variants development LID at 5 years...
The incidence of papillary thyroid carcinoma (PTC) is increasing worldwide. Positive associations between indices body size and cancer have been reported. However, the relationships to severities and/or behaviors are uncertain.We performed a retrospective analysis data patients who underwent total thyroidectomy due PTC. epidemiologic factor pathologic report after operation were determined based on chart review. these parameters assessed.Positive association mass index T stage was found, but...