A5023915332- Mesenchymal stem cell research
- Tissue Engineering and Regenerative Medicine
- Neonatal Respiratory Health Research
- Hematopoietic Stem Cell Transplantation
- Neurogenesis and neuroplasticity mechanisms
- RNA Interference and Gene Delivery
- Osteoarthritis Treatment and Mechanisms
- Electrospun Nanofibers in Biomedical Applications
- Alzheimer's disease research and treatments
- MicroRNA in disease regulation
- Galectins and Cancer Biology
- Spinal Cord Injury Research
- Nerve injury and regeneration
- Macrophage Migration Inhibitory Factor
- Urological Disorders and Treatments
- Telomeres, Telomerase, and Senescence
- Cancer Cells and Metastasis
- Hair Growth and Disorders
- Cancer-related molecular mechanisms research
- Pulmonary Hypertension Research and Treatments
- Congenital Diaphragmatic Hernia Studies
- Angiogenesis and VEGF in Cancer
- Signaling Pathways in Disease
- Nuclear Receptors and Signaling
- Wnt/β-catenin signaling in development and cancer
Medipost (South Korea)
2013-2022
Biomedical Research Institute
2013-2020
Ulsan College
1999-2016
University of Ulsan
1999-2016
Hanyang University Medical Center
2013
Wonkwang University
2012
Sungkyunkwan University
2010
Various source-derived mesenchymal stem cells (MSCs) have been considered for cell therapeutics in incurable diseases. To characterize MSCs from different sources, we compared human bone marrow (BM), adipose tissue (AT), and umbilical cord blood-derived (UCB-MSCs) surface antigen expression, differentiation ability, proliferation capacity, clonality, tolerance aging, paracrine activity. Although tissues similar levels of immunosuppressive activity, UCB-MSCs had the highest rate significantly...
Abstract Adenovirus-mediated gene therapies against brain tumors have been limited by the difficulty in tracking glioma cells infiltrating parenchyma. Human umbilical cord blood–derived mesenchymal stem (UCB-MSC) are particularly attractive for clinical use cell-based therapies. In present study, we evaluated tumor targeting properties and antitumor effects of UCB-MSCs as delivery vehicles therapy. We efficiently engineered to deliver a secretable trimeric form necrosis factor-related...
Recent evidence suggests mesenchymal stem cells (MSCs) can downmodulate bleomycin-induced lung injury, and umbilical cord blood (UCB) is a promising source for human MSCs. This study examined whether intratracheal or intraperitoneal transplantation of UCB-derived MSCs attenuate hyperoxia-induced injury in immunocompetent newborn rats. Wild-type Sprague-Dawley rats were randomly exposed to 95% oxygen air from birth. In the groups, single dose PKH26-labeled was administered either...
Brain-derived neurotrophic factor (BDNF) plays an important role in the differentiation, development, and survival of neural stem cells. In this study, we analyzed its effects on stimulation human umbilical cord blood-derived mesenchymal cells terms their potential to differentiate into neuron-like cells, characteristics, molecular mechanisms involved. The treatment with induction medium (NIM) BDNF generated more that were produced stronger expression neural-lineage markers than treated NIM...
Clinical trials of gene therapy using a viral delivery system for glioma have been limited. Recently, stem cells as the vehicles therapeutic agents has emerged new treatment strategy malignant brain tumors. In this study, we used human umbilical cord blood–derived mesenchymal (UCB-MSCs) with glioma-targeting capabilities, and modified interleukin-12 (IL-12p40N220Q; IL-12M) novel gene. We also engineered UCB-MSCs to secret IL-12M (UCB-MSC-IL12M) via tetrameric cell-permeable peptide...
Irradiation is a standard therapy for gliomas and many other cancers. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) one of the most promising candidates cancer gene therapy. Here, we show that tumor irradiation enhances tropism human umbilical cord blood-derived mesenchymal stem cells (UCB-MSCs) therapeutic effect TRAIL delivered by UCB-MSCs. The sequential treatment with followed TRAIL-secreting UCB-MSCs (MSC-TRAIL) synergistically enhanced apoptosis in either...
Abstract Introduction Stem cell transplantation is a promising therapeutic strategy for the treatment of stroke. Mesenchymal stem cells (MSCs) are potential source clinical application because they can be easily obtained and cultivated with high proliferative capacity. The safety efficacy therapy depends on mode administration. To determine intrathecal administration MSCs by lumbar puncture (LP), we administrated human umbilical cord blood-derived (hUCB-MSCs) intrathecally into spinal or...
Increasing evidence indicates that the secretome of mesenchymal stem cells (MSCs) has therapeutic potential for treatment various diseases, including cartilage disorders. However, paracrine mechanisms underlying repair by MSCs are poorly understood. Here, we show human umbilical cord blood-derived (hUCB-MSCs) promoted differentiation chondroprogenitor action. This effect hUCB-MSCs on was increased with synovial fluid (SF) obtained from osteoarthritis (OA) patients but decreased SF fracture...
Our previous studies demonstrated that transplantation of human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs) into the hippocampus a transgenic mouse model Alzheimer's disease (AD) reduced amyloid-β (Aβ) plaques and enhanced cognitive function through paracrine action. Due to limited life span hUCB-MSCs after their transplantation, extension hUCB-MSC efficacy was essential for AD treatment. In this study, we show repeated cisterna magna injections activated endogenous...
Intratracheal transplantation of human umbilical cord blood (UCB)-derived mesenchymal stem cells (MSCs) attenuates the hyperoxia-induced neonatal lung injury. The aim this preclinical translation study was to optimize dose UCB-derived MSCs in attenuating injury newborn rats. Newborn Sprague-Dawley rats were randomly exposed hyperoxia (95% oxygen) or normoxia after birth for 14 days. Three different doses MSCs, 5 × 10 3 (HT1), 4 (HT2), and (HT3), delivered intratracheally at postnatal day (P)...
Mesenchymal stem cells (MSCs) are of particular interest for the treatment immune-related diseases due to their immunosuppressive capacity. Here, we show that Small MSCs primed with Hypoxia and Calcium ions (SHC-MSCs) exhibit enhanced stemness immunomodulatory functions treating allogeneic conflicts. Compared naïve cultured human umbilical cord blood-derived MSCs, SHC-MSCs were resistant passage-dependent senescence mediated via monocyte chemoattractant protein-1 p53/p21 cascade secreted...
Abstract Therapeutic applications of mesenchymal stem cells (MSCs) for treating various diseases have increased in recent years. To ensure that treatment is effective, an adequate MSC dosage should be determined before these are used therapeutic purposes. obtain a sufficient number applications, MSCs must expanded long-term cell culture, which inevitably triggers cellular senescence. In this study, we investigated the surface markers human umbilical cord blood-derived (hUCB-MSCs) associated...
Interstitial cystitis (IC) is a syndrome characterized by urinary urgency, frequency, pelvic pain, and nocturia in the absence of bacterial infection or identifiable pathology. IC devastating disease that certainly decreases quality life. However, causes remain unknown no effective treatments cures have been developed. This study evaluated therapeutic potency using human umbilical cord-blood-derived mesenchymal stem cells (UCB-MSCs) to treat rat model investigate its responsible molecular...
Alzheimer's disease (AD) is an incurable neurodegenerative characterised clinically by learning and memory impairments. Amyloid beta (Aβ) peptide-induced synaptic dysfunction a pathological process associated with early-stage AD. Here, we show that paracrine action of human umbilical cord blood-derived-mesenchymal stem cells (hUCB-MSCs) protects the hippocampus from synaptic-density loss in vitro vivo AD models. To identify factors underlying this rescue effect, analysed hUCB-MSCs' secretome...
The administration of mesenchymal stem cells (MSCs) was shown to attenuate overt as well early diabetic nephropathy in rodents, but the underlying mechanism this beneficial effect is largely unknown. Inflammation and mitochondrial dysfunction are major pathogenic factors nephropathy. In study, we found that repeated MSCs prevents albuminuria injury tubular epithelial (TECs), an important element progression nephropathy, by improving function. expression M1 macrophage markers significantly...
Our observations indicate that umbilical cord blood-derived mesenchymal stem cells (UCB-MSCs) have a strong migration capacity toward the human glioma cell line, U-87 MG, LN18, U138, and U251, when compared to several other cancer lines. In order identify soluble factors function attract UCB-MSCs, we used cytokine antibody arrays screen changed cytokines in conditioned media from MG cells. Among these, interleukin-8 (IL-8) growth-related oncogene (GRO-alpha) enhanced UCB-MSC migration....