Human umbilical cord blood (UCB)-derived mesenchymal stem cells (MSCs) attenuate hyperoxic neonatal lung injury primarily through anti-inflammatory effects. We hypothesized that intratracheal transplantation of human UCB-derived MSCs could Escherichia coli (E. coli)-induced acute (ALI) in mice by suppressing the inflammatory response.Eight-week-old male ICR were randomized to control or ALI groups. was induced E. instillation. Three-hours after instillation, MSCs, fibroblasts...

Intratracheal transplantation of human umbilical cord blood (UCB)-derived mesenchymal stem cells (MSCs) protects against neonatal hyperoxic lung injury by a paracrine rather than regenerative mechanism. However, the role factors produced MSCs, such as vascular endothelial growth factor (VEGF), has not been delineated. This study examined whether VEGF secreted MSCs plays pivotal in protecting injury. was knocked down UCB-derived transfection with small interfering RNA specific for VEGF. The...

Periventricular-intraventricular hemorrhage (PV-IVH) is a major cause of neurological disabilities in preterm newborns.This study aimed to determine the perinatal factors associated with PV-IVH.We conducted retrospective case-control from infants born at ≤34 weeks gestation and admitted Neonatal Intensive Care Units Seoul National University Children's Hospital Bundang between June 2003 December 2007.Neonates no cranial sonographic data or transferred other centers after three days age were...

There were many reports of longitudinal changes in the causative organisms neonatal sepsis Western countries but few Asia. We aimed to study trends epidemiology at Seoul National University Children's Hospital (SNUCH), a tertiary center Korea, and compared results previous studies countries. The medical records all neonates who hospitalized SNUCH from 1996 2005 with positive blood cultures reviewed. also findings 16-yr (1980-1995). One hundred forty-nine identified 147 episodes 134 infants....

Purpose: This study was performed to evaluate the long-term effects and safety of intratracheal (IT) transplantation human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs) in neonatal hyperoxic lung injury at postnatal day (P)70 a rat model.Materials Methods: Newborn Sprague Dawley pups were subjected 14 days hyperoxia (90% oxygen) within 10 hours after birth allowed recover room air until sacrificed P70.In groups, hUCB-MSCs (5×10 5 ) administered intratracheally P5.At P70,...

ABSTRACT: The effect of infertility on the psychological well‐being couples has been subject increasing attention in recent years. frustration a relatively young age (ie, their fourth decades) provokes not only anxiety and depression but also negative effects relationships. objective this study was to evaluate diagnosis male men themselves fertile female spouses. prospective cross‐sectional consisted 264 participants, 72 males diagnosed with nonobstructive azoospermia (NOA) spouses 60...

Objective MicroRNAs (miRNAs) regulate gene expression during the peri-implantation period. The purpose of this study was to investigate whether genetic polymorphisms in four miRNAs associated with fetal or placental development play roles idiopathic recurrent pregnancy loss (RPL) Korean females. Study design A case-control involving 225 controls and 387 women at least two consecutively losses between 1999 2012 performed. genotypes miRNA polymorphisms, including miR-27a rs895819, miR-423...

Continuous renal replacement therapy (CRRT) is becoming the treatment of choice for supporting critically ill pediatric patients. However, a few studies present have reported CRRT use and outcome in neonates weighing less than 3 kg. The aim this study to describe clinical application, outcome, complications small neonates.A retrospective review was performed 8 neonatal patients who underwent at least 24 hours pumped venovenous Samsung Medical Center Seoul, Korea, between March 2007 July...

Abstract Background Faced with extremely low fertility rates and increasing numbers of low‐birthweight births in K orea, we examined the factors affecting mortality very‐low‐birthweight ( VLBW ) infants orea. Methods A survey was conducted 91 93 hospitals providing neonatal intensive care orea 2009. Data included information on number unit NICU beds, medical workforce, resources , birth death. Results There approximately one per 4888 births, bed 355 mechanical ventilator 739 incubator 327...

We demonstrate a simple method to tune the electrical properties of graphene synthesized by chemical vapor deposition (CVD) with dual-side doping – bottom-side doping<italic>via</italic>substrate modification NH₂-SAMs and top-side diethylenetriamine (DETA) molecules.

We performed this study to evaluate the safety of permissive hypotension management in extremely low birth weight infants (ELBWIs).Medical records all inborn ELBWIs admitted Samsung Medical Center from January 2004 December 2008 were reviewed retrospectively. Of a total 261 ELBWIs, 47 (18%) required treatment for (group T), 110 (42%) remained normotensive N), and 104 (40%) experienced more than one episode without P) during first 72 hours life. Treatment included inotropic support and/or...

Meconium obstruction (MO) of prematurity can result in increased morbidity or mortality and prolonged hospitalization if not diagnosed treated appropriately.The aims our study were to identify the incidence risk factors associated with MO review treatment outcomes.A retrospective analysis was undertaken 101 extremely low birth weight infants (ELBWIs) who born between January 1, 2007, April 2009, at Seoul National University Hospital. Prenatal neonatal compared control groups. The outcomes...

We report the integration of SrRuO3, one most widely used oxide electrode materials in functional heterostructures, with silicon using molecular-beam epitaxy and an SrTiO3 buffer layer. The resulting SrRuO3 film has a rocking curve full width at half maximum 0.01°, resistivity room temperature 250 μΩ cm, residual ratio (ρ300 Kρ4 K) 11, paramagnetic-to-ferromagnetic transition ∼160 K. These structural, electrical, magnetic properties compare favorably to best reported values for films on...

Hemophagocytic lymphohistiocytosis (HLH) occurs in the primary form (genetic or familial) secondary (acquired). The familial of HLH (FHL) is a potentially fatal autosomal recessive disorder that because constitutional defects cell-mediated cytotoxicity. Here, we report neonatal case type 2 FHL (FHL2) involved novel frameshift mutation. Clinically, newborn presented with severe sepsis-like features and required mechanical ventilation continuous venovenous hemodiafiltration. Flow cytometry...

The use of amplitude-integrated electroencephalography (aEEG) is increasing during the neonatal intensive care preterm infants.This prospective study was designed to assess factors that affect maturation aEEG activity in infants with a gestational age (GA) <32 weeks.aEEGs cerebral function monitoring were performed weekly infants, and recordings evaluated scored degree continuity, sleep-wake cycling, amplitude lower border. Subjects any following conditions excluded: intraventricular...

A retropharyngeal abscess is a rare disease entity in young infants but can develop after nasopharyngeal viral infection. Group B Streptococcus and Staphylococcus aureus are the most common pathogens infants, however, Mycobacterium tuberculosis very rare. We report case of coinfection with S. M. infant presenting respiratory symptoms due to upper airway obstruction. Usually tuberculous abscesses caused by direct invasion bacteria from spine via anterior longitudinal ligament spine. However,...

&lt;b&gt;&lt;i&gt;Introduction:&lt;/i&gt;&lt;/b&gt; Although patent ductus arteriosus (PDA) has been implicated to play a role in the development of cerebral ischemia and intraventricular hemorrhage (IVH) through steal phenomenon, there is conflicting data on impact PDA size blood flow (CBF). Cerebral autoregulation brain’s innate protective mechanism maintain constant CBF despite changes pressure, it unclear if influenced by hemodynamics. &lt;b&gt;&lt;i&gt;Objective:&lt;/i&gt;&lt;/b&gt; To...

1α,25-dihydroxyvitamin D3 [1,25(OH)2D3] is capable of inhibiting the proliferation acute myelogenous leukemia (AML). However, toxicity hypercalcemia has limited use 1,25(OH)2D3 in clinical trials. We have evaluated 11 synthesized vitamin analogs for their ability to inhibit clonal growth HL-60 myeloid leukemic cells. Among analogs, HY-11 (code name) showed most potent antileukemic activity with 2.5x10−6 M IC50, however, it did not affect cellular normal peripheral blood mononuclear cells...

Purpose : To identify the short-term clinical outcomes of late preterm infants and to test hypothesis that have more problems during early postnatal period than term infants. Methods One hundred [gestational age (GA) 34+0-36+6 weeks] same number (GA 37+0-41+6 weeks) were randomly selected from 289 825 born in Seoul National University Bundang Hospital between January 2007 December 2007, their electronic medical records reviewed analyzed. Results Compared infants, had significantly such as...