A5065602761- Neuroblastoma Research and Treatments
- Hematopoietic Stem Cell Transplantation
- Acute Lymphoblastic Leukemia research
- Mesenchymal stem cell research
- Glioma Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Childhood Cancer Survivors' Quality of Life
- Cancer therapeutics and mechanisms
- Immune Cell Function and Interaction
- Lymphoma Diagnosis and Treatment
- Cytomegalovirus and herpesvirus research
- Cell death mechanisms and regulation
- Cancer, Hypoxia, and Metabolism
- Neonatal Health and Biochemistry
- Autoimmune and Inflammatory Disorders Research
- Immunodeficiency and Autoimmune Disorders
- Testicular diseases and treatments
- Neutropenia and Cancer Infections
- Neuroendocrine Tumor Research Advances
- Chronic Myeloid Leukemia Treatments
- Parvovirus B19 Infection Studies
- Polyomavirus and related diseases
- Hemoglobinopathies and Related Disorders
- Transplantation: Methods and Outcomes
- Sarcoma Diagnosis and Treatment
Samsung Medical Center
2015-2024
Sungkyunkwan University
2015-2024
National Hemophilia Foundation
2024
Samsung (South Korea)
2002-2021
Korea University Medical Center
2021
Seoul St. Mary's Hospital
2011-2017
Chonnam National University Hwasun Hospital
2011-2017
Catholic University of Korea
2011-2017
Gachon University Gil Medical Center
2017
Chonnam National University Hospital
2017
Highlights•IFN-γ priming enhances the immunosuppressive properties of human MSCs in vitro and vivo models.•IFN-γ induces IDO expression via JAK/STAT1 signaling pathway, but TLR3 activation does not.•Cell therapy using primed with IFN-γ could be highly effective treating allogeneic diseases, including GVHD.It is necessary to improve function mesenchymal stem cells (MSCs) maximize their treatment potential beyond what currently achieved cell studies naïve heterogeneous MSCs. The preclinical...
We analyzed a nationwide registry of pediatric patients with hemophagocytic lymphohistiocytosis (HLH) in Korea to assess the clinical and genetic features treatment outcomes HLH.The Histiocytosis Working Party retrospectively data on 251 diagnosed HLH between 1996 2011.In study cohort, 25 cases were categorized familial HLH, 64 presumed secondary 162 unspecified HLH. Of 217 evaluable patients, 91 (42%) had concomitant Epstein-Barr virus infection. 238 central nervous system (CNS)...
Culture of mesenchymal stem cells (MSCs) under ambient conditions does not replicate the low oxygen environment normal physiological or pathological states and can result in cellular impairment during culture. To overcome these limitations, we explored effect hypoxia (1 % O
Although AKT ⁄ protein kinase B is constitutively active in nonsmall cell lung cancer (NSCLC) cells and an attractive target for enhancing the cytotoxicity of therapeutic agents, distinct roles isoforms NSCLC are largely unknown. In present study, we investigated AKT1 AKT2 using RNAi. The siRNA targeting or effectively decreased levels AKT2, respectively, A549 H460 cells. Cisplatin treatment these increased apoptotic death compared with control. siRNA-induced knockdown significantly basal...
Previous studies conducted cell expansion ex vivo using low initial plating densities for optimal and subsequent differentiation of mesenchymal stem cells (MSCs). However, MSC populations are heterogeneous culture conditions can affect the characteristics MSCs. In this study, differences in gene expression profiles adipose tissue (AT)-derived MSCs were examined after harvesting cultured at different densities. AT-MSCs from three donors plated a density 200 or 5,000 cells/cm2. After 7 days...
Abstract Background This study investigated the clinical significance of MYCN amplification within high‐risk neuroblastoma (NB). Methods Medical records 135 patients who were diagnosed with NB from 2004 to 2016 reviewed. Results Fifty‐one (38%) had amplified tumors, and remaining 84 (62%) nonamplified tumors. was associated abdominal primary site, less differentiated pathology, higher levels lactate dehydrogenase neuron‐specific enolase (NSE), lower vanillylmandelic acid level, larger tumor...
A nationwide survey was conducted to clarify the clinical features and outcomes of Korean children with Langerhans cell histiocytosis (LCH). Korea Histiocytosis Working Party analyzed data 603 patients who were diagnosed LCH between 1986 2010 from 28 institutions in Korea. Median age at diagnosis 65 months (range, 0 276 mo). Bone most frequently affected organ (79.6%) followed by skin (19.2%). Initially, 419 (69.5%) had single-system involvement (SS), 85 (14.1%) multisystem (MS) disease...
We aimed to investigate the impact of various genetic polymorphisms affecting thiopurine metabolism pathways and toxicity in paediatric acute lymphoblastic leukaemia patients for first time Korea.From May 2006 September 2016, 139 treated with combination chemotherapy including 6-mercaptopurine were included study. One hundred twenty-three variants 43 genes, TMPT NUDT15, screened using targeted genotyping, such as a MassARRAY system, direct sequencing polymerase chain reaction-restriction...
Abstract Background Single or tandem double high‐dose chemotherapy (HDCT) was used to treat children with newly diagnosed high‐risk relapsed medulloblastoma and supratentorial primitive neuroectodermal tumor (MB/sPNET) in order defer avoid radiotherapy young children. Procedure Thirty‐seven HDCTs were given 25 MB/sPNET. Tandem HDCT for 12 of 15 patients initially intended receive HDCT. Results Three‐year EFS (±SE) 6 (>3 years old), 8 (<3 11 MB/sPNET 83.3 ± 15.2%, 62.5 20.5%, 29.1...
Voriconazole is the drug of choice for invasive aspergillosis (IA) and levels are influenced by interactions with other drugs genetic predisposition. We performed a retrospective analysis voriconazole investigated adequacy in pediatric cancer patients hematopoietic cell transplant (HCT) recipients IA.Trough serum concentrations younger than 19 years during 30-month period were analyzed. The therapeutic range was determined as 1-6 µg/ml.A total 193 measurements at steady-state [86 on...
Epstein-Barr virus (EBV)-associated hemophagocytic lymphohistiocytosis (HLH), EBV-positive systemic T-cell lymphoproliferative disease (STLPD) of childhood, and chronic active EBV (CAEBV) infection may develop after primary infection. This study reviewed the clinicopathological spectrum EBV-associated T- natural killer (NK)-cell LPD, including STLPD CAEBV infection, with an analysis clonality.Clinicopathological features seven patients HLH or 12 were reviewed. Immunohistochemical staining a...
Pre-engraftment syndrome (PES) is poorly characterized, and its clinical significance the prognostic impact after unrelated cord blood transplantation (CBT) are unclear. To address these issues, we retrospectively analyzed incidence, risk factors, outcomes of PES in CBT recipients. Data 381 patients who received from 18 medical centers Korea were reviewed. was defined as unexplained fever >38.3°C not associated with infection, and/or skin rash or without evidence fluid retention before...