A5067090108- Head and Neck Cancer Studies
- Gastroesophageal reflux and treatments
- Dysphagia Assessment and Management
- Respiratory and Cough-Related Research
- RNA modifications and cancer
- Thyroid Cancer Diagnosis and Treatment
- Salivary Gland Tumors Diagnosis and Treatment
- Oral Health Pathology and Treatment
- Obstructive Sleep Apnea Research
- Eosinophilic Esophagitis
- Tracheal and airway disorders
- Oral and Maxillofacial Pathology
- Voice and Speech Disorders
- Cancer-related molecular mechanisms research
- Cancer-related gene regulation
- Allergic Rhinitis and Sensitization
- Asthma and respiratory diseases
- Head and Neck Anomalies
- Radiomics and Machine Learning in Medical Imaging
- Helicobacter pylori-related gastroenterology studies
- Otolaryngology and Infectious Diseases
- Epigenetics and DNA Methylation
- Thyroid and Parathyroid Surgery
- Esophageal Cancer Research and Treatment
- Neuroscience of respiration and sleep
Kyung Hee University Medical Center
2016-2025
Apollo Proton Cancer Centre
2025
Kyung Hee University
2015-2024
Kyung Hee University Hospital at Gangdong
2023-2024
Inha University
2024
Bridge University
2023-2024
Kangbuk Samsung Hospital
2009-2024
Sungkyunkwan University
2009-2024
Kyung Hee University Dental Hospital
2024
Harlem Hospital Center
2024
The objective of this work was to gather an international consensus group propose a global definition and diagnostic approach laryngopharyngeal reflux (LPR) guide primary care specialist physicians in the management LPR.
Abstract In this study we assessed the clinical significance of an epithelial-mesenchymal transition (EMT) gene signature and explored its association with tumor microenvironment related to immunotherapy in patients head neck squamous cell carcinoma (HNSCC). Genes were selected when mRNA levels positively or negatively correlated at least one well-known EMT marker. We developed consisting 82 genes. The classified into epithelial mesenchymal subgroups according signature. was validated three...
To determine salivary pepsin levels as a function of collection time.A prospective, case-control study.We selected 57 patients with clinical symptoms and signs laryngopharyngeal reflux who underwent 24-hour multichannel intraluminal impedance-pH (24h MII-pH) monitoring tests, 12 control subjects without reflux. All were instructed to collect saliva samples upon waking, 1 hour after each meal (3 times per day), any occurrence (LPR) symptoms. The in measured by using enzyme-linked...
Abstract Oral microbiota can alter cancer susceptibility and progression by modulating metabolism inflammation. We assessed the association between oral microbiome lymph node (LN) metastasis in squamous cell carcinoma (OSCC). collected a total of 54 saliva samples from patients with OSCC before surgery. LN was based on postoperative pathological examination. used QIIME2, linear discriminant analysis effect size (LEfSe), PICRUSt2 methods to analyze microbial dysbiosis. A random forest...
Abstract Background This study investigated the clinical significance of MYCN amplification within high‐risk neuroblastoma (NB). Methods Medical records 135 patients who were diagnosed with NB from 2004 to 2016 reviewed. Results Fifty‐one (38%) had amplified tumors, and remaining 84 (62%) nonamplified tumors. was associated abdominal primary site, less differentiated pathology, higher levels lactate dehydrogenase neuron‐specific enolase (NSE), lower vanillylmandelic acid level, larger tumor...
In general, benign neck cysts are treated by surgical excision. This can present technical difficulties and frequent recurrences, because of insufficient surgery. Sclerosing agents such as OK-432 have been tested for the nonsurgical treatment these cysts. We assessed efficacy sclerotherapy cysts.The study group consisted 75 patients (42 men, 33 women) diagnosed with between March 2001 December 2007 intralesional injection OK-432. The liquid content each cyst was aspirated much possible, same...
To compare the efficacy, relapse, and adverse effects between intralesional injection mouth rinse of triamcinolone acetonide (TA) in patients with oral lichen planus (OLP).A randomized controlled study.College medical center.Forty consecutive patients, who had been diagnosed OLP, were recruited. Participants randomly divided into 2 groups using or TA. The severity pain burning sensation on a 10-cm visual analog scale (VAS) Oral Health Impact Profile-14 (OHIP-14) assessed at weeks 0, 1, 2, 3,...
SOX2 copy number and mRNA expression were analysed to examine the clinical significance of activation in HNSCC. Gene signatures reflecting identified an HNSCC cohort. Patients with classified into two subgroups according gene signature: SOX2-high SOX2-low. The was further validated independent cohorts. Moreover, response radiotherapy assessed patients relationship between vitro experiment. subgroup had a better prognosis than SOX2-low all three patient Results multivariate regression...
To analyze laryngopharyngeal reflux (LPR) as an acidic, nonacidic, or mixed type according to 24-hour multi-channel intraluminal impedance (MII) pH monitoring and the clinical characteristics of each type.Ninety patients were prospectively enrolled in this study. All underwent MII a diagnostic tool. Eighty-three diagnosed with LPR. The classified into three groups hypopharyngeal probe: acid group, nonacid group. Subjective symptoms objective findings evaluated based on patients' responses...
Background Silastic splints have been used as effective tools for septal support, avoiding adhesion, and mucosal healing after surgery. Furthermore, although many surgeons insert splints, no well-designed trials exist to support their use. A randomized double-blinded controlled trial was performed. Methods We recruited 40 subjects who had undergone septoplasty only without sinus surgery or turbinoplasty. silastic splint inserted in one side of the nasal cavity at end each septoplasty, with...
Objective To analyze patterns of central lymph node (LN) metastasis to specific compartments in the neck and predictive factors contralateral paratracheal LN patients who underwent prophylactic bilateral dissection for papillary thyroid cancer (PTC). Study Design Prospective study. Setting Multitertiary centers. Subjects Methods One hundred forty consecutive total thyroidectomy unilateral PTC without evidence metastatic disease based on preoperative ultrasound imaging. The compartment was...
ABSTRACT Background The purpose of this study was to identify the prevalence sialoceles and risk factors associated with their formation after parotidectomy. Methods We performed a retrospective analysis data from consecutive patients who underwent partial superficial parotidectomy parotid tumors. Demographic data, preoperative imaging results, operative variables, including tumor type, incision size, method parenchymal disruption were assessed. Results Twenty‐three 357 (6.4%) undergoing...
// Young-Gyu Eun 1, 2 , Dongjin Lee 3 Young Chan Bo Hwa Sohn 1 Eui Hyun Kim 4 Sun Yim 5 Kee Hwan Kwon and Ju-Seog Department of Systems Biology, The University Texas MD Anderson Cancer Center, Houston, Texas, USA Otolaryngology-Head Neck Surgery, School Medicine, Kyung Hee University, Seoul, Republic Korea Hallym Neurosurgery, Severance Hospital, Brain Tumor Yonsei College Division Gastroenterology Hepatology, Internal Correspondence to: Lee, email: jlee@mdanderson.org Keywords: YAP1; gene...
Objectives/Hypothesis The aim of this study was to evaluate the clinicopathologic characteristics and pattern lymph node (LN) metastasis in papillary thyroid cancer (PTC) located isthmus. Study Design Retrospective cohort study. Methods One hundred ninety consecutive patients with PTC who underwent total thyroidectomy bilateral central neck dissection were analyzed. Preoperative ultrasonography reviewed identify Clinicopathologic factors including age, sex, tumor size, extrathyroidal...