A5073718739- Head and Neck Cancer Studies
- RNA modifications and cancer
- Advanced Radiotherapy Techniques
- Lung Cancer Diagnosis and Treatment
- Lung Cancer Research Studies
- Effects of Radiation Exposure
- Epigenetics and DNA Methylation
- Lung Cancer Treatments and Mutations
- Cancer, Hypoxia, and Metabolism
- Breast Cancer Treatment Studies
- Medical Imaging Techniques and Applications
- Colorectal and Anal Carcinomas
- Oral health in cancer treatment
- Digital Radiography and Breast Imaging
- Colorectal Cancer Surgical Treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer-related molecular mechanisms research
- Carbon Nanotubes in Composites
- Cancer-related gene regulation
- Gastric Cancer Management and Outcomes
- Cancer survivorship and care
- Nonmelanoma Skin Cancer Studies
- Radiation Therapy and Dosimetry
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Radiomics and Machine Learning in Medical Imaging
Kyung Hee University Medical Center
2016-2025
Kyung Hee University
2009-2024
Samsung Medical Center
2021
Alzheimer’s disease (AD) is the most common type of dementia. AD involves major pathologies such as amyloid-β (Aβ) plaques and neurofibrillary tangles in brain. During progression AD, microglia can be polarized from anti-inflammatory M2 to pro-inflammatory M1 phenotype. The activation triggering receptor expressed on myeloid cells 2 (TREM2) may result phenotype switching M2, which finally attenuated Aβ deposition memory loss AD. Low-dose ionizing radiation (LDIR) known ameliorate pathology...
SOX2 copy number and mRNA expression were analysed to examine the clinical significance of activation in HNSCC. Gene signatures reflecting identified an HNSCC cohort. Patients with classified into two subgroups according gene signature: SOX2-high SOX2-low. The was further validated independent cohorts. Moreover, response radiotherapy assessed patients relationship between vitro experiment. subgroup had a better prognosis than SOX2-low all three patient Results multivariate regression...
This study demonstrates rapid carbon nanotube (CNT) synthesis using a 150 kHz induction heating system, enabling precise temperature and pressure control in thermal chemical vapor deposition processes. CNT growth optimization at temperatures between 887 955 °C pressures from 1 to 700 Torr reveals that an optimized (887 °C) (100 Torr) yield enhanced field emission performance. The provided faster rates more consistent distribution across the substrate, significantly enhancing efficiency....
Abstract Casticin (CTC), one of the major components Vitex rotundifolia L., has been reported to exert significant beneficial pharmacological activities and can function as an antiprolactin, anticancer, anti‐inflammatory, neuroprotective, analgesic, immunomodulatory agent. This study aimed at investigating whether proapoptotic effects CTC may be mediated through abrogation signal transducers activators transcription‐3 (STAT3) signaling pathway in a variety human tumor cells. We found that...
Background Pancreatic cancer (PC), sometimes referred to as pancreatic ductal adenocarcinoma (PDAC), is a major cause of global mortality from cancer. very aggressive and devastating kind cancer, characterized by limited options for therapy low possibilities survival. Sulforaphane (SFN), naturally occurring sulfur-containing compound, believed possess anti-inflammatory, anti-obesity, anti-cancer characteristics. Objective However, efficient preventative treatment measures are essential SFN...
Background: The purpose of this study was to assess the effectiveness a recombinant human epidermal growth factor (EGF)-based cream for prevention acute radiation dermatitis in breast cancer patients receiving radiotherapy (RT). Materials and Methods: Between December 2012 April 2013, 40 who received postoperative RT were prospectively enrolled randomly assigned receive EGF-based (intervention group) or general supportive skin care (control group). grade pain score examined at weekly...
Gastric adenocarcinoma (GAC) is a lethal disease characterized by genomic and clinical heterogeneity. By integrating 8 previously established signatures for GAC subtypes, we identified 6 clinically molecularly distinct consensus subtypes (CGSs). CGS1 have the poorest prognosis, very high stem cell characteristics, IGF1 expression, but low alterations. CGS2 enriched with canonical epithelial gene expression. CGS3 CGS4 copy number alterations immune reactivity. However, differ in that has HER2...
Purpose. This study was performed to evaluate the efficacy and safety of Jaungo in preventing radiation dermatitis patients with breast cancer. Methods. Thirty were prospectively enrolled randomly assigned receive or general supportive skin care. Radiation pain examined at daily intervals from start radiotherapy until 4 weeks after its completion. The primary endpoint this incidence dermatitis. secondary endpoints time onset dermatitis, duration maximum score. Results. reduced grade ≥2...
The probability of recurrence cancer after adjuvant or definitive radiotherapy in patients with human papillomavirus-negative (HPV(-)) head and neck squamous cell carcinoma (HNSCC) varies for each patient. This study aimed to identify validate radiation sensitivity signature (RSS) HPV(-) HNSCC predict the radiotherapy.Clonogenic survival assays were performed assess radiosensitivity 14 lines. We identified genes closely correlated validated them Cancer Genome Atlas (TCGA) cohort. RSS...
Predictive factors for radiation pneumonitis (RP) after helical tomotherapy (HT) may differ from those linac-based radiotherapy. In this study, we identified predictive RP in patients with lung cancer treated HT.We retrospectively analyzed clinical, treatment-related and dosimetric 31 HT. was graded according to Common Terminology Criteria Adverse Events version 4.0 grade ≥2 defined as a event. We used Kaplan-Meier methods compute the actuarial incidence of RP. For univariate multivariate...
This study was performed to evaluate the efficacy and safety of clove-based herbal mouthwash in ameliorating radiation-induced oral mucositis patients with head neck cancer.Fourteen were prospectively enrolled this randomized either an experimental group or a control group. The swished their mouths during radiotherapy (RT), while clear water. primary end point incidence mucositis. secondary points time onset mucositis, duration supplemental nutrition through feeding tube, maximum pain score,...
Background: We propose a novel prognostic biomarker-based strategy for increasing the efficacy of radiotherapy (RT) in head and neck squamous cell carcinoma (HNSCC). Materials Methods: identified genes associated with superoxide dismutase 2 (SOD2) nuclear factor erythroid-2-related (NRF2) from gene-expression data The Cancer Genome Atlas (TCGA) by calculating Pearson correlation. Patients were divided into two groups using hierarchical clustering. Colony-formation assay was performed to...
Quality of life (QoL) has become a major concern as the survival time breast cancer increases. We investigated changes in QoL through comprehensive categorical analysis, for first three years after treatment including radiotherapy. A total 1156 patients were enrolled from 17 institutions. All survivors grouped according to surveillance period 9–15 months (first year), 21–27 (second and 33–39 (third year) end The 5-dimensional questionnaire by EuroQol group (EQ-5D) EORTC Life Questionnaire;...
Compared to conventional radiotherapy (RT), intensity-modulated (IMRT) significantly reduces the rate of treatment-induced late toxicities in head and neck cancer. However, a clear survival benefit IMRT over RT has not yet been shown. This study is among first comparative compare rates between helical tomotherapy cancer.From January 2008 November 2011, 37 patients received 30 for management We retrospectively compared treated with tomotherapy, analyzed prognostic factors survival.The 1-...
We describe patterns of tumor regression based on follow-up duration after radiotherapy (RT) or chemo-RT in patients with head and neck squamous cell carcinoma.Thirty-one carcinoma were included this study received definitive RT chemo-RT. The pattern primary treatment was evaluated every 1 to 2 months. Predictive factors for the length time full also analyzed.Among all patients, 27 showed tumor, 24 >50% regression, 15 total regression. gradually regressed during course follow-up. median 5.2...
Abstract Background Various cancer stem cell (CSC) biomarkers and the genes encoding them in head neck squamous carcinoma (HNSCC) have been identified evaluated. However, validity of these factors prognosis HNSCC has questioned remains unclear. In this study, we examined clinical significance CSC biomarker HNSCC, using five publicly available cohorts. Methods To predict patients with developed validated expression signatures whose mRNA levels correlated at least one four ( CD44 , MET ALDH1A1...
Although numerous studies have used systemic approaches to identify prognostic predictors in oral squamous cell carcinoma (OSCC), the effectiveness of these has not been assessed clinically. Further, mechanism underlying malignant behaviors OSCC is poorly characterized. This study aimed develop and verify accurate for patients assess associated biology. We identified an OSCC-recurrence-related gene signature (ORGS) using a Cox regression analysis. Functional enrichment analysis was enriched...
Background: There have not yet been any published studies on the effects of laughter therapy radiation-induced dermatitis in breast cancer patients treated with radiotherapy (RT). We assessed effectiveness preventing radiation cancer. Methods: Thirty-seven were prospectively enrolled this study. Eighteen assigned to experimental group and other 19 control group. The who received during RT. Laughter was started at onset RT provided twice a week until completion only without therapy. grade...
This study was designed to investigate the long-term oncologic outcomes for locally advanced rectal cancer patients after treatment with preoperative concurrent chemoradiotherapy followed by total mesorectal excision, and identify prognostic factors that affect survival pathologic response.From June 1996 2009, 135 were treated excision at Kyung Hee University Hospital. Patient data retrospectively collected analyzed in order determine survival.The median follow-up time 50 months (range, 4.5...
This study reports treatment outcomes after helical intensity-modulated radiotherapy (IMRT) in unresectable hepatocellular carcinoma (HCC) patients for whom transarterial chemoembolization (TACE) was considered ineffective or unsuitable.From January 2008 to December 2011, 22 HCC received IMRT. A daily dose of 1.8 4 Gy delivered at five fractions per week deliver a total 30 60 Gy. The most-prescribed fractionation 50 57.5 Gy, with 2.3 2.5 Gy.In the entire group, objective response rate...
We evaluated the effects of diabetes mellitus (DM) and DM-related serologic factors (HbA1c fasting glucose) on development radiation pneumonitis in patients with lung cancer.We retrospectively analyzed clinical data 123 cancer treated radiotherapy. Radiation was scored according to toxicity criteria Therapy Oncology Group. used binary logistic regression analysis find significant predictive for grade ≥3 pneumonitis.On univariable analysis, V20, mean dose, DM, HbA1c, glucose level were...
Background: We conducted this study to contribute resolving some controversial issues on management of nasopharyngeal carcinoma. Methods: Thirty-two patients with stage III-IVB carcinoma were included in retrospective study. All received concurrent chemoradiotherapy either 3D conformal radiotherapy or intensity-modulated radiotherapy. retrospectively analyzed the survival outcome, prognostic factors for survival, and toxicity outcome. Results: The 2- 5-year overall rates 89.9% 82.6%. distant...
We report the enhancement of carbon nanotube (CNT) field emitters by growing them directly on stripe-patterned alloy substrates. For a gate voltage 1300 V, CNT grown full and substrates achieved respective emission currents 0.22 2.32 mA, corresponding to tenfold performance enhancement. Performance is attributed reduced screening effect (as result spacing between strips) during damage-free patterning process. To verify ability generate X-rays, we designed assembled an electron gun through...