A5100748038- Traditional Chinese Medicine Studies
- Healthcare and Venom Research
- Food Quality and Safety Studies
- Medical Research and Treatments
- Acupuncture Treatment Research Studies
- Cytokine Signaling Pathways and Interactions
- Bone Tissue Engineering Materials
- Pharmacological Effects of Natural Compounds
- Agriculture, Soil, Plant Science
- Bioactive Compounds and Antitumor Agents
- Consumer Perception and Purchasing Behavior
- Complementary and Alternative Medicine Studies
- Ginseng Biological Effects and Applications
- PI3K/AKT/mTOR signaling in cancer
- Dermatology and Skin Diseases
- ZnO doping and properties
- Nutrition and Health in Aging
- Membrane-based Ion Separation Techniques
- Cardiovascular Function and Risk Factors
- Angiogenesis and VEGF in Cancer
- Medicinal Plant Pharmacodynamics Research
- Cardiac Imaging and Diagnostics
- Diverse Topics in Contemporary Research
- Anodic Oxide Films and Nanostructures
- Rheumatoid Arthritis Research and Therapies
University of Cambridge
2025
Dankook University
2020-2024
Kyung Hee University
2015-2024
Soonchunhyang University Hospital
2023-2024
Korea University Medical Center
2022-2024
Inha University
2003-2024
Kyung Hee University Medical Center
2012-2024
Kyung Hee University Hospital at Gangdong
2024
Hallym University Dongtan Sacred Heart Hospital
2024
Korea University
2014-2024
Epithelial-to-mesenchymal transition (EMT) is a critical cellular phenomenon regulating tumor metastases. In the present study, we investigated whether ginkgolic acid can affect EMT in lung cancer cells and related underlying mechanism(s) of its actions. We found that C15:1 (GA C15:1) inhibited cell proliferation, invasion, migration both A549 H1299 cells. GA also suppressed expression genes (Fibronectin, Vimentin, N-cadherin, MMP-9, MMP-2, Twist Snail) TGF-β-induced as assessed by reduced...
Brassinin (BSN), a potent phytoalexin found in cruciferous vegetables, has been to exhibit diverse anti-neoplastic effects on different cancers. However, the impact of BSN chronic myelogenous leukemia (CML) cells and possible mode its actions have not described earlier. We investigated anti-cytotoxic KBM5, KCL22, K562, LAMA84 CML underlying mechanisms action inducing programmed cell death. noted that could induce apoptosis, autophagy, paraptosis cells. induced PARP cleavage, subG1 peak...
Accumulating evidence suggests that Ginsenoside Rg3 appears to inhibit tumor growth including Lewis lung carcinoma, intestinal adenocarcinomas or B16 melanoma by inhibiting cell proliferation, invasion and metastasis. Endothelial progenitor cells (EPCs) appear play a key role in the of early tumors intervening with angiogenic switch promoting neovessel formation producing cytokines during progression. This paper reports novel mechanism Rg3, candidate anticancer bio-molecule, on angiogenesis...
Abstracts Benign prostate hyperplasia (BPH) is an age-related disease in men characterized by the growth of cells and hyperproliferation tissue. This condition closely related to chronic inflammation. In this study, we highlight therapeutic efficacy ellagic acid (EA) for BPH focusing on AR signaling axis STAT3. To investigate effect EA BPH, used EA, a phytochemical abundant fruits vegetables, treat testosterone propionate (TP)-induced rats RWPE-1 human epithelial cells. The treatment reduced...
It is generally known that hyperventilation produces an increase in neuronal excitability. However, the mechanism whereby a change CO2 partial pressure (Pco2) leads to changes neural excitability not known. We have studied this phenomenon rat hippocampal slices using double-barrelled microelectrodes for simultaneous recording of field excitatory postsynaptic potentials (EPSPs) and extracellular pH stratum radiatum area CAI. A drop Pco2 from control level, 36 mmHg 7 mmHg, produced 0.4–0.6...
Abstract Objective To compare the frequency of osteoporosis and bone mineral density ( BMD ) below expected range for age between female patients with rheumatoid arthritis RA healthy subjects to determine risk factors loss in . Method Two hundred ninety‐nine 246 age‐matched were included this study. lumbar spine, femoral neck total hip measured dual‐energy X ‐ray absorptiometry. A T ‐score −2.5 or lower postmenopausal women was defined as osteoporosis, a Z −2.0 females prior menopause age....
Abstract BACKGROUND Akt/mTOR/S6K1 signaling cascades play an important role both in the survival and proliferation of tumor cells. METHODS In present study, we investigated effects embelin (EB), identified primarily from Embelia ribes plant, on activation, associated gene products, cellular proliferation, apoptosis human prostate cancer RESULTS EB exerted significant cytotoxic suppressive Akt mTOR activation against androgen‐independent PC‐3 cells as compared to androgen‐dependent LNCaP...
Cinobufagin (CBG) is a cardiotoxic bufanolide steroid secreted by the skin and parotid venom glands of Asiatic toad Bufo bufo gargarizans (called Chan-Su). Although CBG known to exhibit anti-cancer activities, very little about its potential mechanism(s) action. In this study, we investigated whether mediates effect through modulation mitogen-activated protein kinases (MAPKs) signaling pathway in human multiple myeloma (MM) U266 cells. We found that caused significant activation ERK, JNK p38...
Brassinin (BSN), a type of indole compound derived from cruciferous vegetables, has shown anti‐cancer effects in cells and animals. Capsaicin (CAP), an alkaloid the chilli pepper, is also interest for its reported efficacy against various malignancies. The objective our study was to analyze potential synergistic anti‐tumor BSN combined with CAP on prostate cancer PC‐3 cells. After treatment at concentrations, cytotoxic effect analyzed by MTT method, proliferation, apoptosis, mitochondrial...
The advent of Industry 4.0 has significantly transformed the manufacturing sector, bringing advancements in quality control efficiency, environmental sustainability, and production development. These changes have led to development intelligent technologies such as artificial intelligence(AI). However, implementing AI solutions processes still faces challenges many aspects, particularly handling irregular datasets influenced by diverse settings. Especially field injection molding, inspection...
The advent of Industry 4.0 has significantly transformed the manufacturing sector, bringing advancements in quality control efficiency, environmental sustainability, and production development etc. These changes have led to intelligent technologies such as artificial intelligence(AI). However, implementing AI solutions processes still faces challenges many aspects, particularly handling irregular datasets influenced by diverse settings. Especially field injection molding, inspection often...
Abstract Background Promoting resistance to enteric pathogen infection is a core function of the gut microbiota; however, many specific host–commensal interactions that mediate this protection remain uncharacterised. To address knowledge gap, we monocolonised germ-free mice with mouse-derived commensal microbes screen for microbiota-induced Salmonella Typhimurium infection. Results We identified Enterocloster clostridioformis as protective species against S. E. selectively upregulates...