A5013437316- Venous Thromboembolism Diagnosis and Management
- Blood Coagulation and Thrombosis Mechanisms
- Complement system in diseases
- Platelet Disorders and Treatments
- Folate and B Vitamins Research
- Blood groups and transfusion
- Atrial Fibrillation Management and Outcomes
- Cancer-related molecular mechanisms research
- Hematopoietic Stem Cell Transplantation
- MicroRNA in disease regulation
- Estrogen and related hormone effects
- Diagnosis and Treatment of Venous Diseases
- Renal Diseases and Glomerulopathies
- Hemoglobinopathies and Related Disorders
- Angiogenesis and VEGF in Cancer
- Circular RNAs in diseases
- Central Venous Catheters and Hemodialysis
- Viral-associated cancers and disorders
- Sepsis Diagnosis and Treatment
- Cardiac tumors and thrombi
- Blood disorders and treatments
- Acute Myocardial Infarction Research
- Acute Lymphoblastic Leukemia research
- Colorectal Cancer Treatments and Studies
- Epigenetics and DNA Methylation
CHA University
2007-2018
CHA Bundang Medical Center
2013-2015
UiT The Arctic University of Norway
2014
University of Insubria
2009-2014
Centro Cardiologico Monzino
2014
Medical University of Vienna
2014
University of Vermont
2014
Federico II University Hospital
2014
Ca' Foncello Hospital
2014
Minnesota Department of Health
2014
Abstract MicroRNAs (miRNAs) are small, 18‐ to 22‐nucleotide non‐coding RNAs that regulate target gene expression. Although recent studies focused on various diseases harbor the miR‐146a C>G (rs2910164), 149 C>T (rs2292832), 196a2 (rs11614913), and 499 A>G (rs3746444) polymorphisms, role of miRNA genetic variants in colorectal cancer is still unknown. The present study aimed evaluate four polymorphisms patients with cancer. We enrolled 446 502 control subjects from Korean population....
In 2010, we proposed the first Korean Guidelines for Prevention of Venous Thromboembolism (VTE).It was applicable to patients, by modifying contents second edition Japanese guidelines prevention VTE and 8th American College Chest Physicians (ACCP) evidence-based clinical practice guidelines.From 2007 2011, conducted a nationwide study regarding incidence after major surgery using Health Insurance Review Assessment Service (HIRA) database.In addition, have considered 9th ACCP Evidenced-Based...
The metabolic syndrome (MS) is a known risk factor for arterial thromboembolism. Preliminary reports have also suggested the association between MS and venous thromboembolism (VTE).In this case-control study, we investigated VTE in Korean patients. Patients with objectively diagnosed healthy control subjects underwent clinical assessment presence of according to National Cholesterol Education Adult Treatment Panel III criteria modified body mass index (WHO Asian Pacific Perspective, 2000)....
Immunomodulatory properties of mesenchymal stem cells (MSCs) have been applied to reduce the incidence graft-versus-host disease (GVHD) after hematopoietic cell transplantation (HSCT). Among various sources MSCs that immunomodulatory effects in vitro, only placenta-derived (PD-MSCs) not evaluated an vivo model GVHD. In this study, we investigated PD-MSCs vitro and their clinical potential for controlling GVHD animal model.A was established by transplanting C57BL/6 donor bone marrow spleen...
Pre-engraftment syndrome (PES) is poorly characterized, and its clinical significance the prognostic impact after unrelated cord blood transplantation (CBT) are unclear. To address these issues, we retrospectively analyzed incidence, risk factors, outcomes of PES in CBT recipients. Data 381 patients who received from 18 medical centers Korea were reviewed. was defined as unexplained fever >38.3°C not associated with infection, and/or skin rash or without evidence fluid retention before...
Vascular endothelial growth factor (VEGF) and its receptor kinase insert domain-containing (KDR) play crucial roles in angiogenesis, which contributes to the development progression of solid tumors. The aim this study was investigate associations VEGF (-2578C > A, -1154G -634G C, 936C T) KDR (-604T C 1192G A) polymorphisms with colorectal cancer (CRC). A total 882 participants (390 CRC patients 492 controls) were enrolled study. genotyping performed by polymerase chain reaction-restriction...
Korean Guidelines for the Prevention of Venous ThromboembolismThis guideline focuses on primary prevention venous thromboembolism (VTE) in Korea.The guidelines should be individualized and aim at patients scheduled major surgery, as well with a history trauma, high-risk pregnancy, cancer, or other severe medical illnesses.Currently, no nation-wide data incidence VTE exist, randomized controlled trials aiming Korea have yielded few results.Therefore, these were based second edition Japanese...
Folate has essential roles in DNA synthesis, repair and methylation. metabolism-related gene variants may modulate the levels of this vitamin affect cancer risk. Thus, whether these polymorphisms play an important role carcinogenesis, particularly colorectal (CRC) development, been a subject interest. The present study investigated association between methylenetetrahydrofolate reductase (MTHFR), thymidylate synthase (TS) reduced folate carrier 1 (RFC1) genes CRC Polymorphisms MTHFR (677C>T...
MicroRNAs (miRNAs) are small 19- to 22-nucleotide sequences of RNA that participate in the regulation cell differentiation, cycle progression and apoptosis. Although single-nucleotide polymorphisms (SNPs) miRNA regions considered unlikely be functionally important, nucleotide variations within primary (pri)- or precursor (pre)-miRNAs may affect processing ultimately result modification expression. The aim this study was investigate associations between four SNPs pre-miRNA genes survival...