A5026435499- Multiple Myeloma Research and Treatments
- Acute Myeloid Leukemia Research
- Chemokine receptors and signaling
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Hematopoietic Stem Cell Transplantation
- Chronic Lymphocytic Leukemia Research
- Complement system in diseases
- Chronic Myeloid Leukemia Treatments
- Immune Cell Function and Interaction
- Platelet Disorders and Treatments
- Eosinophilic Disorders and Syndromes
- Hemoglobinopathies and Related Disorders
- Cancer Treatment and Pharmacology
- Renal Diseases and Glomerulopathies
- Hematological disorders and diagnostics
- Protein Degradation and Inhibitors
- CAR-T cell therapy research
- Blood groups and transfusion
- Mesenchymal stem cell research
- Immunotherapy and Immune Responses
- Acute Lymphoblastic Leukemia research
- Lymphoma Diagnosis and Treatment
- Cytokine Signaling Pathways and Interactions
- Kruppel-like factors research
- Immune Response and Inflammation
Chungnam National University Hospital
2015-2025
Chungnam National University
2016-2025
National University College
2018-2023
New Generation University College
2018-2023
Weatherford College
2020-2023
Daejeon University
2009-2022
Palmetto Hematology Oncology
2021
Versus Arthritis
2020
Princess Margaret Cancer Centre
2019
National University Cancer Institute, Singapore
2018
Stromal cell–derived factor-1 (SDF-1) provides a potent chemotactic stimulus for CD34+ hematopoietic cells. We cultured mobilized peripheral blood (PB) and umbilical cord (CB) up to 5 weeks examined the migratory activity of cobblestone area–forming cells (CAFCs) long-term culture–initiating (LTC-ICs) in transwell assay. In this system, SDF-1 or MS-5 marrow stromal placed lower chamber induced transmembrane transendothelial migration by 2- 5-week-old CAFCs LTC-ICs 3 hours. Transmigration was...
Abstract Background Post-transplantation cyclophosphamide (PTCy) and anti-thymocyte globulin (ATG) are common prophylactic strategies for graft-versus-host disease (GVHD) after haploidentical hematopoietic stem cell transplantation (haplo-HSCT). Interleukin (IL)-6 is a surrogate marker cytokine release syndrome (CRS) acute GVHD. Method The clinical outcomes complications of haplo-HSCT with PTCy plus ATG versus monotherapy were compared according to serum IL-6 levels at Chungnam National...
BackgroundThis study explored the impact of genetic polymorphisms in cytochrome P450 (CYP) enzymes and transporters on plasma trough concentration imatinib mesylate (IM) clinical response chronic myeloid leukemia (CML).Patients methodsIn total, 82 patients with CML who had been administered 400 mg IM daily for over 6 months were genotyped 11 single-nucleotide nine genes (CYP3A4, CYP3A5, CYP2C9, CYP2C19, CYP2D6, ABCB1, SLC22A1, SLC22A2 ABCG2) using blood samples. The responses assessed after...
Predictive Factors of Mortality in Population Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH): Results from a Korean PNH RegistryParoxysmal nocturnal hemoglobinuria (PNH) is progressive, systemic, life-threatening disease, characterized by chronic uncontrolled complement activation.A retrospective analysis 301 patients who had not received eculizumab was performed to systematically identify the clinical symptoms and signs predictive mortality.PNH hemolysis (lactate dehydrogenase...
Antithymocytic globulin (ATG) and post-transplant cyclophosphamide (PTCy) are frequently used regimens for graft-versus-host disease (GVHD) prophylaxis. However, there is lack of data about the difference regulatory T cell (Treg) subpopulation between these two regimens. We collected peripheral blood samples at day+21 after allogeneic hematopoietic stem transplantation (Allo-HSCT). analyzed Treg by flow-cytometer classified into 3 subgroups: naïve, effector non-suppressive Treg. And we...
Antithymocytic globulin (ATG) and post-transplant cyclophosphamide (PTCy) are frequently used regimens for graft-versus-host disease (GVHD) prophylaxis. However, there is a lack of data about the difference in regulatory T-cell (Treg) subpopulations between these two regimens. Peripheral blood samples were collected on day +21 following allogeneic hematopoietic stem cell transplantation (Allo-HSCT), Treg analyzed using flow cytometry. The populations categorized into three distinct...
Abstract The senescence of human mesenchymal stem cells (hMSCs) causes disruption tissue and organ maintenance, is thus an obstacle to cell-based therapies for disease. Although some researchers have studied changes in the characteristics hMSCs (decreases differentiation ability self-renewal), comparing young old ages, mechanisms cell not yet been defined. In this study, we developed a growth curve bone marrow derived MSCs (hBMSCs) which into hyperbolic state after passage number 7....
Background Transfusional iron overload and its consequences are challenges in chronically transfused patients with myelodysplastic syndromes ( MDSs ) or aplastic anemia AA ). Study Design Methods This was a prospective, multicenter, open‐label study to investigate the efficacy of deferasirox DFX by serial measurement serum ferritin S ‐ferritin) level, liver concentration LIC level using relaxation rates magnetic resonance imaging, other laboratory variables MDS . Results A total 96 showing...
Immune-checkpoint inhibitors have shown therapeutic efficacy in various malignant diseases. However, anti-programmed death (PD)-1 therapy has not clinical multiple myeloma.Bone marrow (BM) mononuclear cells were obtained from 77 newly diagnosed myeloma patients. We examined the expression of immune-checkpoint receptors BM CD8+ T and their functional restoration by ex vivo treatment with anti-PD-1 TGFβ inhibitors.We confirmed upregulation PD-1 PD-L1 cells, respectively, PD-1-expressing...
AMD3100, an antagonist of the CXCR4 chemokine receptor is soon to be used clinically for peripheral mobilization hematopoietic stem cells (HSCs) in patients with multiple myeloma. AMD3100 has been shown activate a G protein coupled and thus acts as partial agonist vitro. Thus, we explored whether affected survival proliferation myeloma vitro.The effects on two cell lines (RPMI8226 U266) well CD138+ obtained from several were analyzed by flow cytometry using annexin V colorimetric assay...
The present study retrospectively analyzed clinicopathological and clinical data from 43 adult patients with biphenotypic acute leukemia (BAL) 11 Korean institutes. incidence of BAL was 2.1% among leukemias. In terms immunophenotype, 31 had myeloid plus B-lymphoid (M + B), 10 T-lymphoid T), one B (B T). Patients M T phenotype significantly lower CR rate (55.6% vs. 88.0%, P = 0.039) overall survival (0% 33.9% at 5 years, 0.028) than those phenotype. Our results suggest that immunophenotype...
There has been no report on the clinical features or natural history of autoimmune hemolytic anemia (AIHA) in Korean adult population. This study retrospectively analyzed characteristics and long-term outcomes AIHA adults.Patients newly diagnosed with between January 1994 December 2010 at Chungnam National University Hospital were enrolled. Patient diagnosis, response to treatment, course disease documented.Thirty-two patients (31 females 1 male) a median age 48 years (range, 17-86) Of...
In T4a laryngeal cancer with thyroid cartilage invasion, no optimal frontline treatment has yet been defined in controlled trials.We reviewed data from 89 patients featuring invasion who were treated initially either total laryngectomy (n = 53) or a larynx-preservation strategy 36).The median progression-free survival (PFS) of the group had not attained at time analysis and was thus significantly longer than that (8.7 months). The overall (OS) underwent 87.2 months, (31.3 benefit primary...
Background/Aims Antiphospholipid antibodies (aPL) have been detected in various proportions of patients with primary immune thrombocytopenia (ITP), but the clinical significance this is debatable. The present study aimed to determine frequency and implications elevated aPL adult ITP. Methods We prospectively studied newly diagnosed ITP who were enrolled between January 2003 December 2008 at Chungnam National University Hospital. They evaluated for presence lupus anticoagulant (LA)...
The Korean Multiple Myeloma Working Party performed a nationwide registration of multiple myeloma patients via web-based data bank system.We retrospectively analyzed registered from 3,209 since 1999.The median overall survival (OS) was 50.13 months (95% confidence interval: 46.20-54.06 months). Patients < or =40 years demonstrated longer OS than >65 age (median 71.13 vs. 36.73 months, p 0.001). who received novel agents at any time during their treatments showed did not 42.23 55.50 Response...
of the Clinical Features Pernicious Anemia in a Korean PopulationTo determine approximate incidence and clinical features pernicious anemia population, we retrospectively analyzed data for patients with who were diagnosed between 1995 2010 at five hospitals Chungnam province.Ninety-seven enrolled, accounted 24% vitamin B12 deficiency anemia.The annual was 0.3 per 100,000.The median age 66 (range, 32-98) yr, male/female ratio 1.25.Anemia-associated discomfort most common symptom (79.4%),...
Background The C-X-C chemokine receptor 7 (CXCR7) has been shown to be a decoy for CXCR4 in certain cell types. We investigated the expression status and functional roles of CXCR7 acute myeloid leukemia (AML) cells vitro. Methods mRNA was knocked down AML by using small interfering RNA (siRNA) technology, subsequent biological alterations were evaluated Results All lines examined this study (U937, K562, KG1a, HL-60, MO7e) primary CD34+ obtained from patients with expressed at various levels....