A5071543805- Lymphoma Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Multiple Myeloma Research and Treatments
- CNS Lymphoma Diagnosis and Treatment
- Hemoglobinopathies and Related Disorders
- Viral-associated cancers and disorders
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Atrial Fibrillation Management and Outcomes
- Sirtuins and Resveratrol in Medicine
- Protein Degradation and Inhibitors
- Venous Thromboembolism Diagnosis and Management
- Nausea and vomiting management
- Cancer Treatment and Pharmacology
- Sarcoma Diagnosis and Treatment
- Peptidase Inhibition and Analysis
- Bone and Joint Diseases
- Breast Cancer Treatment Studies
- Calcium signaling and nucleotide metabolism
- T-cell and Retrovirus Studies
- Chronic Lymphocytic Leukemia Research
- Head and Neck Surgical Oncology
- Bone health and treatments
- Cancer-related cognitive impairment studies
- Inflammatory mediators and NSAID effects
- Hearing, Cochlea, Tinnitus, Genetics
Wonkwang University
2012-2022
Technical University of Munich
2019
Wonkwang University Medical Center
2010-2017
University of Ulsan
2005
Ulsan College
2005
Asan Medical Center
2005
Sirtuin1 (SIRT1) is a nicotinamide adenine dinucleotide-dependent deacetylase. Recently, it suggested that SIRT1 may be involved in the development of malignant tumors including mouse lymphoma. Therefore, we investigated prevalence and prognostic impact expression diffuse large B-cell lymphoma (DLBCL). Immunohistochemical SIRT1, p53, bcl2, CD10, bcl6, multiple myeloma-1 (MUM1) were evaluated by using 2 mm core from 104 DLBCL patients for tissue microarray. Positive was seen 74% (77/104)...
Peripheral T-cell lymphomas (PTCLs) are uncommon and their frequency is regionally heterogeneous. Several studies have been conducted to evaluate the clinical features treatment outcomes of this disease entity, but majority these were in limited areas, making it difficult comprehensively analyze relative features. Furthermore, no consensus for PTCLs has established. Therefore, we an Asia-specific study understand assess treatments Asian patients.We performed a multinational, multicenter,...
Abstract Background The breast is a rare extranodal site of non-Hodgkin lymphoma, and primary lymphoma (PBL) has been arbitrarily defined as disease localized to one or both breasts with without regional lymph nodes involvement. aim this study was evaluate the clinical outcomes in patients diffuse large B cell (DLBCL) involvement, find criteria PBL reflecting outcome prognosis. Methods We retrospectively analyzed data from 68 patients, newly diagnosed DLBCL involvement at 16 Korean...
Abstract The prognostic relevance of tumor human papillomavirus (HPV) status in anal squamous cell carcinoma (SCC) had not been previously investigated, although its to cervical, head and neck SCC is known. We retrospectively evaluated outcomes 47 patients with treated combined chemoradiotherapy (CCRT) determined HPV by DNA chip method p16 expression immunohistochemistry (IHC) from paraffin‐embedded tissues. median age was 65 years (range, 44–90 years). Sixteen (34%) were diagnosed T stage 3...
Primary breast diffuse large B-cell lymphoma (DLBCL) is an extremely rare presentation of non-Hodgkin's that has been associated with poorer clinical outcomes compared nodal DLBCL in the pre-rituximab era. The aim this study was to investigate impact rituximab on patients primary DLBCL. Data from 25 female receiving plus chemotherapy were matched 75 (1:3) by following five established prognostic factors (age, Ann Arbor stage, Eastern Cooperative Oncology Group performance status, serum...
Background Transfusional iron overload and its consequences are challenges in chronically transfused patients with myelodysplastic syndromes ( MDSs ) or aplastic anemia AA ). Study Design Methods This was a prospective, multicenter, open‐label study to investigate the efficacy of deferasirox DFX by serial measurement serum ferritin S ‐ferritin) level, liver concentration LIC level using relaxation rates magnetic resonance imaging, other laboratory variables MDS . Results A total 96 showing...
Abstract Background. In a previous pilot study, adrenal suppression was found to be common after antiemetic dexamethasone therapy in cancer patients. The objective of this large prospective multicenter study confirm the incidence and factors associated with secondary related patients receiving chemotherapy. Methods. Chemotherapy-naïve who were scheduled receive at least three cycles highly or moderately emetogenic chemotherapy as an enrolled. Patients suppressed response before those...
Data on the efficacy of olanzapine in patients receiving moderately emetogenic chemotherapy (MEC) are limited. This study aimed to evaluate and compare versus placebo controlling nausea vomiting MEC.We conducted a randomized, double-blind, placebo-controlled determine whether can reduce frequency chemotherapy-induced (CINV) improve quality life (QOL) palonosetron dexamethasone as prophylaxis for MEC-induced vomiting. The primary end point was complete response acute phase (0-24 hours after...
The Korean Multiple Myeloma Working Party performed a nationwide registration of multiple myeloma patients via web-based data bank system.We retrospectively analyzed registered from 3,209 since 1999.The median overall survival (OS) was 50.13 months (95% confidence interval: 46.20-54.06 months). Patients < or =40 years demonstrated longer OS than >65 age (median 71.13 vs. 36.73 months, p 0.001). who received novel agents at any time during their treatments showed did not 42.23 55.50 Response...
The neutrophil-to-lymphocyte ratio (NLR) is an independent prognostic marker in solid and hematological cancers. While the derived NLR (dNLR) was shown to be non-inferior large cohorts of patients with different cancer types, it has not been validated as a for multiple myeloma (MM) date.Between May 22, 2011 29, 2014, 176 MM from 38 centers who were ineligible autologous stem cell transplantation analyzed. dNLR calculated using complete blood count differential data. optimal cut-off value...
Abstract Interleukin‐3 (IL‐3) is produced under various pathological conditions and thought to be involved in the pathogenesis of inflammatory diseases; however, its function bone homeostasis normal or nature downstream molecular targets remains unknown. Here we examined effect IL‐3 on osteoclast differentiation from mouse human marrow‐derived macrophages (BMMs). Although can induce multiple myeloma marrow cells, greatly inhibited BMMs isolated healthy donors. These inhibitory effects were...
Standard treatment for locally advanced (stage III-IV) head and neck squamous cell cancer (LA-HNSCC) is concurrent chemoradiation therapy (CCRT) with cisplatin 100 mg/m2 every 3 weeks. For medically unfit patients susceptible to treatment-related adverse events, low-dose weekly (30–40 mg/m2) can be used as an alternative. In this study, we retrospectively compared the therapeutic outcomes of regimen standard in CCRT LA-HNSCC. The medical records histologically confirmed LA-HNSCC were...
Background: Peripheral T-cell lymphomas (PTCLs) are uncommon and their incidence is regionally heterogeneous. Several studies have been conducted to evaluate the clinical features treatment outcomes of this disease entity, but majority these were in limited areas, making it difficult comprehensively analyze relative features. Furthermore, no consensus for PTCLs has established. Therefore, we an Asia-specific study understand assess treatments Asian patients. Methods: We performed a...
Cancer-associated thrombosis is the second-leading cause of mortality in patients with cancer and presents a poor prognosis, lack effective treatment strategies. NAD(P)H quinone oxidoreductase 1 (NQO1) increases cellular nicotinamide adenine dinucleotide (NAD+) levels by accelerating oxidation NADH to NAD+, thus playing important roles homeostasis, energy metabolism, inflammatory responses. Using murine orthotopic 4T1 breast model, which multiple thrombi are generated lungs at late stage...
We investigated factors that influence outcomes in diffuse large B-cell lymphoma (DLBCL) patients treated with rituximab combined the CHOP regimen (R-CHOP) followed by upfront autologous stem cell transplantation (Auto-SCT).We retrospectively evaluated survival differences between subgroups based on age-adjusted International Prognostic Index (aaIPI) and revised-IPI (R-IPI) at diagnosis, disease status, positron emission tomographic/computerized tomographic (PET/CT) status 51 CD20-positive...
The treatment strategy for elderly patients older than 80 years with diffuse large B-cell lymphoma (DLBCL) has not been established because of poor tolerability and lack data.This multicenter retrospective study was conducted to investigate clinical characteristics, patterns outcomes who were diagnosed DLBCL at 19 institutions in Korea between 2005 2016.A total 194 identified (median age, 83.3 years). Of these, 114 had an age-adjusted International Prognostic Index (aaIPI) score 2-3 48 a...