A5086101664- Acute Myeloid Leukemia Research
- Pesticide Residue Analysis and Safety
- Lymphoma Diagnosis and Treatment
- Viral-associated cancers and disorders
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Treatments and Studies
- Hematopoietic Stem Cell Transplantation
- Retinoids in leukemia and cellular processes
- Mesenchymal stem cell research
- Multiple Myeloma Research and Treatments
- Central Venous Catheters and Hemodialysis
- COVID-19 Clinical Research Studies
- Technology and Data Analysis
- Consumer Perception and Purchasing Behavior
- Customer Service Quality and Loyalty
- Chronic Lymphocytic Leukemia Research
- Cancer therapeutics and mechanisms
- Platelet Disorders and Treatments
- Emotional Labor in Professions
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Neutropenia and Cancer Infections
- Chronic Myeloid Leukemia Treatments
- Agriculture, Soil, Plant Science
- Histone Deacetylase Inhibitors Research
- Medical Imaging and Pathology Studies
Soonchunhyang University
2009-2023
Bucheon University
2005-2023
Scripps Research Institute
2008-2021
Seoul Metropolitan Government
2009-2020
Yeungnam University Medical Center
2019-2020
Soonchunhyang University Hospital
2003-2019
Yeungnam University
1998-2018
Chungbuk National University
2015-2017
Kyungpook National University Hospital
2016
University of Rochester Medical Center
2008
Saliva is a body fluid with important functions in oral and general health. A consortium of three research groups catalogued the proteins human saliva collected as ductal secretions: 1166 identifications--914 parotid 917 submandibular/sublingual saliva--were made. The results showed that high proportion are found plasma and/or tears also present along unique components. identified involved numerous molecular processes ranging from structural to enzymatic/catalytic activities. As expected,...
PURPOSE. To define the role of serine protease HTRA1 in age-related macular degeneration (AMD) by examining its expression level and identifying potential substrates context primary RPE cell extracellular milieu. METHODS. Primary cultures were established from human donor eyes screened for CFH, ARMS2, risk genotypes using an allele-discrimination assay. genotyped cells was determined real-time PCR quantitative proteomics. Potential identified incubating RPE-conditioned medium with or without...
Amyloid beta (Aβ) peptides impair multiple cellular pathways and play a causative role in Alzheimer's disease (AD) pathology, but how the brain proteome is remodeled by this process unknown. To identify protein networks associated with AD-like we performed global quantitative proteomic analysis three mouse models at young old ages. Our revealed robust increase Apolipoprotein E (ApoE) levels nearly all regions increased Aβ levels. Taken together prior findings on ApoE driving accumulation,...
Cognitive decline (CD) is a major symptom of mild cognitive impairment (MCI). Patients with MCI have an increased likelihood developing Alzheimer’s disease (AD). Although cure for AD currently lacking, medication therapies and/or daily training in the early stage can alleviate progression and improve patients’ quality life. Accordingly, investigating CD-related biomarkers via brain imaging devices crucial diagnosis. In particular, “portable” enable frequent diagnostic checks as routine...
ObjectivesThe aim of this study was to elucidate patterns severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) clearance in the natural course asymptomatic disease 2019 (COVID-19).MethodsConsecutive patients with non-severe COVID-19 were included retrospectively. Asymptomatic a normal body temperature and no evidence pneumonia throughout assigned group. The reverse transcription PCR (RT-PCR) assay repeated every two five days after first follow-up RT-PCR assay. Negative conversion...
Proteome studies contribute markedly to our understanding of parasite biology, host-parasite interactions, and mechanisms drug action. For most antimalarial drugs neither mode action nor resistance development are fully elucidated although this would be important prerequisites for successfully developing urgently required novel antimalarials. Here, we establish a large-scale quantitative proteomic approach examine protein expression changes in trophozoite stages the malarial Plasmodium...
We experienced a case of primary renal synovial sarcoma in 32 year-old woman. On admission, she complained intermittent abdominal pain. radiologic examination, 12×10 cm-sized soft tissue mass was detected on the left kidney. The tumor had histologic and immunophenotypic features that were consistent with spindle cell type monophasic sarcoma. Four months after complete resection tumor, unilateral hematogenous metastasis developed lung. She treated combined chemotherapy doxorubicin ifosfamide...
While pleural effusion in multiple myeloma is relatively infrequent, myelomatous extremely rare. We experienced a 61-year-old woman with IgD-lambda and effusion. The diagnosis was made originally by biopsy, fluid cytology immunoelectropheresis of fluid. Transient improvement the observed after administration combination chemotherapy vincristine, melphalan, cyclophosphamide, prednisone (VMCP)/vincristine, adriamycin, (VCAP). Two months later, recurred no response to salvage therapy observed....
We developed a LC-MS/MS method for the determination of esculetin contents in medicinal plants. The analysis was performed using multiple reaction monitoring negative mode, and an XBridge™ C(18) column (2.1 × 100 mm, 3.5 µm) used. Methanol 0.1% formic acid were used gradient analysis. calibration curve showed good linearity (r(2) > 0.9993). limits detection quantitation 0.02 0.07 ng/mL, respectively. intra-day inter-day precisions 1.5-6.8 2.0-5.3%, respectively, accuracy 102.0-110.2%. 35...
본 연구는 2011년 서울 북부지역에서 유통되고 있는 농산물 2,914건을 대상으로 GC, HPLC, GC-MSD 및 LC-MSD을 이용한 다종농약다성분분석법에 따라 284종 대한 잔류농약 실태를 조사하였다. 중 431건에서 농약이 검출되어 14.8%의 검출률을 나타냈으며, 농약 검출빈도가 높은 농산물은 들깻잎 40.0%(28/70), 참나물 35.5%(11/31), 비름나물 30.0%(3/10), 시금치 27.7%(38/137) 순이었다. 이 농약잔류허용기준을 초과한 31건으로 부적합률은 1.0% 였으며 인삼 6건(19.4%), 들깻잎, 부추 각각 4건(12.9%), 파, 돌나물 3건(9.7%), 시금치, 상추 1건(3.2%)등이었다. 분석대상 중에서 검출된 성분은 59종으로 잔류허용기준을 농약은 21종이었다. 농약의 용도별 분포를 보면 살균제(56.4%)가 살충제(42.1%)에 비해 높았다. Procymidone의 가장 높았고 tolclofos-methyl,...
Purpose: To evaluate whether systemically injected bone marrow-derived mesenchymal stem cells (MSCs) can be incorporated into neuroretinal tissues and play an important role in retinal wound healing the laser-induced trauma model.Methods: Retinotomies were made by applying Nd:YAG laser to rat retina.On first day after injuries, cell suspensions that obtained from same line of (containing 1 × 10 6 green fluorescence protein [GFP]-marked MSCs) through a tail vein experimental group phosphate...
// Seong Hyun Jeong 1 , Yoo-Jin Kim 2 Je-Hwan Lee 3 Yeo-Kyeoung 4 Soo 5 Sung Kyu Park 6 Young Rok Do 7 Inho 8 Yeung-Chul Mun 9 Hoon Gu 10 Won Sik 11 Hyeon Gyu Yi 12 Young-Don Joo 13 Chul Choi 14 Suk Ran 15 Sang Min Na and Jun Ho Jang 16,* Department of Hematology-Oncology, Ajou University School Medicine, Suwon, South Korea Hematology, Seoul St. Mary’s Hospital, College The Catholic Korea, Seoul, Asan Medical Center, Chonnam National Hwasun Jeollanam-do, Division Internal Severance...
We performed a phase II trial to evaluate the efficacy and safety of modified fludarabine, cytarabine, attenuated-dose idarubicin (m-FLAI) regimen in elderly acute myeloid leukemia (AML) patients. Elderly (≥60 years) AML patients who had not previously received chemotherapy were enrolled study. Patients two consecutive cycles m-FLAI as an induction. The comprised fludarabine (25 mg/m(2) , days 1-4), cytarabine (1,000 (5 1-3). primary end point was complete remission (CR) rate. Secondary...
Abstract Introduction The role of inflammation in the pathophysiology polycythemia vera (PV) is important. presence JAK2 mutations important diagnosis PV, and serum levels erythropoietin (EPO) also play a supporting role. However, EPO show some limitations. neutrophil‐to‐lymphocyte ratio (NLR) platelet‐to‐lymphocyte (PLR) are readily available marker inflammation. Thus, we examined whether NLR & PLR might diagnose PV erythrocytosis patients. We compared diagnostic values. Methods...
SUMMARYObjective: To compare the efficacy of lenograstim and filgrastim on haematological recovery following an autologous peripheral blood stem cell transplantation (PBSCT) with high-dose chemotherapy.Methods: A retrospective case-controlled study.Results: Absolute neutrophil count (ANC) above 0.5 × 109 l−1 white (WBC) 4 for 3 consecutive days was achieved earlier than ((13.2 ± 8.0 vs 19.0 10.0 days, p = 0.004), (16.9 9.7 29.9 16.6 0.001), respectively). The platelet 20 x 109/l also (19.5...
We investigated factors that influence outcomes in diffuse large B-cell lymphoma (DLBCL) patients treated with rituximab combined the CHOP regimen (R-CHOP) followed by upfront autologous stem cell transplantation (Auto-SCT).We retrospectively evaluated survival differences between subgroups based on age-adjusted International Prognostic Index (aaIPI) and revised-IPI (R-IPI) at diagnosis, disease status, positron emission tomographic/computerized tomographic (PET/CT) status 51 CD20-positive...
PURPOSE: The purpose of this study was to investigate characteristics the effects a video strength exercise on grip strength, balance, timed up and go in frail elderly women. METHODS: Subjects were thirty people selected by screening tool they divided into group control group. carried out for three time week 12 weeks. Data analyzed with independent t-test between paired before after. RESULTS: There not significant differences However, there after one-leg stand eyes open improved decreases....
In using both hands, everyone dominantly use one hand and it is called left-handedness or right-handedness person. Measurements of grip pinch strength provide objective indexes to represent functional integrity the upper extremity. This study was conducted for thirty female college students(19 11 lefthandedness). For assessment type handedness, questionnaire used; strength, Jamar dynamometer gauge used. right dominant significantly higher than those non-dominant hand. addition, regular...