A5001212874- Entomopathogenic Microorganisms in Pest Control
- Insect Resistance and Genetics
- Mosquito-borne diseases and control
- Insect and Arachnid Ecology and Behavior
- Entomological Studies and Ecology
- Studies on Chitinases and Chitosanases
- Fungal Infections and Studies
- Insect Pest Control Strategies
- Antifungal resistance and susceptibility
- Virology and Viral Diseases
- Enzyme Production and Characterization
- Nematode management and characterization studies
- Sperm and Testicular Function
- Insect symbiosis and bacterial influences
- Allergic Rhinitis and Sensitization
- Viral Infections and Vectors
- Insect and Pesticide Research
- Venomous Animal Envenomation and Studies
- Protein Hydrolysis and Bioactive Peptides
- SARS-CoV-2 and COVID-19 Research
- Healthcare and Venom Research
- Long-Term Effects of COVID-19
- Enzyme Catalysis and Immobilization
- Insect Utilization and Effects
- Hormonal and reproductive studies
Universidade Federal do Rio Grande do Sul
2015-2025
Hospital de Clínicas de Porto Alegre
2017-2024
Scripps Research Institute
2013-2018
Univates
2017
University of Buenos Aires
2004
University of Pavia
1997-1998
Centro di Riferimento Oncologico
1986
Alleanza Contro il Cancro
1981
Cryptococcus neoformans, a pathogenic yeast, causes meningoencephalitis, especially in immunocompromised patients, leading some cases to death. Microbes biofilms can cause persistent infections, which are harder treat. Cryptococcal becoming common due the growing use of brain valves and other medical devices. Using shotgun proteomics we determine differences protein abundance between biofilm planktonic cells. Applying bioinformatic tools, also evaluated metabolic pathways involved...
Conidial contact with an arthropod surface is the first step of fungal penetration and infection process. However, conidia Metarhizium anisopliae have associated components, like enzymes that could be involved in triggering process toxic effects not yet been well characterized. Fungi produce many also are components found bacteria animal venoms thus may considered as potential virulence factors. In this work, we report several enzymatic activities from spore protein extracts. The major...
The mangroves are among the most productive and biologically important environments. possible presence of cellulolytic enzymes microorganisms useful for biomass degradation as well taxonomic functional aspects two Brazilian were evaluated using cultivation metagenomic approaches. From a total 296 with visual differences in colony morphology growth (including bacteria, yeast filamentous fungus), 179 (60.5%) 117 (39.5%) isolated from Rio de Janeiro (RJ) Bahia (BA) samples, respectively. RJ...
Metarhizium anisopliae is an entomopathogenic fungus used in the biological control of some agricultural insect pests, and efforts are underway to use this insect-borne human diseases. A large repertoire proteins must be secreted by M. cope with various available nutrients as switches through different lifestyles, i.e., from a saprophytic, infectious, plant endophytic stage. To further evaluate predicted secretome anisopliae, we employed genomic transcriptomic analyses, coupled phylogenomic...
Global campaign against COVID-19 have vaccinated a significant portion of the world population in recent years. Combating pandemic with mRNA vaccines played pivotal role global immunization effort. However, individual responses to vaccine are diverse and lead varying vaccination efficacy. Despite progress, complete understanding molecular mechanisms driving immune response remains elusive. To address this gap, we combined novel nanoparticle-based proteomic workflow tandem mass tag (TMT)...
Abstract The Zika Virus (ZIKV) is a Flavivirus that caused recent outbreak worldwide resulting in different neurological outcomes are still poorly characterized and understood. Concerning this issue, vitro vivo models being applied to improve the molecular understanding of ZIKV infection. In work, applying shotgun proteomics we revealed differential infection proteome Vero cells, non-neural cell model. A dramatic change from was found including expression several proteins previously...
Metarhizium anisopliae is an entomopathogenic fungus that has evolved specialized strategies to infect insect hosts. Here we analyzed secreted proteins related Dysdercus peruvianus infection. Using shotgun proteomics, abundance changes in 71 were identified after exposure host cuticle. Among these classical fungal effectors by pathogens degrade physical barriers and alter physiology. These include lipolytic enzymes, Pr1A, B, C, I, J proteases, ROS-related proteins, oxidorreductases,...
Abstract Zika virus (ZIKV) infection during pregnancy was associated with microcephaly in neonates, but clinical and experimental evidence indicate that ZIKV also causes neurological complications adults. However, the changes neuron-glial communication, which is essential for brain homeostasis, are still unknown. Here, we report hippocampal slices from adult rats exposed acutely to showed significant cellular alterations regarding redox inflammatory process, neurotrophic functions molecular...