A5040701010- Neuroinflammation and Neurodegeneration Mechanisms
- Tryptophan and brain disorders
- Neuroscience and Neuropharmacology Research
- Sirtuins and Resveratrol in Medicine
- S100 Proteins and Annexins
- Alzheimer's disease research and treatments
- Neurogenesis and neuroplasticity mechanisms
- Biochemical effects in animals
- Heme Oxygenase-1 and Carbon Monoxide
- Long-Term Effects of COVID-19
- RNA regulation and disease
- Mitochondrial Function and Pathology
- Sulfur Compounds in Biology
- Alcoholism and Thiamine Deficiency
- Biochemical Acid Research Studies
- Folate and B Vitamins Research
- Mosquito-borne diseases and control
- Genomics, phytochemicals, and oxidative stress
- Infectious Encephalopathies and Encephalitis
- Adenosine and Purinergic Signaling
- Connexins and lens biology
- Advanced Glycation End Products research
- Metabolism and Genetic Disorders
- Immune Response and Inflammation
- Adipose Tissue and Metabolism
Universidade Federal do Rio Grande do Sul
2016-2025
Universidade Federal do Rio Grande
2021-2024
Resveratrol, a polyphenol presents in grapes and wine, displays antioxidant anti-inflammatory properties cytoprotective effect brain pathologies associated to oxidative stress neurodegeneration. In previous work, we demonstrated that resveratrol exerts neuroglial modulation, improving glial functions, mainly related glutamate metabolism. Astrocytes are major class of cells regulate neurotransmitter systems, synaptic processing, energy metabolism defense against stress. This study sought...
Neuroinflammation is a common feature during the development of neurological disorders and neurodegenerative diseases, where glial cells, such as microglia astrocytes, play key roles in activation maintenance inflammatory responses central nervous system. now known to involve neurometabolic shift, addition an increase energy consumption. We used two approaches (in vivo ex vivo) evaluate effects lipopolysaccharide (LPS)-induced neuroinflammation on reprogramming, modulation glycolytic pathway...
Glutamate is the major excitatory neurotransmitter in brain and over-stimulation of glutamate receptors, NMDA, AMPA kainate (KA), may cause neuronal death epilepsy, seizures neurodegenerative diseases. Mitochondria have critical cellular functions that influence excitability, such as regulation Ca(2+) homeostasis ATP production to maintain Na(+)K(+)-ATPase central nervous system (CNS). However, mitochondria are also primary site reactive oxygen species (ROS) production, oxidative stress can...
Ammonia is implicated as a neurotoxin in brain metabolic disorders associated with hyperammonemia. Acute ammonia toxicity can be mediated by an excitotoxic mechanism, oxidative stress and nitric oxide (NO) production. Astrocytes interact neurons, providing support protecting against excitotoxicity. also convert excess glutamate into glutamine via synthetase (GS). Resveratrol, polyphenol found grapes red wines, exhibits antioxidant anti-inflammatory properties modulates glial functions, such...
Physical exercise effects on brain health and cognitive performance have been described. Synaptic remodeling in hippocampus induced by physical has described animal models, but the underlying mechanisms remain poorly understood. Changes astrocytes, glial cells involved synaptic remodeling, need more characterization. We investigated effect of moderate treadmill (20 min/day) for 4 weeks some parameters astrocytic activity rat hippocampal slices, namely, fibrillary acidic protein (GFAP),...
Abstract Guanosine, a guanine‐based purine, is an extracellular signaling molecule that released from astrocytes and shows neuroprotective effects in several vivo vitro studies. Our group recently showed guanosine presents antioxidant properties C6 astroglial cells. The heme oxygenase 1 pathway associated with protection against oxidative stress. Azide, inhibitor of the respiratory chain, frequently used experimental models to induce nitrosative Thus, goal this study was investigate effect...
Abstract Alpha lipoic acid (LA) is a sulfhydryl compound, used as dietary supplement and to treat variety of conditions associated oxidative stress. Glial cells are key modulators neuroprotection. We show here that LA modulates specific glial parameters in C6 astrocyte cell line, such glutamate uptake, glutamine synthetase (GS) activity glutathione content, commonly with the protective role cells. (10 50 μM) after 24 h treatment significantly decreased formation reactive oxygen species (ROS)...