A5065828298- Alzheimer's disease research and treatments
- Diet and metabolism studies
- Sirtuins and Resveratrol in Medicine
- Thyroid Disorders and Treatments
- Vector-Borne Animal Diseases
- Barrier Structure and Function Studies
- Heme Oxygenase-1 and Carbon Monoxide
- Advanced Neuroimaging Techniques and Applications
- Nitric Oxide and Endothelin Effects
- Tryptophan and brain disorders
- Animal Disease Management and Epidemiology
- Adipose Tissue and Metabolism
- Dietary Effects on Health
- Neuroscience and Neuropharmacology Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Mitochondrial Function and Pathology
- T-cell and Retrovirus Studies
Universidade Federal do Rio Grande do Sul
2024-2025
Caloric restriction (CR) has been proposed as a nutritional strategy to combat chronic diseases, including neurodegenerative well delay aging. However, despite the benefits of CR, questions remain about its underlying mechanisms and cellular molecular targets.
<title>Abstract</title> Thyroid hormone is the regulator of brain cell maintenance, plasticity and energy production. The activation process T4 into T3 depends on type 1 2 deiodinases, 3 (D3) inactivates T3. Several mechanisms, as oxidative stress, led by disease, imbalances D3 function. response in adult tissue context different diseases not defined. We evaluated induction its effects two animal models. Methodology: To metabolic-dysfunction associated steatotic liver disease (MASLD) model,...
Background In the sporadic model of Alzheimer's disease (AD), induced by intracerebroventricular streptozotocin (STZ) administration, cognitive impairment is accompanied specific astrocytic changes in hippocampus prior to amyloid deposition. Objective Hypothesizing that synthesis GABA, via MAO-B, contributes ammonia elevation, thereby compromising antioxidant defense and ATP synthesis, possibly contributing damage, we determined hippocampal levels glutamine synthetase (GS), monoamine oxidase...