A5076225032- Medicinal Plant Extracts Effects
- Neuroscience and Neuropharmacology Research
- Parkinson's Disease Mechanisms and Treatments
- Tryptophan and brain disorders
- Organoselenium and organotellurium chemistry
- Neurotransmitter Receptor Influence on Behavior
- Olfactory and Sensory Function Studies
- Phytochemicals and Antioxidant Activities
- Medicinal Plants and Neuroprotection
- Neuroinflammation and Neurodegeneration Mechanisms
- Cholinesterase and Neurodegenerative Diseases
- Nerve injury and regeneration
- Sirtuins and Resveratrol in Medicine
- Natural Antidiabetic Agents Studies
- Neurobiology and Insect Physiology Research
- Phytochemistry Medicinal Plant Applications
- Biochemical Analysis and Sensing Techniques
- Phytochemistry and Biological Activities
- Botulinum Toxin and Related Neurological Disorders
- Essential Oils and Antimicrobial Activity
- Pesticide Exposure and Toxicity
- Natural Compound Pharmacology Studies
- Heavy Metals in Plants
- Selenium in Biological Systems
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
Universidade Federal de Santa Maria
2015-2025
Departamento de Ciência e Tecnologia
2017
Universidade Federal do Rio Grande do Sul
2016
Universidade Federal do Pampa
2013
Instituto Biológico
2012
Universidade do Vale do Paraíba
2010
The pathology of a gastric ulcer is complex and multifactorial. Gastric ulcers affect many people around the world its development result imbalance between aggressive protective factors in mucosa. In this study, we evaluated ethanolic extract Rosmarinus officinalis L. (eeRo); plant, more commonly known as rosemary, has attracted interest scientific community due to numerous pharmacological properties their potential therapeutic applications. Here, tested preventive effects eeRo against...
Silymarin is a standardized extract from the dried seeds of milk thistle ( Silybum marianum L. Gaertn.) clinically used as an antihepatotoxic agent. The aim this study was to investigate antibacterial and antifungal activity silymarin its major constituent (silibinin) against different microbial strains their modulatory effect on drugs utilized in clinical practice. demonstrated antimicrobial little significance bacterial tested, with MIC (minimum inhibitory concentration) values 512 µ g/mL....
The production of reactive species over physiological levels associated to pathogenic bacteria could represent a high risk for many diseases. Rosmarinus officinalis L. is used around the world due its pharmacological proprieties. So, in this study our aim test first time if R. extract (eeRo) and fractions (DCM, EA, ButOH) have better or similar antioxidant action standars among themselves vitro ex vivo, brain, stomach liver rats. Moreover, we intend clarify their possible effects on...
In this study, we investigated the possible antidepressant-like effect of I. paraguariensis in rats. Rats were treated for four weeks with an aqueous extract drinking water, following traditional preparation beverage. After period treatment, behavioral (elevated plus-maze, open field test, and forced swimming test) biochemical parameters (lipid peroxidation assay, thiol content, vitamin C levels, monoamine oxidase activity) evaluated. Animals also analyzed on test after 24 hours intake. An...
Spermidine (SPD) is an endogenous polyamine that modulates N-methyl-D-aspartate (NMDA) receptor function, and has been reported to facilitate memory formation. In the current study we determined whether or not PKA/CREB signaling pathway involved in SPD-induced facilitation of inhibitory avoidance task adult rats. The post-training administration cAMP-dependent protein kinase (PKA) inhibitor, N-[2-bromocinnamylamino)ethyl]-5-isoquinoline sulfonamide [H-89, 0.5 ρmol intrahippocampal (ih)]...
Thimerosal (THIM) is a well-established antifungal and antiseptic agent widely used as preservative in vaccines. Recent studies identified the neurotoxic effects of THIM, including malfunction monoaminergic system. However, underlying cytotoxic mechanisms are not well understood. Here we fruit fly Drosophila melanogaster to investigate THIM-induced neurotoxicity. We focused on dopaminergic system, rate-limiting enzyme tyrosine hydroxylase (DmTyrH), test hypothesis that THIM can impair...
Reserpine treatment is a putative animal model of orofacial dyskinesia, tremor, and Parkinsonism. Here, we examined the effects resveratrol, polyphenol with neuroprotective properties primarily contained in red grapes wine, an vacuous chewing movements (VCMs) induced by reserpine. Mice were treated reserpine (1 mg/kg, subcutaneously on days 1 3) and/or resveratrol (5 intraperitoneally 3 consecutive days). VCM, locomotor, exploratory performance evaluated. produced increase VCM intensity,...
Neuropathic pain is a debilitating condition that often resistant to common analgesics, such as opioids, but sensitive some antidepressants, an effect seems be mediated by spinal cord 5-HT3 receptors. Because the analgesic potential of monoamine oxidase-A (MAO-A) inhibitors understudied, we evaluated antinociceptive reversible MAO-A moclobemide and 2-(3,4-dimethoxy-phenyl)-4,5-dihydro-1H-imidazole (2-DMPI) in mouse neuropathic model induced chronic constriction injury (CCI) sciatic nerve....