A5001083119- Bacterial biofilms and quorum sensing
- Antimicrobial agents and applications
- Mycobacterium research and diagnosis
- Phenothiazines and Benzothiazines Synthesis and Activities
- Microtubule and mitosis dynamics
- Selenium in Biological Systems
- Tuberculosis Research and Epidemiology
- Antimicrobial Peptides and Activities
- Antibiotic Resistance in Bacteria
- Infectious Diseases and Mycology
- Healthcare Regulation
- Genetics, Aging, and Longevity in Model Organisms
- Cellular transport and secretion
- Nuclear Structure and Function
- Cancer, Hypoxia, and Metabolism
- Organoselenium and organotellurium chemistry
- Mitochondrial Function and Pathology
- Essential Oils and Antimicrobial Activity
- Healthcare during COVID-19 Pandemic
- Linguistics and Language Studies
- Enterobacteriaceae and Cronobacter Research
- Quinazolinone synthesis and applications
- Methemoglobinemia and Tumor Lysis Syndrome
- Chronic Lymphocytic Leukemia Research
- Cholinesterase and Neurodegenerative Diseases
University of Münster
2022-2025
Universidade Federal de Santa Maria
2013-2021
Universitario Francisco de Asís
2019
The production of reactive species over physiological levels associated to pathogenic bacteria could represent a high risk for many diseases. Rosmarinus officinalis L. is used around the world due its pharmacological proprieties. So, in this study our aim test first time if R. extract (eeRo) and fractions (DCM, EA, ButOH) have better or similar antioxidant action standars among themselves vitro ex vivo, brain, stomach liver rats. Moreover, we intend clarify their possible effects on...
Abstract Metastatic cancer cells undergo metabolic reprogramming, which involves changes in the fluxes, including endocytosis, nucleocytoplasmic transport, and mitochondrial metabolism, to satisfy their massive demands for energy, cell division, proliferation compared normal cells. We have previously demonstrated ability of two different types compounds interfere with linchpins Pitstop-2 1,6-hexanediol (1,6-HD). 1,6-HD disrupts glycolysis enzymes function, enhancing reactive oxygen species...
Organic selenium compounds possess numerous biological properties, including antioxidant activity. Yet, the high toxicity of some them, such as diphenyl diselenide (DPDS), is a limiting factor in their current usage. Accordingly, we tested four novel organic non-parasite nematode Caenorhabditis elegans and compared efficacy to DPDS. The are β-selenoamines (1-phenyl-3-(p-tolylselanyl)propan-2-amine (C1) 1-(2-methoxyphenylselanyl)-3-phenylpropan-2-amine (C2) analogs DPDS (1,2-bis...
Improving overall health and quality of life, preventing diseases increasing life expectancy are key concerns in the field public health. The search for antioxidants that can inhibit oxidative damage cells has received a lot attention. Rosmarinus officinalis L. represents an exceptionally rich source bioactive compounds with pharmacological properties. In present study, we explored effects ethanolic extract R. (eeRo) on stress resistance longevity using non-parasitic nematode Caenorhabditis...
Clathrin-mediated endocytosis (CME) is an essential cell physiological process of broad biomedical relevance. Since the recent introduction Pitstop-2 as a potent CME inhibitor, we and others have reported on substantial clathrin-independent inhibitory effects. Herein, developed experimentally validated novel fluorescent derivative Pitstop-2, termed RVD-127, to clarify diverse Using were able trace additional protein targets Pitstop-2. Besides inhibiting CME, RVD-127 proved directly...
Background: Escherichia coli has an adaptive metabolism and many strains are resistant to classical antibacterial agents, due this resistance, it can cause severe clinical infections. In addition, few novel agents have been developed in recent years, which corroborate with antimicrobial resistance. For reason, innovative antimicrobials targets modes of action needed. Keywords: Antibacterial properties, biofilm formation, metal-coordinated SMZ, respiratory activity, sulfamethoxazole.
Microbial infections caused by sessile microorganisms are known to be a more challenging issue than the same in planktonic state. Pseudomonas aeruginosa is an opportunistic pathogen and biofilm-forming agent. This species presents intense cellular communication mediated signaling molecules. process as quorum sensing (QS) induces transcription of specific genes that favors cell density growth three-dimensional bacterial grouping. In this context, discovery compounds capable inhibiting action...
The present study aimed to genotypically and phenotypically characterize clinical isolates of carbapenem-resistant Enterobacteriaceae collected from inpatients at the University Hospital Santa Maria, during seven months. Among subjected modified Hodge test (MHT), 62.5% were positive, indicating possible production carbapenemase. Polymerase chain reaction (PCR) demonstrated that blaKPC was most frequently found gene (31%), followed by blaIMP (12.5%). Combined use methods is needed identify...
This study evaluated the prevalence of nontuberculous mycobacterium (NTM) in relation to total number cases mycobacterial infections detected patients admitted at University Hospital Santa Maria from 2008 2010. From positive samples for genus Mycobacterium, 67% belonged Mycobacterium tuberculosis complex (MTBC) and 33% them were classified as NTM. investigation aims contribute epidemiology mycobacterioses, inasmuch infected by NTM require distinctive treatment monitoring comparison with those MTBC.
Lung cancer is the leading cause of deaths. Nonsmall cell lung (NSCLC) accounts for vast majority histological subtypes and at advanced stage exhibits extremely low survival rate. Certain compounds, such as glycols, inhibit migration decreased viability highly metastatic NSCLC cells A549_3R has been recently shown. The glycols‐induced effects are associated with a parallel reduction ATP production, detected in spheroids embedded 3D desmoplastic‐like extracellular matrix, following overnight...
The use of drugs in fixed-dose combination (FDC) is now recommended by the World Health Organization (WHO) due to emergence multidrug-resistant strains Mycobacterium tuberculosis. FDC uses different against tuberculosis (TB) a single tablet for phase-intensive therapeutic intervention. This therapy aims optimize treatment, prevent inappropriate drugs, and new resistant strains. study evaluate susceptibility clinical isolates M. rifampicin, isoniazid, ethambutol, pyrazinamide. antimicrobials...
Abstract The small compound Pitstop‐2 is a recent potent inhibitor of clathrin‐mediated endocytosis (CME), widely used in biomedical research areas. In years, however, it observed that exhibits CME‐independent inhibitory effects on nuclear pore complexes (NPCs), the nucleocytoplasmic gatekeepers. NPCs are elaborate proteinaceous transport nano‐machineries crucial physiological importance rendering them novel targets for various medical applications. They mediate all forming physiologically...