A5000148373- Phytochemistry Medicinal Plant Applications
- Tryptophan and brain disorders
- Medicinal Plants and Neuroprotection
- Natural product bioactivities and synthesis
- Phytochemicals and Antioxidant Activities
- Agricultural and Food Sciences
- Genomics, phytochemicals, and oxidative stress
- Curcumin's Biomedical Applications
- Antioxidant Activity and Oxidative Stress
- Neuroinflammation and Neurodegeneration Mechanisms
- Graphene and Nanomaterials Applications
- Inflammasome and immune disorders
- Nanoparticles: synthesis and applications
- Essential Oils and Antimicrobial Activity
- Natural Antidiabetic Agents Studies
- Mesenchymal stem cell research
- Coffee research and impacts
- Cholinesterase and Neurodegenerative Diseases
- Plant biochemistry and biosynthesis
- Aluminum toxicity and tolerance in plants and animals
- Antimicrobial agents and applications
- Nanoparticle-Based Drug Delivery
- Antioxidants, Aging, Portulaca oleracea
- Ginkgo biloba and Cashew Applications
- Advanced Nanomaterials in Catalysis
Universidade Franciscana
2017-2025
University of Toronto
2016-2024
Franciscan University of Steubenville
2019-2022
Universidade Federal de Santa Maria
2010-2018
Universidade Federal do Paraná
2017
Universidade Luterana do Brasil
2017
Universidade Federal de Santa Catarina
2017
Morpho (United States)
2016
Biogen (Switzerland)
2014
Universidade do Vale do Paraíba
2007
Neuropsychiatric diseases, such as bipolar disorder (BD) and schizophrenia (SCZ), have a very complex pathophysiology. Several current studies describe an association between psychiatric illness mitochondrial dysfunction consequent cellular modifications, including lipid, protein, DNA damage, caused by oxidative stress. Euterpe oleracea (açaí) is powerful antioxidant fruit. Açaí Amazonian palm fruit primarily found in the lowlands of rainforest, particularly floodplains Amazon River. Given...
COVID-19 has been the biggest public health problem worldwide. Several people were infected by SARS-CoV-2 virus, developing or not related symptoms. Among symptoms, many subjects had fever, cough, muscle pain, headache, loss of taste, smell, among others, while some individuals presented more complex such as severe acute respiratory syndrome. Still today there is no specific treatment against COVID-19. Although pharmacological protocols tried, including for example antibiotics and...
Inflammasome activation plays a critical role in lung inflammation, with the NLRP3 (NOD, LRR and pyrin domain-containing protein 3) inflammasome serving as key mediator of inflammatory cytokine release pyroptotic cell death. This study investigates effects bioactive flavonoid extract (BFE), potential modulator NLRP3-mediated inflammation using THP-1 derived macrophages, A549 cells (2D cells), organoids (3D cells). Cells were primed lipopolysaccharide (LPS), treated BFE, then activated...
Bipolar disorder (BD) is increasingly recognized as a with both mitochondrial dysfunction and heightened inflammatory reactivity, yet their contribution to neuronal activity remains unclear. To address these gaps, this study utilizes iPSC-derived cerebral organoids (COs) from BD patients healthy controls model disease-specific metabolic in physiologically relevant system. COs exhibited impairment, dysregulated function, increased nod-leucine rich repeat pyrin domain containing protein 3...
The role of superoxide dismutase manganese dependent enzyme (SOD2) in colorectal cancer is presently insufficiently understood. Some studies suggest that high SOD2 levels found tissues are associated with progression. However, thus far, the superoxide-hydrogen peroxide imbalance has not yet been studied. Thus, order to address this gap extant literature, we performed an vitro analysis using HT-29 cell line exposed paraquat, which generates levels, and porphyrin, a mimic molecule. effect...
We investigated the in vitro effects of guaraná and its main metabolites (caffeine, theobromine catechin) on cytotoxicity cell proliferation colorectal cancer (CRC) line HT-29 cells oxaliplatin sensitivity. The were exposed to different concentrations extract with without oxaliplatin. bioactive molecules also estimated considering their potential proportion hydro-alcoholic extract. Apoptosis effect was analyzed by annexin V quantification using flow cytometry, while apoptosis pathway gene...
Cancer is considered a multifactorial disease and its development could be associated with several factors, for example, rotenone exposition. Unfortunately, many cancers are resistant to chemotherapy, as cervical cancer. Regarding this, lemongrass remarkable natural product that presents antioxidant anticancer activities, which show therapeutic action against Thus, this study aimed investigate the of lemongrass. An in vitro was conducted using VERO (kidney cells) SiHa cell lines (cervical...
SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) is the etiological agent responsible for global outbreak of COVID-19 (Coronavirus Disease 2019). The main protease SARS-CoV-2, Mpro, a key enzyme that plays vital role in mediating viral replication and transcription. In this study, comprehensive computational approach was employed to investigate binding affinity, selectivity, stability natural product candidates as potential new antivirals acting on polyprotein processing mediated...
Tucuma (Astrocaryum aculeatum) is an Amazonian fruit that presents high levels of carotenoids and other bioactive compounds such as quercetin. The extracts tucuma peel pulp present strong antioxidant activity which illustrate elevated concentration causes cytotoxic effects in human peripheral blood mononuclear cells (PBMCs). This study performed additional investigations to analyze the potential genotoxic on PBMCs. genotoxicity was evaluated by DNA fragmentation, Comet assay, chromosomal...
The mammalian target of rapamycin (mTOR) and mitogen-activated protein kinases (MAPKs) pathways are frequently upregulated in cancer. Some authors have reported that some antioxidant molecules could be potential inhibitors these pathways. Therefore, we investigated the vitro antitumor effect guaraná by inhibiting AKT/mTOR/S6K MAPKs Colorectal breast cancer cell lineages, HT-29 MCF-7 cells, respectively, were exposed to different concentrations (0.1, 1, 10, 100 µg/mL) as well its main...
Previous studies suggested that certain plants, such as guarana (Paullinia cupana), exert a protective effect against cancer‑related fatigue in breast cancer patients undergoing chemotherapy. However, possesses bioactive molecules, caffeine and catechin, which may affect the pharmacological properties of antitumor drugs. Therefore, aim this study was to evaluate effects on cell response 7 chemotherapeutic agents currently used treatment cancer. To perform study, MCF‑7 cells were cultured...