A5040357676- Phytochemicals and Antioxidant Activities
- Phytochemistry Medicinal Plant Applications
- Natural product bioactivities and synthesis
- Tryptophan and brain disorders
- Agricultural and Food Sciences
- Phytochemistry and Biological Activities
- Natural Antidiabetic Agents Studies
- Antioxidant Activity and Oxidative Stress
- Neurological Disease Mechanisms and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Pharmaceutical Quality and Counterfeiting
- Seaweed-derived Bioactive Compounds
- Therapeutic Uses of Natural Elements
- Cancer, Stress, Anesthesia, and Immune Response
- Digestive system and related health
- Laser Applications in Dentistry and Medicine
- Plant tissue culture and regeneration
- Ginkgo biloba and Cashew Applications
- Eicosanoids and Hypertension Pharmacology
- Photodynamic Therapy Research Studies
- Cholesterol and Lipid Metabolism
- Advances in Cucurbitaceae Research
- Phytochemical compounds biological activities
- Pineapple and bromelain studies
- Inflammasome and immune disorders
Universidade Franciscana
2021-2025
Universidade Federal de Santa Maria
2014-2025
University of Toronto
2023-2024
Inflammasome activation plays a critical role in lung inflammation, with the NLRP3 (NOD, LRR and pyrin domain-containing protein 3) inflammasome serving as key mediator of inflammatory cytokine release pyroptotic cell death. This study investigates effects bioactive flavonoid extract (BFE), potential modulator NLRP3-mediated inflammation using THP-1 derived macrophages, A549 cells (2D cells), organoids (3D cells). Cells were primed lipopolysaccharide (LPS), treated BFE, then activated...
Bipolar disorder (BD) is increasingly recognized as a with both mitochondrial dysfunction and heightened inflammatory reactivity, yet their contribution to neuronal activity remains unclear. To address these gaps, this study utilizes iPSC-derived cerebral organoids (COs) from BD patients healthy controls model disease-specific metabolic in physiologically relevant system. COs exhibited impairment, dysregulated function, increased nod-leucine rich repeat pyrin domain containing protein 3...
Neuropsychiatric diseases are responsible for one of the highest burden morbidity and mortality worldwide. These illnesses include schizophrenia, bipolar disorder, major depression. Individuals affected by these may present mitochondrial dysfunction oxidative stress. Additionally, patients also have increased peripheral neural chronic inflammation. The Brazilian fruit, açaí, has been demonstrated to be a neuroprotective agent through its recovery complex I activity. This extract previously...
The antioxidant capacity of the crude extract and fractions Tabernaemontana catharinensis fruits branches, was evaluated by 2,2-diphenyl-1-picrylhydrazyl (DPPH) method content polyphenols, flavonoids, alkaloids condensed tannins were determined spectrophotometric method. ethyl acetate fraction n-butanol branches showed IC50 181.82 µg/mL 78.19 µg/mL, respectively. All analyzed high performance liquid chromatography (HPLC), in quantified chlorogenic acid chloroform (8.96 mg/g), (4.31 mg/g)...
The neuroinflammatory process is considered one of the main characteristics central nervous system diseases, where a pro-inflammatory response results in oxidative stress through generation reactive oxygen and nitrogen species (ROS RNS). Olive (Olea europaea L.) pomace by-product olive oil production that rich phenolic compounds (PCs), known for their antioxidant anti-inflammatory properties. This work looked at anti-neuroinflammatory effects bioavailable PC from cell-free models microglia...
Inflammation is a vital mechanism that defends the organism against infections and restores homeostasis. However, when inflammation becomes uncontrolled, it leads to chronic inflammation. The NLRP3 inflammasome crucial in inflammatory responses has become focal point research for new anti-inflammatory therapies. Flavonoids like catechin, apigenin, epicatechin are known their bioactive properties (antioxidant, anti-inflammatory, etc.), but mechanisms behind actions remain unclear. This study...
The objective of this work was to produce and characterise nanoemulsions containing tucumã extract evaluate the performance nanostructure free compound regarding antitumor activity, cytotoxicity, oxidative metabolism in NB4/APL cells. showed adequate physicochemical characteristics (average size approx. 200 nm, polydispersity index less than 0.3, negative zeta potential acid pH) maintained stable up 90 days storage refrigeration condition. nanoformulations did not present protein corona...
Abstract Paenibacillus larvae is the causative agent of American Foulbrood (AFB ), a severe disease that affects honeybees. The use plant extracts are considered to be an alternative way controlling disease. In this study, in vitro antimicrobial activity Buddleja thyrsoides Lam. against species, including P. larvae, was evaluated. Mueller-Hinton broth, minimal inhibitory concentration (MI C) assessed using microdilution method. All species were sensitive crude extract and fractions B....
The aim of this study was to evaluate the toxicity tucumã oil nanocapsules from Amazon region in silver catfish, Rhamdia quelen. Fish were exposed water treated with different concentrations nanocapsules, white, solubilized and surfactant vehicles. After three days exposure, fish euthanized liver, gills brain removed for analysis dichlorofluorescein, nitric oxide PicoGreen® assays. Plasma collected assay hepatic transaminases. had a diameter 221 ± 1.27 nm, confirmed by atomic force...
Randia ferox is a Brazilian native species used in folk medicine. Scientific information regarding the toxicology and phytochemistry of this plant remains unclear. We aimed to produce R. extract, identify its chemical matrix, evaluate safety profile. The extract composition was accessed through UHPLC-MS/MS. Mononuclear cells, erythrocytes, fibroblasts, macrophages, kidney cells were subjected concentration-response curve testing. cellular viability, proliferation, dsDNA release, reactive...
The high consumption of dietary supplements was a fundamental driver for the creation regulatory framework by Brazilian governmental authorities. However, agencies lack official low-cost methodologies to evaluate quality food supplements. A preliminary screening method HPLC-DAD proposed and validated quantification adulterants in limits detection were <0.11 0.37 µg.g−1, respectively. applied investigation ten unauthorized substances (spironolactone, hydrochlorothiazide, furosemide,...
Neuropsychiatric diseases, such as bipolar disorder, Alzheimer’s, and Parkinson’s disease, are related to mitochondrial dysfunction chronic inflammatory activation, affecting thousands of people worldwide. Therefore, new alternative therapies with modulation anti-inflammatory effects, especially involving natural agents important search. Harpagophytum procumbens is a notable candidate. It an African plant action. The objective this study was evaluate the anti-neuroinflammatory effect H....
Nos dias de hoje, incontáveis estudos sobre produtos origem natural e seus benefícios são realizados. Nesse contexto, insere-se o açaí (Euterpe oleracea Mart.), um fruto com inúmeras moléculas bioativas que tem importante papel atribuído ao efeito antioxidante potencial anti-inflamatório. Devido a isso, é extrema importância análise prévia ensaios in vivo efeitos bioativos cientificamente já identificados, pelo uso ferramentas computacionais. No presente trabalho, tal avaliação foi realizada...