A5091364705- Phytochemicals and Antioxidant Activities
- Antioxidant Activity and Oxidative Stress
- Bee Products Chemical Analysis
- Natural Antidiabetic Agents Studies
- Fermentation and Sensory Analysis
- Paraoxonase enzyme and polymorphisms
- Phytochemistry Medicinal Plant Applications
- Heavy Metal Exposure and Toxicity
- Essential Oils and Antimicrobial Activity
- Diet, Metabolism, and Disease
- Mercury impact and mitigation studies
- Allelopathy and phytotoxic interactions
- Horticultural and Viticultural Research
- Insect and Pesticide Research
- Vitamin C and Antioxidants Research
- Cholesterol and Lipid Metabolism
- Free Radicals and Antioxidants
- Meat and Animal Product Quality
- Mitochondrial Function and Pathology
- Nutritional Studies and Diet
- Fatty Acid Research and Health
- Proteins in Food Systems
- Phytochemicals and Medicinal Plants
- Moringa oleifera research and applications
- Air Quality and Health Impacts
Universidade Federal de Santa Maria
2015-2025
Universidade Franciscana
2021
Departamento de Ciência e Tecnologia
2011
Universidade Federal do Rio Grande do Sul
2009
Center for Agricultural Research
2007
This study explored the effects of antioxidant astaxanthin on paraoxonase and thioredoxin reductase activities as well other oxidative stress parameters lipid profile in hypercholesterolemic rabbits. Rabbits were fed a standard or diet alone supplemented with 50, 100 500 mg/100 g for 60 days. Antioxidant enzymes activities, markers evaluated serum. The increased lipids, including unsaturated fatty acids level, whereas it decreased saturated level. These changes accompanied by levels oxidized...
The present study investigated the effects of oral administration annatto carotenoids (bixin (BIX) and norbixin (NBIX)) on glucose levels, lipid profiles, oxidative stress parameters in streptozotocin (STZ)-induced diabetic rats. Animals were treated for 30 days following groups: nondiabetic control, vehicle, 10 mg/kg BIX, 100 NBIX, metformin, insulin. Blood glucose, LDL cholesterol, triglyceride levels reduced rats with BIX. BIX treatment prevented protein oxidation nitric oxide production...
Eugenia involucrata DC. (Myrtaceae) is a native tree species from Brazil that has been scarcely studied. We investigated the phenolic composition, antioxidant capacity and antitumoral activity of ethanolic extracts fruits (FE) seeds (SE) E. involucrata. Six anthocyanins were identified by UPLC-PDA/MS/MS in FE, being four derived cyanidin, other ones delphinidin pelargonidin. Using HPLC-PDA, FE presented larger number compounds (epicatechin, catechin, rutin, ellagic acid, myricetin quercetin)...
Polyunsaturated fatty acids (PUFAs), especially the n-3 series, are known for their protective effects. Considering that cardiovascular diseases risk factors dementia, which is common at aging, aim of this study was to evaluate whether acid status in elderly associated with cognitive function and risk. Forty-five persons (age ≥60 years) were included divided into two groups based on Mini-Mental Status Examination score adjusted educational level: case group (n = 12) control 33). Serum...
Abstract: Oxidative stress is an important molecular mechanism for kidney injury in mercury poisoning. We studied lycopene, a potent carotenoid found tomatoes due to its large antioxidant properties, and also evaluated the ability of lycopene prevent HgCl 2 nephrotoxicity. Rats were injected with (0 or 5 mg/kg body weight, subcutaneously) 6 hr after administration (0, 10, 25 50 by gavage) killed 12 exposure. ‐induced inhibition δ‐aminolevulinate dehydratase activity (∼35%) increase lipid...
Pre-harvest sprouting is a frequent problem for wheat culture that can be simulated by laboratory-based germination. Despite reducing baking properties, has been shown to increase the bioavailability of some nutrients. It was investigated whether cultivars bearing distinct grain texture characteristics (BRS Guaraim, soft vs. BRS Marcante, hard texture) would have different behavior in terms changes phytochemical compounds during Using LC-Q-TOF-MS, higher contents benzoxazinoids and...
The aim of this study was to evaluate the effect annatto carotenoids intake associated a single high-calorie meal (high fat and high carbohydrate) in postprandial biochemical, inflammatory oxidative stress markers. Twelve healthy subjects (6 men, 6 women) were included randomised, controlled crossover study. Baseline blood samples collected from fasting that immediately received without carotenoid (placebo) or containing 1.2mg/kg bixin (BIX) 0.06mg/kg norbixin (NBIX). Blood taken 60, 120...
Abstract: Oxidative stress has been suggested to be an important molecular mechanism of toxic effects lead in the kidney. Thioredoxin reductase‐1 is a selenoprotein involved many cellular redox processes. This study evaluated effect acute and chronic exposure intraperitoneally acetate on thioredoxin activity other oxidative parameters rat kidney, as well indicators renal function commonly used assess poisoning. Acute 25 mg/kg increased superoxide dismutase (after 6, 24 48 hr), while 50...
Consumption of energy‐dense/high‐fat diets is strongly and positively associated with overweight obesity, which are increase in the prevalence certain chronic diseases. We evaluated effect hypercaloric/fat or normocaloric on some biochemical parameters rats. Seventy‐two rats were divided into four groups that fed for 16 weeks diets: [9.12% soy oil, oil (NSO)], hypercaloric olive [43.8% (HOO)], saturated fat fat, (HSF)] (NSF)]. HSF consumed more calories daily than others gained...
Opioids are addictive drugs, whose misuse evoke withdrawal and relapse. Mediterranean-based diet (MBD) is rich in n-3 polyunsaturated fatty acids (PUFA), while Western based diets (WBDs) contain saturated including interesterified fat (IF) palm oil (PO), influencing neural functions. We compared MBD WBDs on morphine-induced addiction parameters. Rats fed with (chow plus 20% soybean- fish-oil- n-6/n-3 PUFA 1:1) or WBD (WBD- PO WBD-IF: chow of fat, respectively; high ratio) were exposed to...
Natural products are often used by the population to treat and/or prevent several disorders. Tucumã is an Amazonian fruit widely consumed local and no in vivo toxicity studies regarding its safety available literature date. Therefore, phytochemical characterization, acute repeated dose 28-day oral toxicities of crude extract tucumã's pulp (CETP) Wistar rats were evaluated. For CETP preparation, tucumã was crushed placed into sealed amber glass jars containing absolute ethanol solution for...
We evaluated whether carotenoid astaxanthin (ASX) could prevent oxidative and atherosclerotic damage in rabbits. Rabbits received regular chow (control) or an atherogenic diet (1% cholesterol) alone supplemented with 50, 100, 500 mg% ASX for 60 days (n = 5-9 per group). The increased the serum cholesterol levels ratio of intima/media area aortic arch. These changes were not prevented by ASX. Atherosclerotic rabbits showed lipid peroxidation nonprotein thiol group (NPSH) along inhibition...
Free radicals production and oxidative stress play a central role in injuries caused by ethanol (EtOH) on gastric mucosal. Thus, strategies to counteract EtOH toxicity are highly desirable. This study was aimed at evaluating whether Vernonia cognata extract would reduce effects rats. Rats received (0, 1 2 g/kg bw, gavage) hour after had been administered (0 or 70%, 0.5 mL/100 g were killed administration. The stomach removed for macroscopic histopathological evaluation, as well as, markers...
Abstract Background There is a relationship among hypercholesterolemia, oxidative stress and inflammation in the atherogenesis. Thus, objective of present study was to assess paraoxonase (PON1), superoxide dismutase (SOD) thioredoxin reductase (TrxR-1) activities their with lipids, subjects different low density lipoprotein-cholesterol (LDL) levels. Methods Serum highly sensitive C-reactive protein (hs-CRP), lipid oxidation, oxidized LDL (LDLox) LDLox autoantibodies (LDLoxAB) levels enzymes...
Lycopene-based medications and supplements have been developed to prevent atherosclerosis, primarily because of their ability decrease low-density lipoprotein (LDL) oxidation. Bixin norbixin are carotenoids found in the seeds annatto (Bixa orellana) colorants widely used by food industry. Some studies already demonstrated that these compounds antioxidant antiatherogenic potential vitro animal models, but there is no evidence supporting effects long-term or short-term consumption humans. The...