A5078555594- Advanced Glycation End Products research
- S100 Proteins and Annexins
- Alzheimer's disease research and treatments
- Muscle metabolism and nutrition
- Diet and metabolism studies
- Biochemical effects in animals
- Stress Responses and Cortisol
- Adipose Tissue and Metabolism
- Neuroscience and Neuropharmacology Research
- Metabolism and Genetic Disorders
- Sports Performance and Training
- Connexins and lens biology
- Body Composition Measurement Techniques
- Neuroinflammation and Neurodegeneration Mechanisms
- Thermoregulation and physiological responses
- Diet, Metabolism, and Disease
- Nutritional Studies and Diet
- Tryptophan and brain disorders
- Pharmacological Effects and Toxicity Studies
- Exercise and Physiological Responses
- Ion channel regulation and function
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Folate and B Vitamins Research
- Vitamin D Research Studies
- Long-Term Effects of COVID-19
Universidade Federal de Santa Catarina
2018-2025
Universidade Federal do Rio Grande do Sul
2009-2024
Hospital de Clínicas de Porto Alegre
2018-2024
Universidade de Passo Fundo
2013
Roskilde Sygehus
1980
Although inflammation may be a physiological defense process, imbalanced neuroinflammation has been associated with the pathophysiology of brain disorders, including major depression and schizophrenia. Activated glia releases variety pro-inflammatory cytokines that contribute to neuronal dysfunction. Elevated levels S100B, derived protein, have observed in serum CSF schizophrenic patients suggesting glial role disease. We evaluated whether S100B secretion (in C6 glioma cells hippocampal...
Temporal lobe epilepsy (TLE) is the most common form of partial and accompanied, in one third cases, by resistance to antiepileptic drugs (AED). Most AED target neuronal activity modulated ionic channels, steroid sensitivity these channels has supported use corticosteroids as adjunctives AED. Assuming importance astrocytes activity, we investigated inflammatory astroglial markers hippocampus, a key structure affected TLE Li-pilocarpine model epilepsy.Initially, hippocampal slices were...
<title>Abstract</title> <bold>Background: </bold>Vitamin D is of vital importance for bone health and also regulates inflammatory cytokines, which contribute to immune signaling defenses. It possible that physical activity could influence serum 25(OH)D levels, it has been suggested exercise can increase concentration. The aim this study was investigate the association between biomarkers concentration in a sample Brazilian adults, taking into account on association. <bold>Methods: </bold>This...
Diabetes is associated with loss of cognitive function and increased risk for Alzheimer's disease (AD). Advanced glycation end products (AGEs) are elevated in diabetes AD have been suggested to act as mediators the decline observed these pathologies. Methylglyoxal (MG) an extremely reactive carbonyl compound that propagates reactions is, therefore, able generate AGEs. Herein, we evaluated persistent behavioral biochemical parameters explore hypothesis exogenous MG concentrations, induced by...
O-GlcNAc transferase (OGT), an enzyme highly expressed in brain tissue, catalyzes the addition of N-acetyl-glucosamine (GlcNAc) to hydroxyl residues serine and threonine proteins. Brain protein O-GlcNAcylation is diminished Alzheimer's disease (AD), OGT targets include proteins insulin-signaling pathway (e.g., insulin receptor susbtrate-1, IRS-1). We hypothesized that ICV streptozotocin (STZ) also affects modification. investigated hippocampal metabolic changes Wistar rats, particularly...
Homocystinuria is a neurometabolic disease caused by severe deficiency of cystathionine beta-synthase activity, resulting in hyperhomocysteinemia. Affected patients present several symptoms including variable degree motor dysfunction. In this study, we investigated the effect chronic hyperhomocysteinemia on cell viability mitochondrion, as well some parameters energy metabolism, such glucose oxidation and activities pyruvate kinase, citrate synthase, isocitrate dehydrogenase, malate...
Intraneuronal aggregates of neurofibrillary tangles (NFTs), together with beta-amyloid plaques and astrogliosis, are histological markers Alzheimer's disease (AD). The underlying mechanism sporadic AD remains poorly understood, but abnormal hyperphosphorylation tau protein is suggested to have a role in NFTs genesis, which leads neuronal dysfunction death. Okadaic acid (OKA), strong inhibitor phosphatase 2A, has been used induce dementia similar rats. We herein investigated the effect...
Consumption of energy‐dense/high‐fat diets is strongly and positively associated with overweight obesity, which are increase in the prevalence certain chronic diseases. We evaluated effect hypercaloric/fat or normocaloric on some biochemical parameters rats. Seventy‐two rats were divided into four groups that fed for 16 weeks diets: [9.12% soy oil, oil (NSO)], hypercaloric olive [43.8% (HOO)], saturated fat fat, (HSF)] (NSF)]. HSF consumed more calories daily than others gained...
The impairment of astrocyte functions is associated with diabetes mellitus and other neurodegenerative diseases. Astrocytes have been proposed to be essential cells for neuroprotection against elevated levels methylglyoxal (MG), a highly reactive aldehyde derived from the glycolytic pathway. MG exposure impairs primary viability, as evaluated by different assays, these respond elevation increasing glyoxalase 1 activity glutathione levels, which improve cell viability survival. However, C6...
Abstract Background The COVID-19 pandemic remains ongoing, with a significant number of survivors who have experienced moderate to severe clinical conditions and suffered losses great magnitude, especially in functional capacity, triggering limitations daily autonomy quality life. Among the possibilities intervention for disease rehabilitation, physical exercise training stands out, which can benefit several health outcomes favours adoption healthier behaviours. Therefore, aim study will be...
Aquaporin-4 (AQP-4) is the principal brain water channel and predominantly expressed in astrocytes suggesting its dynamic involvement homeostasis tissue. Due to co-localization of AQP-4 inward rectifier K+ channels Kir 4.1, a functional coupling between these proteins has been proposed. putative role physiopathology disorders including epilepsy trauma. S100B calcium-binding protein secreted by astrocytes, commonly used as parameter astroglial activation. Here, we investigate possible link...
Depression and anxiety play an important role in decreasing quality of life worldwide. Since tryptophan is a serotonin precursor low levels seems to be related depression, the effect oral has been investigated for possible potentiation action antidepressant drugs. We effects chronically administered (50mg/kg/day, p.o.) with or without concomitant fluoxetine (10mg/kg/day, s.c.) on adult rats regarding depression-related anxiety-like behaviors. Tryptophan cerebrospinal fluid (CSF) were...