A5075312734- S100 Proteins and Annexins
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- Biochemical effects in animals
- Alzheimer's disease research and treatments
- Stress Responses and Cortisol
- Advanced Glycation End Products research
- Epilepsy research and treatment
- Intracerebral and Subarachnoid Hemorrhage Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Anesthesia and Neurotoxicity Research
- Zebrafish Biomedical Research Applications
- Nerve injury and regeneration
- Spinal Cord Injury Research
- Mitochondrial Function and Pathology
- Connexins and lens biology
- Pain Mechanisms and Treatments
- Diet and metabolism studies
- Neurogenesis and neuroplasticity mechanisms
- Dental Trauma and Treatments
- Acute Ischemic Stroke Management
- Mesenchymal stem cell research
- Tryptophan and brain disorders
- Neonatal and fetal brain pathology
- Vestibular and auditory disorders
Universidade Federal do Rio Grande do Sul
2014-2025
Instituto Biológico
2013
Neuroinflammation is a common feature during the development of neurological disorders and neurodegenerative diseases, where glial cells, such as microglia astrocytes, play key roles in activation maintenance inflammatory responses central nervous system. now known to involve neurometabolic shift, addition an increase energy consumption. We used two approaches (in vivo ex vivo) evaluate effects lipopolysaccharide (LPS)-induced neuroinflammation on reprogramming, modulation glycolytic pathway...
Stem cells from human exfoliated deciduous teeth (SHED) transplants have been investigated as a possible treatment strategy for spinal cord injuries (SCI) due to their potential promoting functional recovery. The aim of present study was investigate the effects SHED on neuronal death after an experimental model SCI. Methods: Wistar rats were spinalized using NYU impactor®. Animals randomly distributed into 4 groups: Control (Naive) or Surgical control, Sham (laminectomy with no SCI); SCI...
Temporal lobe epilepsy (TLE) is the most common form of partial and accompanied, in one third cases, by resistance to antiepileptic drugs (AED). Most AED target neuronal activity modulated ionic channels, steroid sensitivity these channels has supported use corticosteroids as adjunctives AED. Assuming importance astrocytes activity, we investigated inflammatory astroglial markers hippocampus, a key structure affected TLE Li-pilocarpine model epilepsy.Initially, hippocampal slices were...
O-GlcNAc transferase (OGT), an enzyme highly expressed in brain tissue, catalyzes the addition of N-acetyl-glucosamine (GlcNAc) to hydroxyl residues serine and threonine proteins. Brain protein O-GlcNAcylation is diminished Alzheimer's disease (AD), OGT targets include proteins insulin-signaling pathway (e.g., insulin receptor susbtrate-1, IRS-1). We hypothesized that ICV streptozotocin (STZ) also affects modification. investigated hippocampal metabolic changes Wistar rats, particularly...
We investigated the effects of ketogenic diet (KD) on levels tumor necrosis factor alpha (TNF-α, a classical pro-inflammatory cytokine), BDNF (brain-derived neurotrophic factor, commonly associated with synaptic plasticity), and S100B, an astrocyte cytokine involved in metabolism regulation.Young Wistar rats were fed during 8weeks control or two KD, containing different proportions omega 6 3 polyunsaturated fatty acids. Contents TNF-α, S100B measured by ELISA brain regions (hippocampus...
The impairment of astrocyte functions is associated with diabetes mellitus and other neurodegenerative diseases. Astrocytes have been proposed to be essential cells for neuroprotection against elevated levels methylglyoxal (MG), a highly reactive aldehyde derived from the glycolytic pathway. MG exposure impairs primary viability, as evaluated by different assays, these respond elevation increasing glyoxalase 1 activity glutathione levels, which improve cell viability survival. However, C6...
Neonatal hypoxia ischemia (HI) plays a role in the etiology of several neurological pathologies and causes severe sequelae. Acetylcholine is neurotransmitter central nervous system cholinesterase inhibitors have demonstrated positive action over HI induced deficits. In order to evaluate effects pre post-hypoxia administrations galantamine, inhibitor, model perinatal HI, Wistar rats post-natal day 7 (PND7) were subjected combination unilateral occlusion right carotid artery with exposure 1h...
Objectives The hypothalamus plays critical roles in maintaining brain homeostasis and increasing evidence has highlighted astrocytes orchestrating several of hypothalamic functions. However, it remains unclear how participate neurochemical mechanisms associated with aging process, as well whether these cells can be a target for antiaging strategies. In this sense, the aim study is to evaluate age-dependent effects resveratrol, well-characterized neuroprotective compound, primary astrocyte...