A5002728403- Zebrafish Biomedical Research Applications
- Neuroscience and Neuropharmacology Research
- Natural Language Processing Techniques
- Metabolism and Genetic Disorders
- Translation Studies and Practices
- Neuroendocrine regulation and behavior
- Stress Responses and Cortisol
- Subtitles and Audiovisual Media
- Fish biology, ecology, and behavior
- Mitochondrial Function and Pathology
- Fish Ecology and Management Studies
- Epilepsy research and treatment
Universidade Federal do Rio Grande do Sul
2013-2021
Pentylenetetrazole (PTZ) is a common convulsant agent used in animal models to investigate the mechanisms of seizures. Although adult zebrafish have been recently study epileptic seizures, thorough characterization PTZ-induced seizures this model missing. The goal was perform detailed temporal behavior profile seizure zebrafish. behavioral during 20 min PTZ immersion (5, 7.5, 10, and 15 mM) characterized by stages defined as scores: (0) short swim, (1) increased swimming activity high...
Anxiety-related disorders are frequently observed in the population. Because available pharmacotherapies for anxiety can cause side effects, new anxiolytic compounds have been screened using behavioral tasks. For example, diphenyl diselenide (PhSe)2, a simple organoselenium compound with neuroprotective has demonstrated effects rodents. However, this not yet tested novelty-based paradigm non-mammalian animal models. In study, we assessed potential of (PhSe)2 on behavior adult zebrafish under...
Background: Epilepsy is a chronic disorder of the brain. Globally, an estimated 2.4 million people are diagnosed with epilepsy each year. Recent studies have shown that 70% epileptic patients can be successfully treated anti-epileptic drugs. Unfortunately, 30% still suffer from intractable epilepsy, problem represents difficult scientific challenge. Crucial genetic research and high throughput drug screening combined together to search for treatment refractory seizures. Goals. Development...