A5010182711- Sulfur-Based Synthesis Techniques
- Organoselenium and organotellurium chemistry
- Asymmetric Synthesis and Catalysis
- Synthesis and Catalytic Reactions
- Chemical Synthesis and Analysis
- Chemical Synthesis and Reactions
- Catalytic C–H Functionalization Methods
- Organic Chemistry Cycloaddition Reactions
- Radical Photochemical Reactions
- Asymmetric Hydrogenation and Catalysis
- Photochemistry and Electron Transfer Studies
- Synthesis and biological activity
- Synthesis and Reactivity of Heterocycles
- Click Chemistry and Applications
- Fluorine in Organic Chemistry
- Synthetic Organic Chemistry Methods
- Photochromic and Fluorescence Chemistry
- Synthesis and Properties of Aromatic Compounds
- Liquid Crystal Research Advancements
- Catalytic Cross-Coupling Reactions
- Multicomponent Synthesis of Heterocycles
- Synthesis and Reactions of Organic Compounds
- Inorganic and Organometallic Chemistry
- Crystallization and Solubility Studies
- Luminescence and Fluorescent Materials
Universidade Federal do Rio Grande do Sul
2016-2025
Pontificia Universidad Católica de Chile
2021
Universidade de Passo Fundo
2012-2016
Universidade Federal de São Carlos
2016
Universidade Nove de Julho
2016
Microsoft (Brazil)
2016
Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde
2016
Universidade Federal de Pelotas
2014-2015
Universität Innsbruck
2005-2015
Universidade Feevale
2009-2014
A simple and efficient procedure for the synthesis of a new class selenoesters 4a 4b was developed. Polarized-light optical microscopy (POM), differential scanning calorimetry (DSC), X-ray diffraction showed that selenoester with shorter alkyl chain displayed wide nematic range (ΔT = 110.7 °C), while longer possesses rich phase polymorphism: Cr → SmI SmC N I mesophase sequence during heating cycle SmX transition on cooling. For 4b, large temperature (135.7 °C) from crystal to isotropic can...
An eco-friendly multicomponent reaction for the synthesis of 1,2,3-triazoles using a recoverable and recyclable Cu/SiO<sub>2</sub> composite as catalyst is reported.
A simple and regiospecific synthesis of 4-alkoxy(amino)-2-trifluoromethyl pyrroles from 5-azido-4-alkoxy(amino)-1,1,1-trifluoro-pent-3-en-2-ones by an aza-Wittig cyclization aminophosphoranes is described. The structures the their synthetic intermediates were supported NMR HRMS analysis.
A simple and efficient procedure for the synthesis of chiral beta-seleno-amines derivatives from a one-pot indium(I) iodide-mediated aziridine ring opening with diorganoyl diselenides has been developed. As an application, selenocysteine selenotreonine accomplished.
The formation and 2-amino alcohol catalyzed addition of arylzinc reagents from with boronic acids, respectively, is drastically accelerated to a few minutes under microwave irradiation without loss enantioselectivity (up 98% ee). Of the amino acid derived catalysts tested, conformationally restricted bulky substituted aziridine-2-methanols serine show best overall performance in diarylmethanols.
This paper reports the results of an intervention study which assessed effects compensatory vestibular-proprioceptive stimulation provided by waterbed flotation on neurobehavioral development preterm infants. The subjects, who were randomly assigned to experimental and control groups before they four days old, consisted infants ventilators for severe RDS. Twenty tested with a new assessment procedure when between 34 35 weeks conceptional age. examiner, pediatric neurologist, was unaware...
An efficient and convenient method was developed for the regioselective formation of 2-aryl- or 2,5-diarylselenophenes via a palladium-catalyzed direct arylation. This protocol is suitable wide range aryl halides containing different functional groups. The 2-arylated substrates can undergo an additional arylation event furnishing symmetrical unsymmetrical 2,5-diaryl selenophenes in good yield. Competition experiments role acid additive are agreement with concerted metalation deprotonation...
Bis-arylsulfenyl- and bis-arylselanyl-benzo-2,1,3-thiadiazoles were synthesized in good yields by copper-catalysed cross-coupling reaction of arylthiols or diaryl diselenides with the commercially available 4,7-dibromobenzo[<italic>c</italic>][1,2,5]thiadiazole.
Recent outstanding advances in the C–Se bond formation through transition metalcatalysed direct selanylation, providing new insights into their mechanistic aspects, were provided this perspective.
The transition metal‐catalyzed direct C−S and C−Se bond formation from C−H bonds has emerged as an efficient synthetic strategy for constructing previously inaccessible organochalcogen compounds, opening a new gateway to late‐stage functionalization of pharmaceutical‐relevant molecules organic functional materials. C−Y (Y = S, Se, Te) also show outstanding strategic relevance handles access other valuable groups downstream in route. Despite the significant progress, chemo‐, site‐,...
Abstract A new approach for the one‐pot synthesis of alkynyl chalcogenides, exemplified mainly by selenides, was developed in which dual activation diorgano dichalcogenides and terminal acetylenes is achieved using an indium(III) catalyst. The method has advantages broad substrate scope, simple operation, mild reaction conditions, good yields. plausible mechanism proposed.
In this study, the antinociceptive, anti-hypernociceptive and toxic effects of orally administered (R)-Se-phenyl thiazolidine-4-carboselenoate (Se-PTC, 1–50 mg/kg) were evaluated in mice. Se-PTC did not change plasma aspartate (AST) alanine aminotransferase (ALT) activities or urea creatinine levels. Furthermore, an open field test, alter number crossings rearing. significantly reduced amount writhing when assessed by acetic acid-induced visceral nociception attenuated licking time injected...
A simple and efficient procedure for the synthesis of a new class organoselenium liquid crystal compounds was developed. The coupling aryl bromides with elemental selenium catalysed using copper oxide nanopowder in presence potassium hydroxide employing dimethyl sulfoxide as solvent. This is first report characterisation crystal-based diselenides. Their mesophases were characterised by polarising optical microscopy differential scanning calorimetry. Compounds 1, 2 4b exhibited smectic phase....
Anxiety-related disorders are frequently observed in the population. Because available pharmacotherapies for anxiety can cause side effects, new anxiolytic compounds have been screened using behavioral tasks. For example, diphenyl diselenide (PhSe)2, a simple organoselenium compound with neuroprotective has demonstrated effects rodents. However, this not yet tested novelty-based paradigm non-mammalian animal models. In study, we assessed potential of (PhSe)2 on behavior adult zebrafish under...
Thiazolidine and pyrrolidine compounds containing a thiourea moiety were prepared using boric acid as coupling agent in multicomponent methodology. In addition, the antioxidant activity, reflected by free radical scavenging, was evaluated. Some selected tested different experiments all of them shown to be useful for prevention oxidative stress biological systems thus capable reducing cellular injury.
A collection of isoxazoles derivatives has been efficiently synthesized in three steps. The oximation reaction aldehydes followed by nitrile oxide [3+2] 1,3-dipolar cycloaddition and MnO2-oxidation furnished the title compounds which were purified simple filtration on celite®.
Abstract We report a general, practical, and simple metal‐free method for the synthesis of 2‐substituted 1,3‐benzoselenazoles by reaction bis(2‐aminophenyl)diselenide with wide range carboxylic acids, promoted tributylphosphine. This efficient furnishes 2‐aryl‐1,3‐benzoselenazoles in good yields tolerates variety substituents at aryl moiety acids. For first time, 2‐alkyl‐1,3‐benzoselenazoles could be obtained from aliphatic acids thiazolidine‐4‐carboxylic acid high chemical yields. The use...