A5014804546- Organoselenium and organotellurium chemistry
- Selenium in Biological Systems
- Mercury impact and mitigation studies
- Heavy Metal Exposure and Toxicity
- Sulfur Compounds in Biology
- Cholinesterase and Neurodegenerative Diseases
- Free Radicals and Antioxidants
- Redox biology and oxidative stress
- Trace Elements in Health
- Pesticide Exposure and Toxicity
- Neuroscience and Neuropharmacology Research
- Phytochemicals and Antioxidant Activities
- Science and Education Research
- Biochemical effects in animals
- Antioxidant Activity and Oxidative Stress
- Computational Drug Discovery Methods
- Essential Oils and Antimicrobial Activity
- Organic Chemistry Cycloaddition Reactions
- Environmental Toxicology and Ecotoxicology
- Genomics, phytochemicals, and oxidative stress
- Porphyrin Metabolism and Disorders
- Insect and Pesticide Research
- Vitamin C and Antioxidants Research
- Synthesis and biological activity
- X-ray Diffraction in Crystallography
Universidade Federal de Santa Maria
2016-2025
Universidade Federal do Rio Grande do Sul
2006-2025
University of Minho
2004-2024
Polytechnic Institute of Castelo Branco
2024
City Clinical Hospital
2024
Universidad Nacional Autónoma de México
2024
California State University Los Angeles
2024
Universidade Federal do Tocantins
2024
Universidade Regional do Cariri
2012-2024
Centro Hospitalar do Tâmega e Sousa
2019-2023
Abstract: Sodium selenite (Na 2 SeO 3 ) is the selenium form used in composition of dietary supplements, and diphenyl diselenide (PhSe) an important intermediate organic synthesis, which increases risk human exposure to this chemical workplace. These compounds have been reported inhibit cerebral hepatic aminolevulinic acid dehydratase (ALA‐D) vitro , now we show that ascorbic can reverse some alterations caused by vivo exposure, but not ALA‐D inhibition. The effect Na or on distribution,...
Free radicals induce lipid peroxidation, playing an important role in pathological processes. The injury mediated by free can be measured conjugated dienes, malondialdehyde, 4-hydroxynonenal, and others. However, malondialdehyde has been pointed out as the main product to evaluate peroxidation. Most assays determine its reaction with thiobarbituric acid, which indirect (spectrometry) direct methodologies (chromatography). Though there is some controversy among methodologies, selective...
In this review, we summarized the potential role of synthetic organoseleno compounds as therapeutic or toxic agents, giving emphasis almost exclusively to diphenyl diselenide, simplest diaryl diselenides, and some its analogs. We presented main molecular aspects related in vitro toxicity pharmacology diselenide also provided vivo data indicating that interaction with thiols can dictate either toxicological pharmacological property. The papers covered review indicate a limited activation...