A5014634459- Trace Elements in Health
- Heavy Metal Exposure and Toxicity
- Selenium in Biological Systems
- Analytical chemistry methods development
- Heavy metals in environment
- Electrochemical Analysis and Applications
- Air Quality and Health Impacts
- Mercury impact and mitigation studies
- Radioactive element chemistry and processing
- Aluminum toxicity and tolerance in plants and animals
- Iron Metabolism and Disorders
- Vehicle emissions and performance
- Microfluidic and Capillary Electrophoresis Applications
- Mass Spectrometry Techniques and Applications
- Heavy Metals in Plants
- Arsenic contamination and mitigation
- Atmospheric chemistry and aerosols
- Radioactivity and Radon Measurements
- Maritime Transport Emissions and Efficiency
- Parkinson's Disease Mechanisms and Treatments
- Amyotrophic Lateral Sclerosis Research
- Chromium effects and bioremediation
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Alzheimer's disease research and treatments
Helmholtz Zentrum München
2016-2025
Center for Environmental Health
2008-2024
Goethe University Frankfurt
2024
Luxembourg Institute of Health
2023
Institute of Groundwater Ecology
1999-2022
Helmholtz Association of German Research Centres
2022
University of Wuppertal
2021
Institute for Ecological Economy Research
2006-2017
Helmholtz-Zentrum Berlin für Materialien und Energie
2016
Amt für Umwelt
1998-2007
Abstract. High-performance, non-target, high-resolution organic structural spectroscopy was applied to solid phase extracted marine dissolved matter (SPE-DOM) isolated from four different depths in the open South Atlantic Ocean off Angola coast (3° E, 18° S; Basin) and provided molecular level information with extraordinary coverage resolution. Sampling performed at of 5 m (Angola Current; near-surface photic zone), 48 fluorescence maximum), 200 (still above Antarctic Intermediate Water,...
<h3>Objective</h3> Iron deficiency is a common complication in patients with IBD and oral iron therapy suggested to exacerbate symptoms. We performed an open-labelled clinical trial compare the effects of per (PO) versus intravenous (IV) replacement (IRT). <h3>Design</h3> The study population included Crohn9s disease (CD; N=31), UC (N=22) control subjects (non-inflamed, NI=19). After randomisation, participants received sulfate or sucrose over 3 months. Clinical parameters, faecal bacterial...
Heavy fuel oil (HFO) particulate matter (PM) emitted by marine engines is known to contain toxic heavy metals, including vanadium (V) and nickel (Ni). The toxicity of such metals will depend on the their chemical state, size distribution, mixing state. Using online soot-particle aerosol mass spectrometry (SP-AMS), we quantified five (V, Ni, Fe, Na, Ba) in HFO-PM soot particles produced a diesel research engine. in-soot metal concentrations were compared in-PM
Abstract Multiple sclerosis (MS) is a chronic autoimmune disorder characterized by central nervous (CNS) demyelination resulting in axonal injury and neurological deficits. Essentially, MS driven an auto-amplifying mechanism of inflammation cell death. Current therapies mainly focus on disease modification immunosuppression, while no treatment specifically focuses controlling death injury. Here, we report that ferroptosis, iron-catalyzed mode regulated (RCD), contributes to progression....
The role of alveolar macrophages in the fate ultrafine particles lung was investigated. Male Wistar-Kyoto rats were exposed to gold particles, generated by a spark generator, for 6 h at concentration 88 μg/m3 (4 × 106/cm3, 16 nm modal mobility diameter). Up 7 days, animals serially sacrificed, and lavaged cells tissues examined transmission electron microscopy. concentration/content lung, lavage fluid, blood estimated inductively coupled plasma–mass spectrometry. Gold used spherical dense...
The chemical composition of particulate matter (PM) emissions from a medium-speed four-stroke marine engine, operated on both heavy fuel oil (HFO) and distillate (DF), was studied under various operating conditions. PM emission factors for organic matter, elemental carbon (soot), inorganic species variety compounds were determined. In addition, the molecular aromatic analyzed using novel coupling thermal-optical analyzer with resonance-enhanced multiphoton ionization (REMPI) mass...
Background Ship engine emissions are important with regard to lung and cardiovascular diseases especially in coastal regions worldwide. Known cellular responses combustion particles include oxidative stress inflammatory signalling. Objectives To provide a molecular link between the chemical physical characteristics of ship emission they elicit identify potentially harmful fractions shipping aerosols. Methods Through an air-liquid interface exposure system, we exposed human cells under...
Exposure to selenium, and particularly its inorganic forms, has been hypothesized as a risk factor for amyotrophic lateral sclerosis (ALS), fast progressing motor neuron disease with poorly understood etiology. However, no information is known about levels of some organic selenium species in the central nervous system ALS patients, recent observations suggest that peripheral biomarkers exposure are unable predict these several Se including forms. Using hospital-referred case-control series...
Little is known about factors influencing progression from mild cognitive impairment to Alzheimer's dementia. A potential role of environmental chemicals and specifically selenium, a trace element nutritional toxicological relevance, has been suggested. Epidemiologic studies selenium are lacking, however, with the exception recent randomized trial based on an organic form.We determined concentrations species in cerebrospinal fluid sampled at diagnosis 56 participants nonvascular origin. We...
BNIP3 is a mitophagy receptor with context-dependent roles in cancer, but whether and how it modulates melanoma growth vivo remains unknown. Here, we found that elevated levels correlated poorer patient's survival depletion of B16-F10 cells compromised tumor vivo. halted enforced PHD2-mediated downregulation HIF-1α its glycolytic program both vitro Mechanistically, BNIP3-deprived displayed increased intracellular iron caused by heightened NCOA4-mediated ferritinophagy, which fostered...
Ferroptosis has emerged as an attractive strategy in cancer therapy. Understanding the operational networks regulating ferroptosis may unravel vulnerabilities that could be harnessed for therapeutic benefit. Using CRISPR-activation screens hypersensitive cells, we identify selenoprotein P (SELENOP) receptor, LRP8, a key determinant protecting MYCN-amplified neuroblastoma cells from ferroptosis. Genetic deletion of LRP8 leads to result insufficient supply selenocysteine, which is required...
Excess copper causes hepatocyte death in hereditary Wilson's disease (WD). Current WD treatments by copper-binding chelators may gradually reduce overload; they fail, however, to bring hepatic close normal physiological levels. Consequently, lifelong daily dose regimens are required hinder progression. This result severe issues due nonadherence or unwanted adverse drug reactions and also switching ultimate treatment failures. study comparatively tested bacteria-derived binding...
Abstract The efficacy of antitumor immunity is associated with the metabolic state cytotoxic T cells, which sensitive to tumor microenvironment. Whether ionic signals affect adaptive immune responses unclear. In present study, we show that there an enrichment sodium in solid tumors from patients breast cancer. Sodium chloride (NaCl) enhances activation and effector functions human CD8 + enhanced fitness. These NaCl-induced effects translate into increased cell killing vitro vivo....
Due to the physico-chemical similarities of caesium (Cs(+)) potassium (K(+)) on one hand and strontium (Sr(2+)) calcium (Ca(2+)) other hand, both elements can easily be taken up by plants thus enter food chain. This could detrimental when radionuclides such as (137)Cs (90)Sr are involved. In this study, genetic physiological aspects Cs(+) Sr(2+) accumulation in Arabidopsis thaliana were investigated using 86 accessions a segregating F(2) population low accumulating Sq-1 (Ascot, UK) crossed...