A5032761867- Ferroptosis and cancer prognosis
- Cancer, Lipids, and Metabolism
- Redox biology and oxidative stress
- RNA modifications and cancer
- Selenium in Biological Systems
- Glutathione Transferases and Polymorphisms
- Trace Elements in Health
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- Sperm and Testicular Function
- Inflammatory mediators and NSAID effects
- Mitochondrial Function and Pathology
- Cholesterol and Lipid Metabolism
- Sulfur Compounds in Biology
- Genomics, phytochemicals, and oxidative stress
- Drug Transport and Resistance Mechanisms
- Endoplasmic Reticulum Stress and Disease
- Iron Metabolism and Disorders
- MicroRNA in disease regulation
- ATP Synthase and ATPases Research
- Nitric Oxide and Endothelin Effects
- Amino Acid Enzymes and Metabolism
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Circular RNAs in diseases
- Pregnancy and preeclampsia studies
Helmholtz Zentrum München
2016-2025
Target (Germany)
2023-2025
Technical University of Munich
2024-2025
Max Planck Institute of Biophysics
2024
Pirogov Russian National Research Medical University
2020-2023
ORCID
2021
Johannes Gutenberg University Mainz
2019
Institute of Genetics
2018
University of Würzburg
2018
Freie Universität Berlin
2017
Ferroptosis is a form of regulated necrosis associated with the iron-dependent accumulation lipid hydroperoxides that may play key role in pathogenesis degenerative diseases which peroxidation has been implicated. High-throughput screening efforts have identified ferrostatin-1 (Fer-1) and liproxstatin-1 (Lip-1) as potent inhibitors ferroptosis − an activity ascribed to their ability slow hydroperoxides. Herein we demonstrate this likely derives from reactivity radical-trapping antioxidants...
The selenoenzyme glutathione peroxidase 4 (Gpx4) is a major scavenger of phospholipid hydroperoxides. Although Gpx4 represents key component the reactive oxygen species-scavenging network, its relevance in immune system yet to be defined. Here, we investigated importance for physiological T cell responses by using cell-specific Gpx4-deficient mice. Our results revealed that, despite normal thymic development, CD8(+) cells from T(ΔGpx4/ΔGpx4) mice had an intrinsic defect maintaining...
High-risk neuroblastoma is a devastating malignancy with very limited therapeutic options. Here, we identify withaferin A (WA) as natural ferroptosis-inducing agent in neuroblastoma, which acts through novel double-edged mechanism. WA dose-dependently either activates the nuclear factor–like 2 pathway targeting of Kelch-like ECH-associated protein 1 (noncanonical ferroptosis induction) or inactivates glutathione peroxidase 4 (canonical induction). Noncanonical induction characterized by an...
Oxygen radicals regulate many physiological processes, such as signaling, proliferation, and apoptosis, thus play a pivotal role in pathophysiology disease development. There are at least two thioredoxin reductase/thioredoxin/peroxiredoxin systems participating the cellular defense against oxygen radicals. At present, relatively little is known about contribution of individual enzymes to redox metabolism different cell types. To begin address this question, we generated characterized mice...
Ferroptosis, a non-apoptotic form of cell death marked by iron-dependent lipid peroxidation1, has key role in organ injury, degenerative disease and vulnerability therapy-resistant cancers2. Although substantial progress been made understanding the molecular processes relevant to ferroptosis, additional cell-extrinsic cell-intrinsic that determine sensitivity toward ferroptosis remain unknown. Here we show fully reduced forms vitamin K-a group naphthoquinones includes menaquinone...