A5059608082- Endometriosis Research and Treatment
- Endometrial and Cervical Cancer Treatments
- Uterine Myomas and Treatments
- Ovarian cancer diagnosis and treatment
- Reproductive System and Pregnancy
- Cervical Cancer and HPV Research
- Global Health Care Issues
- Gynecological conditions and treatments
- Pelvic floor disorders treatments
- Intestinal and Peritoneal Adhesions
- Pregnancy-related medical research
- Estrogen and related hormone effects
- Anorectal Disease Treatments and Outcomes
- Angiogenesis and VEGF in Cancer
- Cancer survivorship and care
- Genital Health and Disease
- Breast Cancer Treatment Studies
- Healthcare Systems and Practices
- Minimally Invasive Surgical Techniques
- Hernia repair and management
- Health disparities and outcomes
- Urinary Bladder and Prostate Research
- Ectopic Pregnancy Diagnosis and Management
- Sarcoma Diagnosis and Treatment
- Clinical practice guidelines implementation
University Hospital of Bern
2016-2025
University of Bern
2016-2025
Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e. V. - Hans-Knöll-Institut (HKI)
2023-2024
Universidade de São Paulo
2024
Organisation de Coopération et de Développement Economiques
2014-2023
Universitätsklinik für Augenheilkunde
2023
Spitäler Schaffhausen
2023
Ecolab (United States)
2023
Klinik für Frauenheilkunde
2008-2022
The University of Queensland
2021
This study aimed to calculate costs and health-related quality of life women with endometriosis-associated symptoms treated in referral centres. A prospective, multi-centre, questionnaire-based survey measured ambulatory care 12 tertiary centres 10 countries. The enrolled a diagnosis endometriosis at least one centre-specific contact related 2008. main outcome measures were health costs, productivity loss, total quality-adjusted years. Predictors identified using regression analysis. Data...
Abstract Advances in preoperative diagnostics as well surgical techniques for the treatment of endometriosis, especially deep call a classification system, that includes all aspects disease such peritoneal ovarian and secondary adhesions. The widely accepted revised American Society Reproductive Medicine (rASRM) has certain limitations because its incomplete description endometriosis. In contrast, Enzian classification, which been implemented last decade, proved to be most suitable tool...
Sentinel lymph node biopsy (SLNB) is the standard of care for axillary staging patients with early breast cancer (BC), but its necessity can be questioned since surgery examination nodes not performed curative intent.
Vascular endothelial growth factor (VEGF) mediates angiogenic activity in a variety of estrogen target tissues. To determine whether has direct transcriptional effect on VEGF gene expression, we developed model system by transiently transfecting human promoter-luciferase reporter constructs into primary endometrial cells and Ishikawa cells, derived from well-differentiated adenocarcinoma. In epithelial treatment with 17β-estradiol (E 2 ) resulted 3.8-fold increase luciferase activity,...
Endometriosis affects approximately 15% of reproductive aged women and is associated with chronic pelvic pain infertility. However, the molecular mechanisms by which endometriosis impacts fertility are poorly understood. The developmentally regulated, imprinted H19 long noncoding RNA (lncRNA) functions to reduce bioavailability microRNA let-7 acting as a sponge. Here we report that expression significantly decreased in eutopic endometrium compared normal controls. We show increases activity,...
The high recurrence rate and the low overall survival in ovarian cancer suggest that a more specific therapeutic approach addition to conventional treatment is required. Translational clinical research investigating new molecular targets order find an alternative way affect tumor growth minimize overlap of toxicity antiblastic agents. Given its implication many cellular activities including regulation cell growth, motility, survival, proliferation, protein synthesis, autophagy,...
Abstract A variety of methods have been developed to demultiplex pooled samples in a single cell RNA sequencing (scRNA-seq) experiment which either require hashtag barcodes or sample genotypes prior pooling. We introduce scSplit utilizes genetic differences inferred from scRNA-seq data alone samples. also enables mapping clusters original Using simulated, merged, and multi-individual datasets, we show that prediction is highly concordant with demuxlet predictions consistent the known truth...
Recurrence of endometriosis after surgery constitutes a serious challenge. Whether there is an evolution lesion subtypes with each recurrence and whether certain lesions tend to recur faster than others not adequately addressed. Medical records all patients who underwent for between 1997 2018 in the Department Gynecology Obstetrics, University Bern, were reviewed. Inclusion criteria was surgically confirmed recurrence, defined as subsequent previous complete surgical excision lesions. Three...
ObjectiveDespite its generally favorable prognosis at primary diagnosis, recurrence of endometrial cancer remains an important clinical challenge. The aim this study was to analyze the value molecular classification in recurrent cancer.MethodsThis included patients with who underwent surgical treatment between 2004 and 2015 Karolinska University Hospital, Sweden Bern Switzerland (KImBer cohort) tumor.ResultsOut 594 molecularly classified patients, 101 experienced recurrence, consisting 2...
The purpose of this study was to establish a consensus on the surgical technique for sentinel lymph node (SLN) dissection in cervical cancer.
Abstract The efficacy of antitumor immunity is associated with the metabolic state cytotoxic T cells, which sensitive to tumor microenvironment. Whether ionic signals affect adaptive immune responses unclear. In present study, we show that there an enrichment sodium in solid tumors from patients breast cancer. Sodium chloride (NaCl) enhances activation and effector functions human CD8 + enhanced fitness. These NaCl-induced effects translate into increased cell killing vitro vivo....