A5019814409- Endometrial and Cervical Cancer Treatments
- Ovarian cancer diagnosis and treatment
- Endometriosis Research and Treatment
- Uterine Myomas and Treatments
- Cervical Cancer and HPV Research
- Breast Cancer Treatment Studies
- Pelvic floor disorders treatments
- Gynecological conditions and treatments
- Intestinal and Peritoneal Adhesions
- Cancer Genomics and Diagnostics
- Estrogen and related hormone effects
- Cancer-related molecular mechanisms research
- Breast Implant and Reconstruction
- Lymphatic System and Diseases
- Prostate Cancer Treatment and Research
- Pregnancy-related medical research
- Genetic factors in colorectal cancer
- Hernia repair and management
- Radiomics and Machine Learning in Medical Imaging
- Pelvic and Acetabular Injuries
- BRCA gene mutations in cancer
- Colorectal Cancer Screening and Detection
- Reproductive Biology and Fertility
- Genital Health and Disease
- Wnt/β-catenin signaling in development and cancer
University Hospital of Bern
2016-2025
University of Bern
2016-2025
Klinik für Frauenheilkunde
2018
Heidelberg University
2017
Zimmer Biomet (Germany)
2017
Hospital Base
2017
University of Lausanne
2017
University of Milano-Bicocca
2017
Universitäts Frauenklinik
2014-2015
Olgahospital
2013
ObjectiveDespite its generally favorable prognosis at primary diagnosis, recurrence of endometrial cancer remains an important clinical challenge. The aim this study was to analyze the value molecular classification in recurrent cancer.MethodsThis included patients with who underwent surgical treatment between 2004 and 2015 Karolinska University Hospital, Sweden Bern Switzerland (KImBer cohort) tumor.ResultsOut 594 molecularly classified patients, 101 experienced recurrence, consisting 2...
In endometrial cancer (EMCA), indocyanine green (ICG) sentinel lymph node (SLN) mapping has been reported, mainly in conjunction with robotic surgery.We aimed to evaluate detection rates, sensitivity, and false negative (FN) rate of laparoscopic ICG SLN EMCA, differences surgical outcomes between patients subjected biopsy only versus lymphadenectomy.A retrospective analysis EMCA undergoing ± pelvic (PLND) and/or para-aortic lymphadenectomy (PALND) was performed. Detection rates were...
(99)TC combined with blue-dye mapping is considered the best sentinel lymph node (SLN) technique in cervical cancer. Indocyanine green (ICG) near infrared fluorescence imaging has been introduced as a new methodology for SLN mapping. The aim of this study was to compare these two techniques laparoscopic treatment cancer.Medical records patients undergoing cancer either (99)Tc and patent blue dye (Group 1) or ICG 2) from April 2008 until August 2012 were reviewed. Sensitivity, specificity,...
Individualized therapy in endometrial cancer, the most common gynaecologic cancer developed world, focuses on identifying specific molecular subtypes. Mutations exonuclease domain of DNA polymerase epsilon (POLE) gene define one such subtype, which causes an ultra-mutated tumour phenotype. These tumours may have improved progression-free survival and be receptive to therapies. However, clinical phenotype these is unknown. The objective this study was evaluate genetic features POLE-mutated...
In 2021, a joint ESGO/ESTRO/ESP committee updated their evidence-based guidelines for endometrial cancer, recommending new risk grouping incorporating both clinicopathologic and molecular parameters. We applied the compared results to those of prior 2016 system.We classified molecularly cohort 604 women diagnosed with cancer using immunohistochemistry TP53 MMR proteins on tissue microarray, as well Sanger sequencing POLE mutations. These results, combined data, allowed patients be grouped...
Aim of our study was to evaluate the therapeutic effect laser treatment in vulvar lichen sclerosus, mainly reduction existing symptoms as itching, burning and pain. We asked about different outcome by using application doses.We conducted a prospective randomized double-blind dose-controlled trial dysplasia unit specializing disorders. 67patients with active LS were included. confirmed biopsy or validated CSS (clinical scoring system LS). Computer generated randomization resulted two groups,...
ObjectiveThe prognostic significance of positive peritoneal cytology in endometrial cancer has long been debated. In 2009, the Fédération Internationale de Gynécologie et d'Obstétrique (FIGO) removed as a staging criterion from system. However, there is still evidence that may decrease survival among patients with cancer. The aim this study was to determine different molecular subgroups.MethodsThis included who underwent primary surgical treatment between 2004 and 2015 at Bern University...
Background: The advantage of robot-assisted hysterectomy over standard laparoscopy remains controversial. Conventional robots offer limited flexibility to the surgeon. novel, Dexter robotic system™, allows integration and easy switch between laparoscopic interface. Objectives: This study’s objective is evaluate feasibility using for hysterectomies by analyzing surgical data intra- postoperative complication rates. Design: Retrospective study. Methods: Women who underwent surgery system at a...
Abstract The autonomic nerves of the lesser pelvis are particularly prone to iatrogenic lesions due their exposed position during manifold surgical interventions. Nevertheless, cause rectal and urinary incontinence or sexual dysfunctions, for example after cancer resection hysterectomy, remains largely understudied, with regard female pelvic plexuses. This study focused on macroscopic description superior hypogastric plexus, nerves, inferior parasympathetic splanchnic sympathetic fibres....
Endometriosis is a common health problem, affecting 10% of women reproductive age. Laparoscopic surgery proven to relieve pain and improve fertility in with endometriosis. However, identifying peritoneal endometriosis lesions may be difficult due their polymorphic aspects. harbor high degree neovascularization. The visualization tissue perfusion by the additional use near infrared fluorescence imaging indocyanine green (ICG) detection lesions.In single-center, prospective, single-arm pilot...