A5046200684- Endometrial and Cervical Cancer Treatments
- Ovarian cancer diagnosis and treatment
- Uterine Myomas and Treatments
- Cancer Genomics and Diagnostics
- Cervical Cancer and HPV Research
- Endometriosis Research and Treatment
- Genetic factors in colorectal cancer
- Gynecological conditions and treatments
- Prostate Cancer Treatment and Research
- Radiomics and Machine Learning in Medical Imaging
- Colorectal Cancer Screening and Detection
- Colorectal and Anal Carcinomas
- Medical Imaging Techniques and Applications
- Ocular Oncology and Treatments
- Brain Metastases and Treatment
- Radiopharmaceutical Chemistry and Applications
- Gastrointestinal disorders and treatments
- Gastrointestinal Tumor Research and Treatment
- Estrogen and related hormone effects
- Biliary and Gastrointestinal Fistulas
- Glioma Diagnosis and Treatment
- Colorectal Cancer Surgical Treatments
- Angiogenesis and VEGF in Cancer
- Sarcoma Diagnosis and Treatment
Karolinska University Hospital
2017-2022
Karolinska Institutet
2016-2022
Svenska Örtmedicinska Institute
2019
Oulu University Hospital
2017
Lund University
2017
Haukeland University Hospital
2017
Aalborg University Hospital
2017
University of Oslo
2017
Oslo University Hospital
2017
Umeå University
2011
ObjectiveDespite its generally favorable prognosis at primary diagnosis, recurrence of endometrial cancer remains an important clinical challenge. The aim this study was to analyze the value molecular classification in recurrent cancer.MethodsThis included patients with who underwent surgical treatment between 2004 and 2015 Karolinska University Hospital, Sweden Bern Switzerland (KImBer cohort) tumor.ResultsOut 594 molecularly classified patients, 101 experienced recurrence, consisting 2...
Individualized therapy in endometrial cancer, the most common gynaecologic cancer developed world, focuses on identifying specific molecular subtypes. Mutations exonuclease domain of DNA polymerase epsilon (POLE) gene define one such subtype, which causes an ultra-mutated tumour phenotype. These tumours may have improved progression-free survival and be receptive to therapies. However, clinical phenotype these is unknown. The objective this study was evaluate genetic features POLE-mutated...
In 2021, a joint ESGO/ESTRO/ESP committee updated their evidence-based guidelines for endometrial cancer, recommending new risk grouping incorporating both clinicopathologic and molecular parameters. We applied the compared results to those of prior 2016 system.We classified molecularly cohort 604 women diagnosed with cancer using immunohistochemistry TP53 MMR proteins on tissue microarray, as well Sanger sequencing POLE mutations. These results, combined data, allowed patients be grouped...
To evaluate the ability of demographic and sonographic variables Proactive Molecular Risk Classifier for Endometrial cancer (ProMisE) classification to predict preoperatively tumor recurrence or progression in women with endometrial cancer.
Objectives To describe sonographic features of the microcystic elongated and fragmented (MELF) pattern myometrial invasion (MI) using International Endometrial Tumor Analysis (IETA) criteria; to assess effect MELF on preoperative ultrasound evaluation MI; determine relationship more advanced stage (≥ IB) lymph node metastases in women with endometrioid endometrial cancer. Methods/materials We included 850 cancer from prospective IETA 4 study. Ultrasound experts performed all examinations,...
Grading and histologic typing of endometrial cancer in biopsy material has a direct impact on the decision to perform lymphadenectomy and/or omentectomy many centers. Endometrial biopsies are among most common general surgical pathology specimens. Multiple studies have shown that diagnosis suffers from lack reproducibility. Although biomarkers been proposed, none demonstrated improve setting. In this study, 70 with carcinoma were supplemented biomarker panel consisting ER, PR, P53, DNA...
The revised International Federation of Gynecology and Obstetrics (FIGO) grading system is widely accepted as the standard in evaluating endometrial carcinoma on biopsy. Determination tumor cell type [using World Health Organization (WHO) diagnostic criteria] grade (using FIGO) guides surgical approach. Several studies have highlighted discrepancies between biopsy hysterectomy diagnosis. Recently, a binary was proposed, yielding low-risk high-risk assessment but independent (CTI) way. No...
Based on the degree of cellular dysplasia, some authors have classified CRA into those exhibiting slight, moderate or severe dysplasia [15], and others showing low high-grade (LGD HGD, respectively) [16].
ABSTRACT Introduction In 2021, a joint ESGO/ESTRO/ESP committee updated their evidence-based guidelines for endometrial cancer, recommending new risk grouping incorporating both clinicopathologic and molecular parameters. We applied the compared results to those of prior 2016 system. Materials methods classified molecularly cohort 604 women diagnosed with cancer using immunohistochemistry TP53 MMR proteins on tissue microarray, as well Sanger sequencing POLE mutations. These results,...
<h3>Introduction/Background*</h3> In 2021, a joint ESGO/ESTRO/ESP committee updated their evidence-based guidelines for endometrial cancer, recommending new risk grouping incorporating both clinicopathologic and molecular parameters. We applied the compared results to those of prior 2016 system. <h3>Methodology</h3> classified molecularly cohort 604 women diagnosed with cancer using immunohistochemistry TP53 MMR proteins on tissue microarray, as well Sanger sequencing <i>POLE</i> mutations....
The novel molecular endometrial cancer classifier, ProMisE, provides independent prognostic information beyond established clinicopathologic risk factors. aim of this study was to correlate the ProMisE sub groups sonographic findings and preoperative clinical, sonographic, variables recurrence/progression. We prospectively included 340 women with undergoing expert ultrasound (US) assessment according IETA. All underwent hysterectomy were followed-up for at least 26 months. Tumours graded...
To describe sonographic features of the microcystic elongated and fragmented (MELF) pattern myometrial invasion (MI) using International Endometrial Tumor Analysis (IETA) criteria; to assess effect MELF on preoperative ultrasound evaluation MI; determine relationship more advanced stage (≥ IB) lymph node metastases (LNM) in women with endometrioid endometrial cancer (EEC). We included 850 EEC from prospective IETA 4 study. Ultrasound experts performed all examinations, according protocol....
Purpose: The purpose of this study was to evaluate the performance a proposed prognostic molecular classification endometrial cancer in retrospective cohort n=604 patients. A secondary goal compare existing models.Methods: All cases were analysed using 1) sequencing exonuclease domain POLE gene, 2) microsatellite instability by immunohistochemistry, and 3) TP53 mutation, as evaluated immunohistochemistry. Additionally, complete histopathological clinical data available. classified markers...
Abstract Purpose: The purpose of this study was to evaluate the performance a proposed prognostic molecular classification endometrial cancer in retrospective cohort n=604 patients. A secondary goal compare existing models. Methods: All cases were analysed using 1) sequencing exonuclease domain POLE gene, 2) microsatellite instability by immunohistochemistry, and 3) TP53 mutation, as evaluated immunohistochemistry. Additionally, complete histopathological clinical data available. classified...