A5040774437- Endometrial and Cervical Cancer Treatments
- Gynecological conditions and treatments
- Uterine Myomas and Treatments
- Endometriosis Research and Treatment
- Ovarian cancer diagnosis and treatment
- Cervical Cancer and HPV Research
- Reproductive tract infections research
- Economic and Financial Impacts of Cancer
- Neonatal Respiratory Health Research
- Neonatal and fetal brain pathology
- Urinary Tract Infections Management
- Preterm Birth and Chorioamnionitis
- Pregnancy and preeclampsia studies
- Ovarian function and disorders
- Ultrasound Imaging and Elastography
- Urological Disorders and Treatments
- Childhood Cancer Survivors' Quality of Life
- Medication Adherence and Compliance
Vilnius University
2013-2024
Vilnius University Hospital Santariskiu Klinikos
2011-2023
Lund University
2010
Malmö University
2006-2009
ABSTRACT Objective To describe the sonographic features of endometrial cancer in relation to tumor stage, grade and histological type, using International Endometrial Tumor Analysis (IETA) terminology. Methods This was a prospective multicenter study 1714 women with biopsy‐confirmed undergoing standardized transvaginal grayscale Doppler ultrasound examination according IETA protocol, by experienced examiners high‐end equipment. Clinical data were entered into web‐based database. We assessed...
Abstract Objectives To determine which endometrial morphology characteristics as assessed by gray‐scale ultrasound and vessel power Doppler are useful for discriminating between benign malignant endometrium in women with postmenopausal bleeding (PMB) sonographic thickness ≥ 4.5 mm to develop logistic regression models calculate the individual risk of malignancy PMB, mm, good visibility detectable signals endometrium. Methods Of 223 consecutive patients PMB 120 fulfilled our inclusion...
To build mathematical models for evaluating the individual risk of endometrial malignancy in women with postmenopausal bleeding and sonographic thickness ≥ 4.5 mm using clinical data, power Doppler ultrasound findings.Of 729 consecutive patients bleeding, 261 no fluid uterine cavity were included. They underwent transvaginal two-dimensional gray-scale examination endometrium. The image showing most vascularized section through endometrium as assessed by was frozen, outlined percentage area...
Abstract Objectives To determine whether endometrial volume or power Doppler indices as measured by three‐dimensional (3D) ultrasound imaging can discriminate between benign and malignant endometrium, to compare their diagnostic performance with that of thickness measurement using two‐dimensional (2D) examination, add any information volume. Methods Sixty‐two patients postmenopausal bleeding ≥ 4.5 mm underwent transvaginal 2D gray‐scale 3D examination the corpus uteri. The was calculated,...
To compare the performance of ultrasound measurements and subjective assessment (SA) in detecting deep myometrial invasion (MI) cervical stromal (CSI) women with endometrial cancer, overall according to whether they had low- or high-grade disease separately, validate published measurement cut-offs prediction models identify MI, CSI high-risk (Grade-3 endometrioid non-endometrioid cancer and/or MI CSI).The study comprised 1538 patients from International Endometrial Tumor Analysis (IETA)-4...
Abstract Objectives The aims of our study were to compare the interobserver reproducibility two‐dimensional (2D) and three‐dimensional (3D) saline contrast sonohysterography (SCSH) agreement these techniques with hysteroscopy, determine which SCSH findings best discriminate between benign malignant endometrium. Methods Consecutive women postmenopausal bleeding endometrial thickness ≥ 4.5 mm underwent 2D 3D SCSH; results videotaped stored electronically, respectively, for analysis by two...
The aim of this study was to assess if ureaplasmas are associated with pregnancy complications and diseases in newborns. Pregnant women complaints threatening signs preterm delivery were included. A sample, taken from the endocervical canal surface cervical portion, sent local microbiology laboratory for DNA detection seven pathogens: Chlamydia trachomatis, Mycoplasma hominis, genitalium, Ureaplasma parvum, urealyticum, Neisseria gonorrhoeae, Trichomonas vaginalis. Pearson Chi-Square test...
Current clinical practice of assessing neonatal condition is based on evaluation umbilical cord arterial blood pH value rather than lactate. However, evidence shows that lactate direct and more predictive measurement or at least equal importance. This study to assess compare values for predicting short-term outcomes.A retrospective cohort was conducted the tertiary level hospital, were sampling collected according standard procedures. Neonatal morbidity registered if one following conditions...
ABSTRACT Objective To develop a preoperative risk model, using endometrial biopsy results and clinical ultrasound variables, to predict the individual of lymph‐node metastases in women with cancer. Methods A mixed‐effects logistic regression model for prediction was developed 1501 prospectively included cancer undergoing transvaginal examination before surgery, from 16 European centers. Missing data, including missing status, were imputed. Discrimination, calibration utility evaluated...
Background and objectives: An expert’s subjective assessment is still the most reliable evaluation of adnexal pathology, thus raising need for methods less dependent on examiner’s experience. The aim this study was to evaluate performance standardized when applied by examiners with different levels experience suggest suitable method less-experienced gynecologists. Materials methods: This single-center retrospective included 50 cases histologically proven first-time benign or malignant...
Abstract Objectives To validate prospectively five mathematical models published in 2007 for calculating the risk of endometrial malignancy a defined high‐risk group patients with postmenopausal bleeding and sonographic thickness ≥ 4.5 mm. Methods Of 1012 consecutive patients, 379 fulfilled our inclusion criteria, which were same as those original study created (endometrial mm, no fluid uterine cavity, detectable Doppler signals endometrium). A standardized history was taken, clinical...
Abstract Purpose To investigate the association of sonographic features and clinical symptoms adenomyosis. Methods This was a prospective observational study. Only reproductive age women who underwent standardized transvaginal ultrasound examination were included. The diagnosis adenomyosis based on proposed by Morphological Uterus Sonographic Assessment (MUSA) group. Pictorial blood loss assessment chart (PBAC) numerical rating scale (NRS) respectively used for evaluation menstrual bleeding...
Objectives To describe sonographic features of the microcystic elongated and fragmented (MELF) pattern myometrial invasion (MI) using International Endometrial Tumor Analysis (IETA) criteria; to assess effect MELF on preoperative ultrasound evaluation MI; determine relationship more advanced stage (≥ IB) lymph node metastases in women with endometrioid endometrial cancer. Methods/materials We included 850 cancer from prospective IETA 4 study. Ultrasound experts performed all examinations,...
ABSTRACT Purpose To evaluate whether the pain experienced during and after Saline‐contrast sonohysterography (SCSH) differs between premenopausal postmenopausal women. Methods Sonohysterography was performed on 133 consecutive women because of suspected endometrial pathology. Of these, 34 were excluded for following reasons: they had cervical stenosis; did not complete or return a questionnaire; tenaculum dilatators used procedure. All asked to fill out questionnaire characterize their mark...
To describe the sonographic features of endometrial cancer in relation to stage, grade, and histological type using International Endometrial Tumor Analysis (IETA) terminology. Prospective multicentre study on 1714 women with undergoing a standardised transvaginal gray-scale Doppler ultrasound examination by an experienced examiner high-end system. Clinical data were entered into web-based protocol. Sonographic characteristics according IETA compared outcome hysterectomy, i.e. tumour type....
To develop and validate pre- postoperative mathematical models to predict recurrence/progression of endometrial cancer, evaluate if these outperform the ESMO/ESGO/ESTRO prognostic risk groups. All 1538 women in prospective IETA4 cohort who underwent preoperative structured ultrasound examination followed by hysterectomy from 2011 2015, were up until 2019-2020 or time death. The groups (based on myometrial invasion, grade, stage, LVSI) forced into respective model. Based scientific knowledge...
Norint užtikrinti, kad kiaušidžių vėžiu susirgusios pacientės būtų laiku ištirtos ir gydomos, labai svarbu kuo anksčiau įtarti piktybinį susirgimą. Šiam tikslui pasiekti sukurta daugybė gimdos priedų darinių piktybiškumo rizikos vertinimo metodų, kurie remiasi ultragarsinio tyrimo, vėžio žymenų kraujyje koncentracijos, klinikiniais pacienčių duomenimis atskirai įvairiose kombinacijose. Taip siekiama sumažinti sprendimo priklausomybę nuo tyrėjo patirties įvertinti, kuriuo atveju saugu...
To prospectively test the diagnostic performance of five published mathematical models including gray scale and power Doppler ultrasound variables for calculating risk malignancy in women with postmenopausal bleeding (PMPB) sonographic endometrial thickness >4.5 mm. 557 consecutive patients PMPB (ET) mm underwent a standardized transvaginal gray-scale examination by one two experienced sonologists. The was calculated using each models. gold standard histological diagnosis endometrium. Model...
We are pleased that our article1 has raised interest. Our reply to Drs Ahmet Basaran and Mustafa follows. First, one cannot use the 95% CI of areas under receiver–operating characteristics curves (AUCs) determine if AUCs statistically significantly different. Had observations not been paired (they because models were tested on same patients) we could have calculated differences in AUC CIs differences; had included zero, concluded did differ significantly. However, paired, special methods...
In this study, we conducted a comparative analysis of demographic, histopathological, and sonographic characteristics between pre- postmenopausal women diagnosed with endometrial cancer, while also examining anthropometric features in 'low' 'intermediate/high-risk' cases, stratified by menopausal status. Our analysis, based on data from the International Endometrial Tumor Analysis (IETA) 4 cohort comprising 1538 (161 premenopausal, 1377 postmenopausal) biopsy-confirmed revealed that...
To build mathematical models for calculation of the individual risk endometrial malignancy in women with postmenopausal bleeding using clinical data, sonographic thickness and power Doppler results. Two hundred sixty one patients bleeding, > 4.5 mm no fluid uterine cavity were included. They underwent transvaginal two-dimensional gray scale ultrasound examination endometrium. The image showing most vascularised section through endometrium as assessed by was frozen, outlined, percentage area...
To compare the ability of two-dimensional (2D) and three-dimensional (3D) hydrosonography to discriminate between benign malignant endometrium in women with postmenopausal bleeding (PMB) endometrial thickness 4.5 mm more. Of 170 consecutive patients PMB more, 94 underwent 2D 3D followed by hysteroscopic resection focal lesions/endometrium, dilatation curettage or hysterectomy. The scans were videotaped saved electronically for later independent analysis two experienced examiners using a...
To determine the agreement of two-dimensional (2D) and 3D hydrosonography with hysteroscopy regard to presence, number, surface regularity localization focal lesions in uterine cavity women postmenopausal bleeding (PMB) endometrial thickness 4.5 mm or more. Of 170 consecutive patients PMB more, 54 fulfilled our inclusion criteria. They underwent 2D followed by under general anesthesia hysteroscopic resection curettage. The scans were videotaped saved electronically for later independent...
To describe ultrasound features of atypical endometrial hyperplasia in postmenopausal women. Retrospective study. 495 women with vaginal bleeding and endometrium ≥5mm were examined transvaginal gray-scale power Doppler by an experienced examiner. Endometrium was assessed according IETA terms, definitions measurements. Final histological diagnosis gold standard for selecting this particular group patients. Out women, 19 had at final diagnosis. Demographic data those is expressed as median...