A5001536726- Genetic factors in colorectal cancer
- Helicobacter pylori-related gastroenterology studies
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Screening and Detection
- Gastrointestinal disorders and treatments
- Health Systems, Economic Evaluations, Quality of Life
- Inflammatory Bowel Disease
- Microscopic Colitis
- Colorectal Cancer Treatments and Studies
- Glycogen Storage Diseases and Myoclonus
- Neuroscience and Neuropharmacology Research
- Colorectal Cancer Surgical Treatments
- Colorectal and Anal Carcinomas
- Gastrointestinal Tumor Research and Treatment
- Esophageal Cancer Research and Treatment
- Mitochondrial Function and Pathology
- Digestive system and related health
- Metabolism and Genetic Disorders
- Eosinophilic Esophagitis
- Gastroesophageal reflux and treatments
- Drug Transport and Resistance Mechanisms
- Cervical Cancer and HPV Research
- Inflammatory mediators and NSAID effects
- Chronic Lymphocytic Leukemia Research
- Neurotransmitter Receptor Influence on Behavior
Madrid Health Service
2016-2025
Karolinska Institutet
2015-2024
Hospital Universitario La Paz
2006-2024
Universidad de San Buenaventura, Bogota
2023-2024
Comunidad de Madrid
2010-2024
Research Institute Hospital 12 de Octubre
2002-2023
Centro de Investigación Biomédica en Red
2007-2023
Centre for Biomedical Network Research on Rare Diseases
2007-2023
Instituto de Salud Carlos III
2007-2023
Instituto de Investigación de Enfermedades Raras
2012-2023
Increasing our understanding of Earth’s biodiversity and responsibly stewarding its resources are among the most crucial scientific social challenges new millennium. These require fundamental knowledge organization, evolution, functions, interactions millions planet’s organisms. Herein, we present a perspective on Earth BioGenome Project (EBP), moonshot for biology that aims to sequence, catalog, characterize genomes all eukaryotic over period 10 years. The outcomes EBP will inform broad...
Significance The Amazonian tropical forests have been disappearing at a fast rate in the last 50 y due to deforestation open areas for agriculture, posing high risks of irreversible changes biodiversity and ecosystems. Climate change poses additional stability forests. Studies suggest “tipping points” not be transgressed: 4° C global warming or 40% total deforested area. regional development debate has focused on attempting reconcile maximizing conservation with intensification traditional...
Mitochondrial dysfunction might play a central role in the pathogenesis of nonalcoholic steatohepatits (NASH). The aims this study were to evaluate whether free fatty acid (FFA) transport into mitochondria or activity respiratory chain (MRC) complexes are impaired NASH. In patients with NASH and control subjects, we measured carnitine, short–chain acylcarnitine (SCAC) long–chain (LCAC) esters, carnitine palmitoyltransferase (CPT) activity, MRC enzyme liver tissue as well serum concentration...
The histologic examination of endoscopic biopsies or resection specimens remains a key step in the work-up affected inflammatory bowel disease (IBD) patients and can be used for diagnosis differential diagnosis, particularly differentiation UC from CD other non-IBD related colitides. introduction new treatment strategies interfering with patients' immune system may result mucosal healing, making pathologists aware impact upon diagnostic features. European Crohn's Colitis Organisation (ECCO)...
November 2020 marked 2 y since the launch of Earth BioGenome Project (EBP), which aims to sequence all known eukaryotic species in a 10-y timeframe. Since then, significant progress has been made across aspects EBP roadmap, as outlined 2018 article describing project’s goals, strategies, and challenges (1). The phase ended clock started on reaching EBP’s major milestones. This Special Feature explores many facets EBP, including review progress, description scientific exemplar projects,...
The dioxin/aryl hydrocarbon receptor (AhR) functions as a ligand-activated transcription factor regulating of battery genes encoding xenobiotic metabolizing enzymes. Known ligands are environmental pollutants including polycyclic aromatic hydrocarbons and polychlorinated dioxins. Loss-of-function (gene-disruption) studies in mice have demonstrated that the AhR is involved toxic effects dioxins but not yielded unequivocal results concerning physiological function receptor. Gain-of-function...
(1971). Investigation on Tumour Spread in Connection with Aspiration Biopsy. Acta Radiologica: Therapy, Physics, Biology: Vol. 10, No. 4, pp. 385-398.
A novel histologic phenotype of chronic esophagitis, ie, lymphocytic is reported in 20 patients. Lymphocytic esophagitis characterized by high numbers intraepithelial lymphocytes (IELs) gathered mainly around peripapillary fields and none (n = 12) to occasional 8) CD15+ granulocytes. IELs expressed CD3, CD4 (42%), CD8 (36%), granzyme B (0.2%), whereas T-cell intracytoplasmic antigen (TIA) 1 was not expressed. Of the patients, 11 (55%) were 17 years or younger. 5 had no symptoms upper...
<h3>Background</h3> Published genotype/phenotype data on McArdle disease are limited in sample size. A single national (Spanish) registry of patients with was created the purpose analysing their genotypic and phenotypic characteristics. <h3>Methods</h3> cross sectional study conducted, collecting demographic, family history, clinical, genotype functional capacity from all diagnosed Spanish National Health System up to December 2010. <h3>Results</h3> 239 cases were recorded (all Caucasian...
A global international initiative, such as the Earth BioGenome Project (EBP), requires both agreement and coordination on standards to ensure that collective effort generates rapid progress toward its goals. To this end, EBP initiated five technical committees comprising volunteer members from genomics scientific community: Sample Collection Processing, Sequencing Assembly, Annotation, Analysis, IT Informatics. The current versions of resulting documents are available website, with...
Extensive, long-standing inflammatory bowel disease is associated with an increased risk of developing colorectal carcinoma. Low-grade dysplasia has been used as a marker for malignant transformation and by some indication prophylactic colectomy. The aim the present study was to follow up all patients extensive, colitis who had low-grade in flat colonic mucosa.All mucosa found at screening or surveillance colonoscopy least one follow-up colectomy were included.Sixty (40 males; mean age...
Abstract We found a variable defect of complex I the mitochondrial respiratory chain, ranging in severity from 25% to 63% control values, muscle patients with Huntington's disease (HD). The most severe was observed patient greatest expansion CAG triplets. Muscle morphology showed myopathic changes such as moth‐eaten fibers, angulated increased subsarcolemmal oxidative activities, or an number enlarged mitochondria abnormal cristae. Multiple DNA deletions were by polymerase chain reaction...
The cellular DNA pattern in 66 colo-rectal adenocarcinomas was studied by means of flow-cytometric analysis. degree ploidy and the proportion cells S-phase were related to clinical stage according Dukes' classification histological differentiation. Multiple cell populations found about 60 per cent tumours but more frequently advanced stages. According index bimodally distributed with one peak diploid-peridiploid region tri- tetraploid region. In second group there a higher frequency as...
Abstract We present a generic spatially explicit modeling framework to estimate carbon emissions from deforestation ( INPE ‐ EM ). The incorporates the temporal dynamics related process and accounts for biophysical socioeconomic heterogeneity of region under study. build an emission model Brazilian Amazon combining annual maps new clearings, four biomass, set alternative parameters based on recent literature. most important results are as follows: (a) Using different biomass leads large...