Anne Jouret‐Mourin
A5051482130- Colorectal Cancer Surgical Treatments
- Colorectal Cancer Treatments and Studies
- Cancer Immunotherapy and Biomarkers
- Colorectal and Anal Carcinomas
- Colorectal Cancer Screening and Detection
- Inflammatory Bowel Disease
- Microscopic Colitis
- Pancreatic and Hepatic Oncology Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Gastric Cancer Management and Outcomes
- Autoimmune and Inflammatory Disorders
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Eosinophilic Esophagitis
- Helicobacter pylori-related gastroenterology studies
- Esophageal and GI Pathology
- Genetic factors in colorectal cancer
- Cancer Genomics and Diagnostics
- Neuroendocrine Tumor Research Advances
- Gastrointestinal disorders and treatments
- Lymphatic System and Diseases
- Liver Diseases and Immunity
- Medical Imaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Lymphatic Disorders and Treatments
- Clinical practice guidelines implementation
Cliniques Universitaires Saint-Luc
2013-2023
UCLouvain
2009-2023
Institute of Pathology and Genetics
2022-2023
Leefmilieu Brussel
2018
Hôpital Civil de Charleroi
1986
This study assesses how the metastatic immune landscape is impacting response to treatment and outcome of colorectal cancer (CRC) patients. Complete curative resection metastases (n = 441) was performed for two patient cohorts 153). Immune densities were quantified in center invasive margin all metastases. Immunoscore T B cell (TB) score analyzed relation radiological pathological responses patient’s disease-free (DFS) overall survival (OS) using multivariable Cox proportional hazards...
The purpose of this study was to evaluate the prognostic value Immunoscore in patients with stage III colon cancer (CC) and analyze its association effect chemotherapy on time recurrence (TTR).
Objectives Assessment of proliferation by the Ki‐67 labelling index ( K i67‐ LI ) is an important parameter pancreatic neuroendocrine tumour pNET prognosis on resection specimens. values for grading are not fully established endoscopic ultrasound‐guided fine needle aspiration EUS ‐ FNA ). The aim study was to determine accuracy predict a final grade p NET and analyse relationship between cytological progression‐free survival PFS Methods Between 1996 2010, 46 pNETs (33 were resected) from 45...
Abstract Purpose: No biomarker to personalize treatment in locally advanced rectal cancer (LARC) is currently available. We assessed LARC whether a diagnostic biopsy-adapted immunoscore (ISB) could predict response neoadjuvant (nT) and better define patients eligible an organ preservation strategy (“Watch-and-Wait”). Experimental Design: Biopsies from two independent cohorts (n1 = 131, n2 118) of with treated nT followed by radical surgery were immunostained for CD3+ CD8+ T cells quantified...
Involvement of the lymphatic system in inflammatory bowel disease (IBD) has been suggested.To examine density and distribution vessels (LV) within inflamed non-inflamed wall sections IBD patients compared with controls, to evaluate expression major lymphangiogenic factors.Ileal colon specimens 22 Crohn's (CD), 16 ulcerative colitis (UC) 11 controls were studied. Quantification LV was performed using immunohistochemistry podoplanin D2-40 antibodies on seven randomly selected fields. Mucosal...
Background: The prognostic value of Immunoscore was evaluated in Stage II/III colon cancer (CC) patients, but it remains unclear I/II, and early-stage subgroups at risk. An international Society for Immunotherapy Cancer (SITC) study the pre-defined consensus tumors from 1885 AJCC/UICC-TNM I/II CC patients Canada/USA (Cohort 1) Europe/Asia 2). METHODS: Digital-pathology is used to quantify densities CD3+ CD8+ T-lymphocyte center tumor (CT) invasive margin (IM). time recurrence (TTR) primary...
To determine preoperative tumor-, patient-, and treatment-related factors that are independently associated with incomplete mesorectal excision.Incomplete total excision (TME) for rectal cancer is increased local overall recurrences. Factors predicting have scarcely been studied.In the context of PROCARE, a Belgian multidisciplinary project on cancer, quality 266 consecutive anonymized TME specimens submitted by 33 candidate-TME-trainers was graded blinded pathology review board in...
Since the WHO Classification of Tumours Digestive System has been published in 2010, resected pancreatic neuroendocrine tumours (pNETs) are graded as grade 1 (G1), 2 (G2) or 3 (G3) using Ki67 labelling index (Ki67-LI). Endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) is often used for diagnosis, but few studies have assessed its value grading.The aims this study were to compare Ki67-LI obtained by cytological grading (cG) with that histological (hG) and assess (1) influence...
Increased lymphatic vessel (LV) density has been found in uninflamed intestinal wall of patients with Crohn's disease (CD). The goal the study was to search for an association between LV proximal ileal resection margin at time surgery and endoscopic recurrence.Ileocolonic specimens were obtained from 28 CD 10 control subjects. section used histological quantification using immunohistochemistry D2-40 antibody mucosa submucosa. Quantification performed 8 consecutive fields blinded recurrence...
Abstract Background Research on the relationship between hospital volume and quality of care in treatment rectal cancer is limited. Methods Process outcome indicators were assessed patients with adenocarcinoma who underwent total mesorectal excision, registered a voluntary basis PROCARE clinical database. Volume was derived from an administrative database analysed as continuous variable. Sphincter preservation, 30-day mortality survival rates cross-checked against population-based data....
Nodal stage is a strong prognostic factor of oncological outcome rectal cancer. To compensate for the variation in total number harvested nodes, calculation lymph node ratio (LNR) has been advocated. The aim study was to compare impact, on long-term outcome, LNR with other predictive factors, including quality mesorectal excision (TME) and state circumferential resection margin.Consecutive patients having elective surgery nonmetastatic cancer were extracted from prospectively maintained...
Abstract Surgical resection of colorectal liver metastases combined with systemic treatment aims to maximize patient survival. However, recurrence rates are very high postsurgery. In order assess prognosis after metastasis resection, we evaluated the main patho‐molecular and immune parameters all surgical specimens. Two hundred twenty‐one patients who underwent, different preoperative treatment, curative 582 were analyzed. Clinicopathological parameters, RAS tumor mutation, consensus...
Background The feasibility and outcome of endoscopic resection in ampullary tumors with intraductal growth remains unclear. Objective To assess the safety, outcomes these patients treated by thermal ablation. Methods Retrospective observational study. All consecutive who underwent an snare papillectomy a 6‐month minimum follow‐up were included. Ablation was performed cystotomes soft/forced coagulation. Successful treatment defined as no adenomatous residual tissue or recurrence observed at...
Light has been shed on the genotype/phenotype correlation in hepatocellular adenoma (HCA) recognizing HNF1 α -inactivated HCA (H-HCA), inflammatory (IHCA), and β -catenin-activated (b-HCA). We reviewed retrospectively our surgical series to learn how recognize different subtypes histopathologically interpret adequately their immunohistochemical staining. From January 1992 2012, 37 patients underwent resection for institution. Nine had H-HCA (25%) characterized by steatosis loss of L-FABP...
BACKGROUND: In this study, we evaluated the prognostic value of Immunoscore in patients with stage I−III colon cancer (CC) Asian population. These were originally included an international study led by Society for Immunotherapy Cancer (SITC) on 2681 AJCC/UICC-TNM stages CC. METHODS: CD3+ and cytotoxic CD8+ T-lymphocyte densities quantified tumor invasive margin digital pathology. The association prognosis was time to recurrence (TTR), disease-free survival (DFS), overall (OS). RESULTS:...
Abstract Aim Data on quality control of the pathologic evaluation total mesorectal excision ( TME ) specimens are scarce. We aimed to assess differences between by local pathologists participating in PRO ject CA ncer RE ctum PROCARE ; a Belgian improvement project rectal cancer) and review panel experts. Method Based photographic material histopathology slides, Review Committee gastrointestinal expert re‐evaluated plane, tumour differentiation grade, (y) pT stage regression grade 444...
Optimal preoperative treatment before colorectal cancer metastases (CRCM) resection remains unclear. This study evaluated pathological responses (pR) in CRCM resected after chemotherapy alone or combined with angiogenesis epidermal growth factor receptor (EGFR) inhibitors.Pathological response was retrospectively on 264 from 99 patients. The proportion of responding different treatments reported and compared. Patient's progression-free survival (PFS) overall (OS) were compared based pR.The...
Background The progress of modern imaging studies has improved the diagnostic approach benign liver tumours, leading to a tailored with increased conservative management. Methods One hundred and thirty-two patients suffering from hepatic tumours were enrolled in this study, including an operative (group I, 49 patients) II, 83 Patients' tumour treatment features analyzed. Results mean patients' age was 39 years. Indication for resection based on diagnosis nature (hepatic cell adenoma or...