A5075875304- Genomics and Phylogenetic Studies
- Gut microbiota and health
- Genetic diversity and population structure
- Livestock and Poultry Management
- Chromosomal and Genetic Variations
- Bird parasitology and diseases
- Insect-Plant Interactions and Control
- Diet and metabolism studies
- Polysaccharides and Plant Cell Walls
- Animal Nutrition and Physiology
- Fungal Biology and Applications
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Olfactory and Sensory Function Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroendocrine regulation and behavior
- Pharmaceutical and Antibiotic Environmental Impacts
- Neuroscience and Neuropharmacology Research
- Identification and Quantification in Food
- Environmental Toxicology and Ecotoxicology
- Effects and risks of endocrine disrupting chemicals
- Neuroscience and Neural Engineering
- Microbial Natural Products and Biosynthesis
- Stress Responses and Cortisol
- Probiotics and Fermented Foods
- Neurological disorders and treatments
Soochow University
2025
First Affiliated Hospital of Soochow University
2025
Taishan University
2023-2024
BGI Group (China)
2019-2024
Gansu University of Traditional Chinese Medicine
2024
Gansu Provincial Hospital
2024
BGI Research
2024
Tianjin First Center Hospital
2024
Tianjin Medical University
2024
Southwest Medical University
2021-2023
Abstract New genome assemblies have been arriving at a rapidly increasing pace, thanks to decreases in sequencing costs and improvements third-generation technologies 1–3 . For example, the number of vertebrate currently NCBI (National Center for Biotechnology Information) database 4 increased by more than 50% 1,485 year from July 2018 2019. In addition this influx different species, new human de novo 5 are being produced, which enable analysis not only small polymorphisms, but also complex,...
Human-induced environmental change and habitat fragmentation pose major threats to biodiversity require active conservation efforts mitigate their consequences. Genetic rescue through translocation the introduction of variation into imperiled populations has been argued as a powerful means preserve, or even increase, genetic diversity evolutionary potential endangered species [1Weeks A.R. Sgro C.M. Young A.G. Frankham R. Mitchell N.J. Miller K.A. Byrne M. Coates D.J. Eldridge M.D. Sunnucks...
Abstract Despite tremendous efforts in the past decades, relationships among main avian lineages remain heavily debated without a clear resolution. Discrepancies have been attributed to diversity of species sampled, phylogenetic method and choice genomic regions 1–3 . Here we address these issues by analysing genomes 363 bird 4 (218 taxonomic families, 92% total). Using intergenic coalescent methods, present well-supported tree but also marked degree discordance. The confirms that Neoaves...
Genomes are typically mosaics of regions with different evolutionary histories. When speciation events closely spaced in time, recombination makes the sharing same history small, and changes rapidly as we move along genome. examining rapid radiations such early diversification Neoaves 66 Mya, no consistent is observed across segments exceeding kilobases Here, report an exception. We found that a 21-Mb region avian genomes, mapped to chicken chromosome 4, shows extremely strong...
Titanium dioxide nanoparticles (n-TiO2) and bisphenol A (BPA) are widespread environmental contaminants in the aquatic environment. We hypothesized that n-TiO2 may adsorb BPA, thus modify its bioavailability toxicity to organisms. In this study, of BPA (0, 2, 20, 200 μg/L) was investigated presence (100 μg/L). The sorbed resulting were taken up by zebrafish, where they translocated liver, brain, gonad tissues. Increased tissue burdens both observed following coexposure, also caused a...
A global international initiative, such as the Earth BioGenome Project (EBP), requires both agreement and coordination on standards to ensure that collective effort generates rapid progress toward its goals. To this end, EBP initiated five technical committees comprising volunteer members from genomics scientific community: Sample Collection Processing, Sequencing Assembly, Annotation, Analysis, IT Informatics. The current versions of resulting documents are available website, with...
Abstract Unlike microevolutionary processes, little is known about the genetic basis of macroevolutionary processes. One these magnificent examples transition from non-avian dinosaurs to birds that has created numerous evolutionary innovations such as self-powered flight and its associated wings with feathers. By analysing 48 bird genomes, we identified millions avian-specific highly conserved elements (ASHCEs) predominantly (>99%) reside in non-coding regions. Many ASHCEs show...
Polysaccharides from the rhizome of Polygonatum sibiricum display a variety biological activities, including regulation intestinal microbiota, but polysaccharides leaves P. have not been studied extensively. Here, we extracted crude and further separated purified them to study effects (PsPs) on microbes short-chain fatty acids (SCFAs). The PsPs had total sugar content 97.48% monosaccharide composition comprising mannose, rhamnose, galacturonic acid, glucose, xylose, arabinose, with molar...
Abstract Penguins lost the ability to fly more than 60 million years ago, subsequently evolving a hyper-specialized marine body plan. Within framework of genome-scale, fossil-inclusive phylogeny, we identify key geological events that shaped penguin diversification and genomic signatures consistent with widespread refugia/recolonization during major climate oscillations. We further suite genes potentially underpinning adaptations related thermoregulation, oxygenation, diving, vision, diet,...
The network oscillation and synaptic plasticity are known to be regulated by GABAergic inhibition, but how they affected changes in the GABA transporter activity remains unclear. Here we show that CA1 region of mouse hippocampus, pharmacological blockade or genetic deletion transporter-1 (GAT1) specifically impaired long-term potentiation (LTP) induced theta burst stimulation, had no effect on LTP high-frequency stimulation depression low-frequency stimulation. extent impairment depended...
Controlling antibiotic resistance genes (ARGs) is a worldwide intervention to ensure global health. Hospital wastewater the main pollution source of antibiotic-resistant bacteria and ARGs in environment. Expanding our knowledge on bacterial composition hospital could help us control infections hospitals decrease pathogen release into In this study, high-throughput sequencing-based metagenomic approach was applied investigate community untreated from three different types [the general...
Abstract Cactus, a reference-free multiple genome alignment program, has been shown to be highly accurate, but the existing implementation scales poorly with increasing numbers of genomes, and struggles in regions duplicated sequence. We describe progressive extensions Cactus that enable tens thousands large vertebrate genomes while maintaining high quality. show is capable scaling hundreds beyond by describing results from an over 600 amniote which our knowledge largest yet created....
Post-operative delirium (POD) is a serious complication which occurs after surgery, especially in the elderly undergoing abdominal surgery. Increasing evidence has revealed an association between gut microbiota and psychological disorders involving "brain-gut" axis. However, pathogenesis of POD surgery aging composition remains unclear.Forty patients (≥65 years old) who underwent were included study. Twenty had POD, whereas 20 did not. was diagnosed assessed using confusion assessment method...
Antibiotics are very effective in treating a variety of bacterial infections, while clinical overuse antibiotics can lead to diseases such as antibiotic-associated diarrhea. Numerous studies have shown that natural polysaccharides be used prebiotics alleviate diarrhea (AAD). Poria cocos is medicinal and edible mushroom widely for thousands years China, our former study demonstrated water-insoluble polysaccharide (PCY) has the potential prebiotic function. Therefore, we simulated digestion...
Make the switch: The three-enzyme cassette MarG/H/I is responsible for stereospecific biosynthesis of β-methyltryptophan from L-tryptophan (1). MarG/I convert 1 into (2S,3R)-β-methyltryptophan, while combined with MarH (2S,3S)-β-methyltryptophan. serves as a stereochemical switch by catalyzing stereoinversion β-stereocenter.