A5067595969- Mesenchymal stem cell research
- Gastrointestinal motility and disorders
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Extracellular vesicles in disease
- Birth, Development, and Health
- Growth Hormone and Insulin-like Growth Factors
- Plant Molecular Biology Research
- Plant Gene Expression Analysis
- Fish Ecology and Management Studies
- Primate Behavior and Ecology
- Neuroinflammation and Neurodegeneration Mechanisms
- Turtle Biology and Conservation
- Neuroscience and Music Perception
- Music Therapy and Health
- Animal Behavior and Reproduction
- Cardiac Fibrosis and Remodeling
- Plant Reproductive Biology
- Chromosomal and Genetic Variations
- Histiocytic Disorders and Treatments
- Cardiac and Coronary Surgery Techniques
- Viral Infections and Immunology Research
- Hepatitis Viruses Studies and Epidemiology
- Microbial Metabolism and Applications
- interferon and immune responses
- Antioxidant Activity and Oxidative Stress
First Teaching Hospital of Tianjin University of Traditional Chinese Medicine
2019-2025
Zhejiang University
2013-2023
Northwest University
2023
Fruit Research Institute
2014-2022
Sir Run Run Shaw Hospital
2013-2022
Blood Center of Zhejiang Province
2022
Army Medical University
2021
Southwest Hospital
2021
Zhejiang Museum of Natural History
2019-2020
Xuan Wu Hospital of the Capital Medical University
1996-2019
Comparative analysis of primate genomes within a phylogenetic context is essential for understanding the evolution human genetic architecture and diversity. We present such study 50 species spanning 38 genera 14 families, including 27 first reported here, with many from previously less well represented groups, New World monkeys Strepsirrhini. Our analyses reveal heterogeneous rates genomic rearrangement gene across lineages. Thousands genes under positive selection in different lineages play...
A chromosome-level giraffe genome assembly and gene-edited mice reveal molecular mechanisms underpinning its high stature.
A critical-sized bone defect, which cannot be repaired through self-healing, is a major challenge in clinical therapeutics. The combination of biomimetic hydrogels and nano-hydroxyapatite (nano-HAP) promising way to solve this problem by constructing an osteogenic microenvironment. However, it challenging generate nano-HAP with similar morphology structure that natural bone, limits the improvement regeneration hydrogels. Inspired our previous works on organic-inorganic cocross-linking, here,...
Morella rubra, red bayberry, is an economically important fruit tree in south China. Here, we assembled the first high-quality genome for both a female and male individual of bayberry. The size was 313-Mb, 90% sequences were into eight pseudo chromosome molecules, with 32 493 predicted genes. By whole-genome comparison between association analysis bulked DNA samples from male, 59-Kb region determining identified located on distal end pseudochromosome 8, which contains abundant transposable...
The biological mechanisms that underpin primate social evolution remain poorly understood. Asian colobines display a range of organizations, which makes them good models for investigating evolution. By integrating ecological, geological, fossil, behavioral, and genomic analyses, we found colobine primates inhabit colder environments tend to live in larger, more complex groups. Specifically, glacial periods during the past 6 million years promoted selection genes involved cold-related energy...
MicroRNA (miR)‑146a levels are reduced in peripheral blood mononuclear cells of patients with systemic lupus erythematosus (SLE); however, its function is not well understood. The present study investigated the role miR‑146a regulation lipopolysaccharide (LPS)‑induced inflammation THP‑1 cells. A mimic and an inhibitor were used to overexpress downregulate expression, respectively. Reverse transcription‑quantitative PCR western blot analyses performed evaluate interleukin (IL)‑1...
Dilated cardiomyopathy (DCM), the most prevalent form of primary heart muscle disease, is third common cause failure and frequent reason for cardiac transplantation. Mounting evidence has demonstrated that genetic risk factors are crucial in pathogenesis DCM. However, DCM genetically heterogeneous, basis a large majority cases remains unclear. In current study, coding exons flanking introns GATA6 gene, which encodes zinc‑finger transcription factor essential cardiogenesis, was sequenced 140...
Peripheral nerve injury (PNI) is a common disease that difficult to regeneration with current therapies. Fortunately, Zou et al demonstrated the role and mechanism of bone marrow derived mesenchymal stem cells (BMSCs) in promoting regeneration, revealing broad prospects for BMSCs transplantation alleviating PNI. We confirmed fact significantly alleviate PNI, but there are shortcomings such as low cell survival rate immune rejection, which limit wide application BMSCs. BMSCs-derived exosomes...
Haemorrhagic fever with renal syndrome (HFRS) is a fatal disease caused by Hantaan virus (HTNV) infection. Humoral immunity essential for effective viral clearance, but the glycosylation characteristics of immunoglobulin G (IgG) in HFRS patients not well known. Peripheral blood mononuclear cells from were obtained B subset analysis using scRNA-seq and flow cytometry. HTNV specific IgG antibody titers detected enzyme linked immunosorbent assay, was analyzed ultra-performance liquid...
Abstract The effects of bone marrow cell transplantation (BMT) on myocardial infarct might be affected by host intrinsic circumferences. A best vascular niche was shown in the infarcted hearts with collateral vessels at 2 weeks after infarction (MI). BMT caused greatest cardiac repairs MI swine better vessels, which relative to richer greater vessel densities, and higher expressions basif fibroblast growth factor stromal cell–derived factor-1 before BMT. Our data suggest that existence...
The broad goal of physiological genomics research is to link genes their functions using appropriate experimental and computational techniques. Modern experiments enable the generation vast quantities data, interpretation this data requires integration information derived from many diverse sources. Computational biology bioinformatics offer ability manage channel torrent. Rat Genome Database (RGD; http://rgd.mcw.edu) has developed tools strategies specifically supporting linking functional...
The emotional state, psychological characteristics, cognitive function, and the relevance among above factors in patients with functional constipation (FC) are complex. This study aimed to investigate whether FC symptoms might be related implicit processing such as characteristics somatization. Thirty-five 24 normal volunteers were recruited collect event-related potentials (ERP) behavior electroencephalogram data when simple digital GoNogo visual tasks performed. Hamilton Depression Scale...
Red bayberry is a sweet, tart fruit native to China and grown widely in the south. The key organic compounds forming distinctive aroma red bayberry, are terpenoids, mainly β-caryophyllene α-pinene. However, genes responsible for different terpenoids still unknown. Here, transcriptome analysis on samples from four cultivars, during development, with terpenoid production, provided candidate volatile compound (VOC) production. Terpene synthases (TPS) enzymes regulating biosynthesis, 34 TPS...
The molecular mechanism of sex development and differentiation in the economically important dioecious fruit tree, red bayberry (Morella rubra), was revealed using next-generation transcriptome sequencing (NGS), comparative analyses were used to identify differentially expressed genes (DEGs) female male flower buds. A total 7029 these DEGs identified at two early stages. KEGG pathway enrichment analysis that plant hormone signal transduction significantly overrepresented, 91 related hormones...
Abstract The Chinese alligator Alligator sinensis is one of the most endangered crocodilian species, and typically exhibits temperature-dependent sex determination. It extremely important to clarify structure alligators implement recovery projects successfully. However, ratio wild remains unknown. In this study, we collected 28 years data from residing in natural artificial habitats Changxing Nature Reserve, China, examined differences dynamics between these two populations. We observed that...
A novel aspartokinase mutant M372I/T379W from Corynebacterium pekinense was constructed by using site-directed mutagenesis. The enzyme then purified, characterized, and its molecular mechanism comprehensively analyzed. Compared with wild-type AK, the catalytic activity of AK 16.51 fold higher optimum temperature increased 28 to 35 °C. thermostability significantly improved. Microscale thermophoresis analysis indicated that not only weakened inhibitory effect Lys, but also had stronger...
Follicular dendritic cell sarcoma is a very rare bladder tumor with few cases that have been reported in the English literature. We report an unusual case of follicular coexistent urothelial carcinoma (UC) urinary 73-year-old man, who first presented lower abdominal pain. Microscopic examination transurethral resection (TURBT) sample showed neoplasm containing spindle or ovoid-shaped cells were arranged storiform, nested swirling patterns. Abundant mitotic Figs. (30 mitoses/10 high-power...