A5100732502- Spine and Intervertebral Disc Pathology
- Management of metastatic bone disease
- Spinal Fractures and Fixation Techniques
- Electrohydrodynamics and Fluid Dynamics
- Sarcoma Diagnosis and Treatment
- Membrane Separation Technologies
- Bone Tumor Diagnosis and Treatments
- Plant Reproductive Biology
- Chromosomal and Genetic Variations
- Plant Molecular Biology Research
- RNA Research and Splicing
- Cancer Treatment and Pharmacology
- Microbial Natural Products and Biosynthesis
- Plant Gene Expression Analysis
- Cervical and Thoracic Myelopathy
- Genomics and Chromatin Dynamics
- Genetic Mapping and Diversity in Plants and Animals
- Genomics and Phylogenetic Studies
- Membrane-based Ion Separation Techniques
- GABA and Rice Research
- Plasma Applications and Diagnostics
- Anatomy and Medical Technology
- Pickering emulsions and particle stabilization
- Cancer-related molecular mechanisms research
- Congenital heart defects research
Peking University
2013-2025
Peking University Third Hospital
2015-2025
Northwestern Polytechnical University
2021-2025
Qingdao Agricultural University
2019-2024
South China Agricultural University
2022-2024
Guilin Medical University
2023
Wuhan University of Technology
2022
Spinal Research
2022
Sichuan University
2020-2022
Ministry of Education of the People's Republic of China
2022
Study Design. Case report. Objective: To describe a three-dimensional (3D) printed axial vertebral body used in upper cervical spine reconstruction after C2 Ewing sarcoma resection an adolescent boy. Summary of Background Data. is malignant musculoskeletal neoplasm with peak incidence adolescents. Cervical as the primary site tumor has been related to worse prognosis. Tumor particularly challenging atlantoaxial region due complexity anatomy, necessity for extensive according oncological...
Taxus, commonly known as yew, is a well-known gymnosperm with great ornamental and medicinal value. In this study, by assembling chromosome-level genome of the Himalayan yew (Taxus wallichiana) 10.9 Gb in 12 chromosomes, we revealed that tandem duplication acts driving force gene family evolution genome, resulting main genes for paclitaxel biosynthesis, i.e. those encoding taxadiene synthase, P450s, transferases, being clustered on same chromosome. The may also provide genetic resources...
A chromosome-level giraffe genome assembly and gene-edited mice reveal molecular mechanisms underpinning its high stature.
Meiosis is crucial in reproduction of plants and ensuring genetic diversity. Although several genes involved homologous recombination DNA repair have been reported, their functions rice (Oryza sativa) male meiosis remain poorly understood. Here, we isolated characterized the OsFIGNL1 (OsFidgetin-like 1) gene, encoding a conserved AAA-ATPase, explored its function importance pollen formation. The Osfignl1 mutant exhibited normal vegetative growth, but failed to produce seeds displayed...
Abstract Muntjac deer have experienced drastic karyotype changes during their speciation, making it an ideal model for studying mechanisms and functional consequences of mammalian chromosome evolution. Here we generated chromosome-level genomes Hydropotes inermis (2n = 70), Muntiacus reevesi 46), female male M. crinifrons 8/9) a contig-level genome gongshanensis 8/9). These high-quality combined with Hi-C data allowed us to reveal the evolution 3D chromatin architectures We find that fusion...
Reconstruction following resection of the primary tumors upper cervical spine is challenging, and conventional internal implants develop complications in this region. 3D printing, also known as additive manufacturing, can produce patient-specific porous a particular shape for bone defect reconstruction. This study aimed to describe clinical outcomes reconstruction using customized 3D-printed vertebral body 9 patients with involving C2.Patients C2 who were treated our institution between July...
Zanthoxylum bungeanum is an important spice and medicinal plant that unique for its accumulation of abundant secondary metabolites, which create a characteristic aroma tingling sensation in the mouth. Owing to high proportion repetitive sequences, heterozygosity, increased chromosome number Z. bungeanum, assembly chromosomal pseudomolecules extremely challenging. Here, we present genome sequence with dramatically expanded size 4.23 Gb, assembled into 68 chromosomes. This approximately...
Abstract Bioluminescence in beetles has long fascinated biologists, with diverse applications biotechnology. To date, however, our understanding of its evolutionary origin and functional variation mechanisms remains poor. address these questions, we obtained high-quality reference genomes luminous nonluminous 6 Elateroidea families. We then reconstructed a robust phylogenetic relationship for all families related Comparative genomic analyses biochemical experiments suggested that gene...
Rice is a pivotal cereal crop that provides the staple food for more than half of world's population. Along with improvements in standard living, people not only pay attention to grain yield but also quality. Chalkiness one most important index In this study, qPGWC-1, QTL controlling percentage grains chalkiness, was mapped an interval physical distance about 139Kb on chromosome 1 by residual heterozygous line method. qPGWC-1 incomplete dominant and additive effect plays major role...
A 3D-printed vertebral prosthesis can be used to reconstruct a bone defect more precisely because of its tailored shape, with innermost porous structure inducing ingrowth. The aim this study was evaluate the clinical outcomes using artificial body for spinal reconstruction after en bloc resection thoracolumbar tumors.
Bacterial infections pose a significant risk to human health. Magnolol, derived from Magnolia officinalis, exhibits potent antibacterial properties. Synthetic biology offers promising approach manufacture such natural compounds. However, the plant-based biosynthesis of magnolol remains obscure, and lack identification critical genes hampers its synthetic production. In this study, we have proposed one-step conversion chavicol using laccase. After leveraging 20 transcriptomes diverse parts M....
Retrospective Cohort Study. Chondrosarcoma of mobile spine is a rare aggressive malignant tumor and postsurgical local recurrence rates remain high. En bloc resection currently the preferred treatment. Resection that achieves tumor-free margin removal may enable more complete tissue but significantly increases complexity risk surgery results in postoperative complications. We sought to compare surgical outcomes, complications, prognoses between patients who underwent en with without...
Abstract Background Taxus wallichiana is an important species for paclitaxel production. Previous genome versions spp. have been limited by extensive gaps, hindering the complete annotation and mining of (known as Taxol commercially) synthesis pathway-related genes. Results Here, we present first phased high-quality reference T. wallichiana, which significantly improves assembly quality corrects large-scale errors in previous versions. The 2 haplotypes are 9.87 Gb 9.98 length, respectively,...
This was a prospective randomized cohort study aiming at examining the safety and efficacy of artificial vertebral body (AVB) fabricated by electron beam melting (EBM) in comparison to conventional titanium mesh cage (TMC) used single-level anterior cervical corpectomy fusion (SL-ACCF).Forty patients with spondylotic myelopathy (CSM) underwent SL-ACCF using either EBM-AVB or TMC. Patients were evaluated for their demographics, radiological characteristics, neurologic function [using Japanese...
Forward osmosis (FO) technology has a broad application prospect in the field of liquid food concentration because complete retention flavor components and bioactive substances. Membrane fouling is main obstacle affecting FO performance efficiency. This work systematically investigated membrane behavior process for fruit juice elucidated by models resistance-in-series, xDLVO theory FTIR analysis. The results show that AL-FS mode was more suitable concentrating orange juice. Increasing...