A5100362827- Neuroinflammation and Neurodegeneration Mechanisms
- Barrier Structure and Function Studies
- Neurological Disease Mechanisms and Treatments
- Cancer, Stress, Anesthesia, and Immune Response
- Anesthesia and Neurotoxicity Research
- Cancer-related molecular mechanisms research
- Eicosanoids and Hypertension Pharmacology
- Cancer, Hypoxia, and Metabolism
- Immune cells in cancer
- S100 Proteins and Annexins
- Advanced Battery Materials and Technologies
- Nanoplatforms for cancer theranostics
- Biosensors and Analytical Detection
- Advancements in Battery Materials
- Neuropeptides and Animal Physiology
- Tryptophan and brain disorders
- Immune Response and Inflammation
- Nitric Oxide and Endothelin Effects
- Anesthesia and Pain Management
- Genetic diversity and population structure
- Heat shock proteins research
- Luminescence and Fluorescent Materials
- Nerve injury and regeneration
- Advanced Sensor and Energy Harvesting Materials
- Monoclonal and Polyclonal Antibodies Research
Fudan University
2009-2025
Collaborative Innovation Center of Chemistry for Energy Materials
2022-2025
Tianjin University
2025
State Key Laboratory of Food Science and Technology
2024
Nanchang University
2024
Beijing University of Chemical Technology
2022-2024
BGI Group (China)
2021-2023
Ruijin Hospital
2023
Shanghai Jiao Tong University
2021-2023
University of Rochester
2023
Comparative analysis of primate genomes within a phylogenetic context is essential for understanding the evolution human genetic architecture and diversity. We present such study 50 species spanning 38 genera 14 families, including 27 first reported here, with many from previously less well represented groups, New World monkeys Strepsirrhini. Our analyses reveal heterogeneous rates genomic rearrangement gene across lineages. Thousands genes under positive selection in different lineages play...
Sodium-ion batteries (SIBs), as one of the potential candidates for grid-scale energy storage systems, are required to tackle extreme weather conditions. However, all-weather SIBs with a wide operation-temperature range rarely reported. Herein, we propose wide-temperature SIB, which involves carbon-coated Na4 Fe3 (PO4 )2 P2 O7 (NFPP@C) cathode, bismuth (Bi) anode, and diglyme-based electrolyte. We demonstrate that solvated Na+ can be directly stored by Bi anode via an alloying reaction...
Advancements in the development of fast-charging and long-lasting microstructured alloying anodes with high volumetric capacities are essential for enhancing operational efficiency sodium-ion batteries (SIBs). These anodes, however, face challenges such as declined cyclability rate capability, primarily due to mechanical degradation reduced by significant changes (over 252%) slow kinetics storage. Herein, we introduce a novel anode design featuring densely packed bismuth (Bi) embedded within...
Background: Cyclic nucleotides play critical roles in cardiovascular biology and disease. PDE10A (phosphodiesterase 10A) is able to hydrolyze both cAMP cGMP. expression induced various human tumor cell lines, inhibition suppresses growth. Chemotherapy drug such as doxorubicin (DOX) widely used chemotherapy. However, cardiotoxicity of DOX remains be a serious clinical complication. In the current study, we aim determine role effect on cancer growth by DOX. Methods: We global knockout (KO)...
Abstract Lysosome‐targeting chimeras (LYTACs) are an emerging therapeutic modality that effectively degrade cancer cell membranes and extracellular target proteins. In this study, a nanosphere‐based LYTAC degradation system is developed. The amphiphilic peptide‐modified N ‐acetylgalactosamine (GalNAc) can self‐assemble into nanospheres with strong affinity for asialoglycoprotein receptor targets. They different proteins by linking the relevant antibodies. CD24, heavily glycosylated...
Abstract The hypoxic nature of solid tumors limits the efficacy radiotherapy (RT) and leads to radiation resistance. Hypoxic radiosensitizers can enhance tumor radiosensitivity by mimicking effects oxygen, but their has been limited heterogeneous oxygen distribution in tissue. Herein, a multimodal therapeutic nanoplatform fabricated co‐encapsulation chlorin e6 tirapazamine (TPZ) with an amphiphilic polymeric conjugate cisplatin (CDDP) metronidazole is reported. This platform could kill...
Banxia Xiexin decoction (BXD) is a classic Chinese herbal formulation consisting of 7 herbs including Pinelliae Rhizoma, Scutellariae Radix, Zingiberis Ginseng Glycyrrhizae Coptidis and Jujubae Fructus, which can exert effects on lowering lipids alleviating depressive mood disorders via affecting gastrointestinal tract.The pathogenesis atherosclerosis (AS) co-depression disease has not been well studied, the current clinical treatment strategies are satisfactory. As result, it critical to...
OBJECTIVE To explore the relationship between serum neuron-specific enolase (NSE) levels and diabetic neuropathy. RESEARCH DESIGN AND METHODS Type 1 or 2 healthy control subjects (n = 568) were randomly enrolled in a cross-sectional study. Diabetic neuropathy status was documented by presence of clinical symptoms signs, electromyography, quantitative sensory tests, cardiac autonomic tests. The severity staged composite scores. Serum NSE measured using electrochemiluminescence immunoassay....
Summary Aims Hypoxia may damage blood‐brain barrier (BBB). The neuroprotective effect of propofol has been reported. We aimed to identify whether and how improved hypoxia‐induced impairment BBB integrity. Methods Mouse brain microvascular endothelial cells (MBMECs) astrocytes were cocultured establish in vitro model. effects hypoxia on integrity examined. Further, zonula occludens‐1 (ZO‐1) expression phosphorylation, hypoxia‐inducible factor‐1α (HIF‐1α) vascular growth factor (VEGF)...
T-helper (Th) cells regulate immunity and inflammation, modulate cognitive impairment in both cardio-cerebrovascular neurological diseases. This study aimed to explore the correlation of longitudinal change Th1/2/17 with prognosis acute ischemic stroke (AIS).Th1/2/17 were detected by flow cytometry peripheral blood samples from 150 AIS patients at admission (baseline), Day (D)1, D3, D7 after admission, 30 controls. Mini-Mental State Examination (MMSE) score among discharge was assessed....
Abstract Immune checkpoint inhibitors (ICIs) show promise as second‐line treatment for advanced bladder cancer (BLCA); however, their responsiveness is limited by the immune evasion mechanisms in tumor cells. This study conduct a Cox regression analysis to screen mRNA‐binding proteins and reveals an association between Ras GTPase‐activating protein‐binding protein 1 (G3BP1) diminished effectiveness of ICI therapy patients with BLCA. Subsequent investigation demonstrates that G3BP1 enhances...
Current evidence points to renin-angiotensin system as a key mediator in ischemia-reperfusion injury. Rosiglitazone, peroxisome proliferator-activated receptor-gamma (PPAR-gamma) ligand, has recently been shown confer cardioprotection against animal models. We sought examine the expression of ANG II receptors during PPAR-gamma-mediated cardioprotection. Male Sprague-Dawley rats (nondiabetic) were fed either regular rat chow (control diet group, n = 9) or rosiglitazone-rich...
Perioperative hypoxia may induce microglial inflammation and apoptosis, resulting in brain injury. The neuroprotective effect of propofol against has been reported, but the underlying mechanisms are far from clear. In this study, we explored whether how could attenuate microglia BV2 cells CoCl2-induced hypoxic injury.Mouse were pretreated with propofol, then stimulated CoCl2. TNF-α level culture medium was measured by ELISA kit. Cell apoptosis intracellular calcium concentration flow...
The levels of tight junction proteins (TJs), especially occludin, correlate with blood-brain barrier (BBB) disruption caused by inflammation in central nervous system (CNS). It has been reported that propofol, the most commonly used anesthetic, could inhibit response CNS. In this study, we investigated effects tumor necrosis factor-α (TNF-α) and propofol on occludin expression human cerebral microvascular endothelial cell line, D3 clone (hCMEC/D3 cells), explored underlying mechanisms....
Many Drosophila species differ widely in their distributions and climate niches, making them excellent subjects for evolutionary genomic studies. Here, we have developed a database of high-quality assemblies 46 one closely related Zaprionus. Fifteen the genomes were newly sequenced, 20 improved with additional sequencing. New or annotations generated all 47 species, assisted by new transcriptomes 19. Phylogenomic analyses these data resolved several previously ambiguous relationships,...
Hypoxia and inflammation may lead to BDNF/TrkB dysregulation neurological disorders. Propofol is an anesthetic with neuroprotective properties. We wondered whether how propofol affected pathway in hippocampal neurons astrocytes.Primary rat astrocytes were cultured exposed followed by hypoxia or TNF-α treatment. The expression of BDNF the expression/truncation/phosphorylation TrkB measured. underlying mechanisms investigated.Hypoxia reduced BDNF, which was reversed pretreatment 25 μM neurons....