A5029637199- Endometrial and Cervical Cancer Treatments
- Ovarian cancer diagnosis and treatment
- Cervical Cancer and HPV Research
- Uterine Myomas and Treatments
- Colorectal and Anal Carcinomas
- Reproductive Biology and Fertility
- Sarcoma Diagnosis and Treatment
- Minimally Invasive Surgical Techniques
- Colorectal Cancer Surgical Treatments
- Estrogen and related hormone effects
- COVID-19 and healthcare impacts
- Intraperitoneal and Appendiceal Malignancies
- Ovarian function and disorders
- Endometriosis Research and Treatment
- MicroRNA in disease regulation
- Extracellular vesicles in disease
- Pelvic and Acetabular Injuries
- Maternal and fetal healthcare
- Advances in Oncology and Radiotherapy
- Pelvic floor disorders treatments
- Circular RNAs in diseases
- Hernia repair and management
- Molecular Biology Techniques and Applications
- Breast Cancer Treatment Studies
- Cardiovascular Issues in Pregnancy
Hospital Universitario La Paz
2007-2024
Hospital La Paz Institute for Health Research
2021-2023
Universidad Autónoma de Madrid
2015-2021
Objective:To analyze the prognostic factors related to recurrence rate of vulvar cancer.Methods: Retrospective study 87 patients diagnosed squamous cell carcinoma at a tertiary hospital in Madrid between January 2000 and December 2010.Results: The pathological mean tumor size was 35.1±22.8mm, with stromal invasion 7.7±6.6mm.The free margin after surgery 16.8±10.5mm.Among all patients, 31 (35.6%)presented local (mean time 10 months; range, 1 114 months) 7 (8%) had distant metastases time, 5...
Objective: To evaluate the oncological outcomes of patients with low-volume metastasis compared to those macrometastasis and negative nodes in endometrial cancer. Methods: A single institutional retrospective study was carried out, which included all cancer who underwent surgical treatment between January 2007 December 2016. We analyzed progression-free survival (PFS) overall (OS) after sentinel node biopsy full nodal staging according their final pathological status, focusing on impact size...
Our aim was to study the advantages, complications and obstetrical outcomes of laparoscopic myomectomy (LM) compared with abdominal (AM). We conducted a retrospective cohort at La Paz University Hospital that included LMs AMs performed between 2012 2018, analyzing 254 myomectomies (142 [55.7%] 112 [43.9%]). The mean number fibroids 1.8 ± 1.5 3 2.9 for LM AM groups, respectively (p < 0.006). size largest myoma 7.6 cm 2.7 10.2 5.4 0.001). were associated longer surgical times 0.001) shorter...
To evaluate the role of sentinel lymph node biopsy (SLNB) to avoid staging lymphadenectomies by detecting nodal metastasis in intermediate- and high-risk endometrial cancer (EC).A single institutional retrospective study was performed including all patients with EC who underwent surgical between January 2012 December 2019. Patients disseminated disease detected on imaging techniques or at time surgery were excluded. evaluable if they SLNB pelvic (PLD) paraaortic (PALD) dissection. We...
The objective of this study was to evaluate the efficacy one-step nucleic acid amplification (OSNA) for detection sentinel lymph node (SLN) metastasis compared standard pathological ultrastaging in patients with early-stage endometrial cancer (EC). A total 526 SLNs from 191 EC were included study, and 379 (147 patients) evaluated by both methods, OSNA ultrastaging. central 1 mm portion each subjected semi-serial sectioning at 200 μm intervals examined hematoxylin–eosin immunohistochemistry...
El carcinoma invasor de cuello uterino es una enfermedad transmisión sexual causada por el virus del papiloma humano (VPH).Entre las nuevas opciones prevención y tratamiento cérvix se incluyen la citología en medio líquido, test ADN VPH vacunas preventivas terapéuticas.Las frente a están basadas producción VLPs o partículas similares al virus.Existen dos tipos vacunas: vacuna bivalente 16 18, tetravalente 6, 11, 18.El desarrollo terapéuticas encuentra aún experimentación.Actualmente próximas...
Pelvic exenteration is an ultraradical surgery involving the en bloc resection of pelvic organs, including internal reproductive distal urinary tract (ureters, bladder, urethra), and/or anorectum. It mainly applied as a salvage for recurrent gynecologic tumors any origin (vulva, vagina, cervix, uterine, and also ovary). Our aim was to establish most favorable cases this type by means review our institution experience.Retrospective analyses all patients treated with cancer from 2008 2014 at...
Abstract Background In an effort to contribute overcoming the platinum resistance exhibited by most solid tumors, we performed array of epigenetic approaches, integrating next-generation methodologies and public clinical data identify new potential epi-biomarkers in ovarian cancer, which is considered devastating gynecological malignancies. Methods We cross-analyzed from methylome assessments restoration gene expression through microarray a panel four paired...
The aim of this study was to evaluate the feasibility and safety single-port extraperitoneal laparoscopic para-aortic lymphadenectomy for patients with gynecologic cancer.From July 2012 January 2013, a total 7 cancer underwent pelvic device. An approach performed using only one 2.5-cm incision on left side. In 6 patients, additionally, hysterectomy conventional laparoscopy were complete treatment.Aortic dissection in all cases without complications. median age 63 years (range, 48-78 years),...
Background: The purpose was to analyze the casuistry of pelvic floor reconstruction (PFR) with biological mesh (BM) after exenterative radical surgery. Methods: Six patients treated surgery and perineal defect, conducted a BM, since April 2011 June 2016, are described. Results: A total 5 exenterations an anterior supralevator exenteration were performed, 2 cases included vulvectomy. In BM placed intraoperatively, combined myocutaneous bilateral gracilis flap or omentoplasty. Another case...
The main objective was to analyze the rate of bilateral sentinel lymph node (SLN) detection in endometrial cancer using indocyanine green (ICG) as a unique tracer compared Technetium99 + ICG. As secondary objectives, we analyzed drainage pattern and factors that might affect oncological outcomes. A case-control ambispective study carried out on consecutive patients at our center. Data SLN biopsy with ICG collected prospectively were retrospective data use double-tracer technique including In...
The benefit of adjuvant radiotherapy (RT) after radical hysterectomy in patients with cervical cancer remains controversial. aim this study was to determine the impact on survival RT according Sedlis criteria. Patients early-stage who underwent between 2005 and 2022 at a single tertiary institution were included. A multivariate analysis performed determinate if an independent prognostic factor for recurrence or death. We also analyzed whether there statistically significant difference...
The SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) pandemic changed the distribution of healthcare resources, leading in many cases to suspension all non-essential treatments and procedures representing a challenge for medical professionals. objective this study was evaluate whether clinical protocols gynecologic oncology care were modified as result assess surgeons' perceptions regarding management cancers".Data collected through an anonymous voluntary survey sent via email...
The benefit of adjuvant radiotherapy (RT) after radical hysterectomy in patients with cervical cancer remains controversial. aim this study was to determine RT's impact on survival accordance Sedlis criteria. Patients early-stage undergoing between 2005 and 2022 at a single tertiary care institution were included. A multivariate analysis performed determinate if RT an independent prognostic factor for recurrence or death. We also analysed whether there statistically significant difference...