A5068972548- COVID-19 and healthcare impacts
- Lung Cancer Diagnosis and Treatment
- CAR-T cell therapy research
- Prostate Cancer Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Moringa oleifera research and applications
- Prostate Cancer Treatment and Research
- Advancements in Semiconductor Devices and Circuit Design
- Nanowire Synthesis and Applications
- Health Systems, Economic Evaluations, Quality of Life
- Breast Implant and Reconstruction
- Colorectal Cancer Treatments and Studies
- Monoclonal and Polyclonal Antibodies Research
- Viral Infections and Vectors
- Genetic factors in colorectal cancer
- Glaucoma and retinal disorders
- Cancer-related gene regulation
- Circular RNAs in diseases
- Body Contouring and Surgery
- MicroRNA in disease regulation
- RNA modifications and cancer
- COVID-19 Clinical Research Studies
- Mosquito-borne diseases and control
- Gastric Cancer Management and Outcomes
- Pharmaceutical Economics and Policy
Universidad De Santander
2019-2025
Ajinomoto (United States)
2024
Florida International University
2024
Hospital General Universitario Gregorio Marañón
2020-2023
Universidad de Santander
2020-2022
Centro Científico Tecnológico - Tandil
2021
Helmholtz-Zentrum Dresden-Rossendorf
2021
Hospital Universitario La Paz
2014-2018
Hospital Universitario Puerta del Mar
2015
Hospital La Paz Institute for Health Research
2014-2015
One of the major limitations associated with platinum use is resistance that almost invariably develops in different tumor types.In current study, we sought to identify epigenetically regulated microRNAs as novel biomarkers lung and ovarian cancers, ones highest ratios chemo-resistance.Methods: We combined transcriptomic data from microRNA mRNA under influence an epigenetic reactivation treatment a panel four paired cisplatin -sensitive -resistant cell lines, followed by real-time expression...
<ns3:p>Background Gastric cancer is the fifth most common and third leading cause of deaths worldwide. Perioperative or adjuvant chemotherapy improves survival in patients with stage 1B higher cancers. <ns3:italic>Moringa oleifera</ns3:italic> <ns3:italic>Plukenetia volubilis</ns3:italic> (Sacha inchi) have been reported to enhance various biological functions, including antitumor antiproliferative activity. Methods In order evaluate this potential present crude extracts leaves these plants,...
Cancer patients represent a vulnerable population for COVID-19 illness. We aimed to analyze outcomes of lung cancer affected by in tertiary hospital high-incidence region during the pandemic.
Chimeric antigen receptor (CAR) T cells have shown impressive therapeutic potential. Due to the lack of direct control mechanisms, therapy-related adverse reactions including cytokine release- and tumor lysis syndrome can even become life-threatening. In case target expression on non-malignant cells, CAR also attack healthy tissues. To overcome such side effects, we established a modular platform termed UniCAR: UniCAR per se are inert as they recognize peptide epitope (UniCAR epitope) that...
Decades ago, we and many other groups showed a nucleo-cytoplasmic translocation of La protein in cultured cells. This shuttling was seen after UV irradiation, virus infections, hydrogen peroxide exposure the Fenton reaction based on iron or copper ions. All these conditions are somehow related to oxidative stress. Unfortunately, harsh could also cause an artificial release protein. Even until today, cytoplasmic function La/SS-B is controversially discussed. Moreover, driving mechanism for...
Abstract Recently, we established the controllable modular UniCAR platform technology to advance efficacy and safety of CAR T cell therapy. The system is composed (i) target modules (TMs) (ii) armed cells. TMs are bispecific molecules that able bind tumor surface simultaneously For interaction with cells, contain a peptide epitope sequence which recognised by So far, series against variety targets including prostate stem antigen (PSCA) were constructed functionally characterised. In order...
The methylation status of the IGFBP-3 gene is strongly associated with cisplatin sensitivity in patients non-small cell lung cancer (NSCLC). In this study, we found vitro evidence that linked presence an unmethylated promoter poor response to radiation. Our data also indicate radiation might sensitize chemotherapy-resistant cells by reactivating IGFBP-3-expression through demethylation, inactivating PI3K/AKT pathway. We explored effect on overall survival (OS) a population 40 NSCLC who...
Abstract Background In an effort to contribute overcoming the platinum resistance exhibited by most solid tumors, we performed array of epigenetic approaches, integrating next-generation methodologies and public clinical data identify new potential epi-biomarkers in ovarian cancer, which is considered devastating gynecological malignancies. Methods We cross-analyzed from methylome assessments restoration gene expression through microarray a panel four paired...
Toxoplasmosis is a zoonosis prevalent in one-third of the world's population, adversely affecting maternal-fetal health by causing varying degrees damage to fetus. Objective: To assess seroprevalence Toxoplasma gondii IgG and IgM antibodies associated risk factors first- trimester pregnant women Cúcuta, Colombia, 2018. Cross-sectional correlational study 111 who voluntarily participated. Specific were detected luminescence immunoassay (LIA). Total seropositivity for was 19.8% 35.1%,...
Worldwide, iron deficiency anaemia (IDA) is one the most significant nutritional maladies, especially in low and middle-income countries. This mainly due to associated morbidity, economic implications on health system welfare state. One of prevalent causes IDA children insufficient food intake, which has an obvious connection with social environment. The main strategy management this condition counteracting such through improvement nutrition family upbringing. Aiming explore affordable,...
15111 Background: Molecular studies have demonstrated a direct relationship between human papillomavirus (HPV) infection and invasive cervical cancer, as well cancer of the anal region. The role HPV in colorectal has not been properly elucidated. Our objetive was to evaluate presence mucosa its association with colon rectal carcinomas. Methods: We analyzed tissue samples from 70 sporadic patients (30 40 rectal) 3 canal cancers, diagnosed at our hospital. Normal tumor each patient were...
Here we report a case of human brucellosis due to Brucella suis in person who worked small-scale pig farm. The farm had no history clinical brucellosis, and signs the disease were not observed upon examination animals. Serum from all 3 boars, 16/22 sows 9/25 gilts was obtained for serological by Buffered Plate Agglutination Test (BPAT), Rose Bengal (RBT) Fluorescent Polarization Assay (FPA). Bacteriological culture Direct Fluorescence Antibody (DFAT) performed tissue samples seropositive...