A5086741053- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Radiopharmaceutical Chemistry and Applications
- Medical Imaging Techniques and Applications
- Cancer, Hypoxia, and Metabolism
- Inflammatory mediators and NSAID effects
- S100 Proteins and Annexins
- Crystallography and molecular interactions
- Adrenal and Paraganglionic Tumors
- Peptidase Inhibition and Analysis
- Axon Guidance and Neuronal Signaling
- Boron Compounds in Chemistry
- Blood properties and coagulation
- Advanced Glycation End Products research
- Lipoproteins and Cardiovascular Health
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Antioxidant Activity and Oxidative Stress
- Bone health and treatments
- Hormonal Regulation and Hypertension
- Angiogenesis and VEGF in Cancer
- Atherosclerosis and Cardiovascular Diseases
- Monoclonal and Polyclonal Antibodies Research
- Neuroblastoma Research and Treatments
- 3D Printing in Biomedical Research
- Neuroendocrine Tumor Research Advances
TU Dresden
2016-2025
Helmholtz-Zentrum Dresden-Rossendorf
2016-2025
University of Zurich
2023
University Hospital Carl Gustav Carus
1998-2023
University Hospital of Zurich
2023
Universitätsklinikum Würzburg
2023
Ludwig-Maximilians-Universität München
2023
Institute of Cancer Research
2014-2020
Essen University Hospital
2012
University Medical Center Utrecht
2012
Abstract Many features of extracellular matrices, e.g., self-healing, adhesiveness, viscoelasticity, and conductivity, are associated with the intricate networks composed many different covalent non-covalent chemical bonds. Whereas a reductionism approach would have limitation to fully recapitulate various biological properties simple structures, mimicking such sophisticated by incorporating functional groups in macromolecular system is synthetically challenging. Herein, we propose strategy...
Abstract Recent oncological studies identified beneficial properties of radiation applied at ultrahigh dose rates, several orders magnitude higher than the clinical standard order Gy min –1 . Sources capable providing these rates are under investigation. Here we show that a stable, compact laser-driven proton source with energies greater 60 MeV enables radiobiological in vivo studies. We performed pilot irradiation study on human tumours mouse model, showing concerted preparation mice and...
Hydrogels based on gelatin have evolved as promising multifunctional biomaterials.Gelatin is crosslinked with lysine diisocyanate ethyl ester (LDI) and the molar ratio of LDI in starting material mixture determines elastic properties resulting hydrogel.In order to investigate clinical potential these biopolymers, hydrogels different ratios (3-fold (G10_LNCO3) 8-fold (G10_LNCO8) excess isocyanate groups) were subcutaneously implanted mice (uni-or bilateral implantation).Degradation...
// Anja Feldmann 1, * , Claudia Arndt Ralf Bergmann Simon Loff 2, 3, Marc Cartellieri 4, Dominik Bachmann ** Roberta Aliperta Mirjam Hetzenecker Florian Ludwig Susann Albert Pauline Ziller-Walter Alexandra Kegler Stefanie Koristka Sebastian Gärtner Schmitz 5, 7, 8 Armin Ehninger 3 Gerhard 6, Jens Pietzsch 9 Jörg Steinbach 8, and Michael 1 Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Institute of Radiopharmaceutical Cancer Research, Dresden, Germany 2 UniversityCancerCenter (UCC)...
Recent treatments of leukemias with chimeric antigen receptor (CAR) expressing T cells underline their impressive therapeutic potential. However, once adoptively transferred into patients, there is little scope left to shut them down after elimination tumor or in case adverse side effects occur. This becomes special relevance if they are directed against commonly expressed associated antigens (TAAs) such as receptors the ErbB family. To overcome this limitation, we recently established a...
Abstract Synthetic conductive biopolymers have gained increasing interest in tissue engineering, as they can provide a chemically defined electroconductive and biomimetic microenvironment for cells. In addition to low cytotoxicity high biocompatibility, injectability adhesiveness are important many biomedical applications but proven be very challenging. Recent results show that fascinating material properties realized with bioinspired hybrid network, especially through the synergy between...
Pheochromocytomas and paragangliomas (PPGLs) with pathogenic mutations in the succinate dehydrogenase subunit B (SDHB) are associated a high metastatic risk. Somatostatin receptor 2 (SSTR2)-dependent imaging is most sensitive modality for SDHB-related PPGLs, suggesting that SSTR2 expression significant cell surface therapeutic biomarker of such tumors.Exploration relationship between immunoreactivity SDHB immunoreactivity, mutational status, clinical behavior PPGLs. Evaluation SSTR-based...
Detection of antigens and antibodies (Abs) is great importance in determining the infection immunity status population, as they are key parameters guiding handling pandemics. Current point-of-care (POC) devices a convenient option for rapid screening; however, their sensitivity requires further improvement. We present an interdigitated gold nanowire-based impedance nanobiosensor to detect COVID-19-associated (receptor-binding domain S1 protein SARS-CoV-2 virus) respective Abs appearing...
Eph receptors and their ephrin ligands were identified in the late 1980's. Subsequently, they linked to different physiological pathophysiological processes like embryonic development, angiogenesis, tumorigenesis. In this regard, recent work focused on distribution effects of ephrins tumor cells microenvironment. The purpose review is outline role these molecules angiogenesis angiogenesis. Furthermore, novel therapeutical approaches are discussed as represent attractive targets for...
The epidermal growth factor receptor (EGFR) has evolved over years into a main molecular target for the treatment of different cancer entities. In this regard, anti-EGFR antibody cetuximab been approved alone or in combination with: (a) chemotherapy colorectal and head neck squamous cell carcinoma (b) with external radiotherapy carcinoma. conjugation radionuclides to specific targeting properties might increase its therapeutic efficiency. This review article gives an overview preclinical...
CAR-modified T cells show impressive results in clinical trials. However, cytokine release syndrome and "on-target, off-tumor" reactions represent most concerning side effects. To improve the safety of CAR-T cell therapy, we established a switchable CAR platform termed UniCAR system consisting two components: UniCAR-modified tumor-specific target modules (TM). For treatment EGFR
Oxidized LDL (oxLDL) is a key mediator in atherogenesis and marker of coronary artery disease (CAD). Type 2 diabetes associated with excessive cardiovascular morbidity mortality. Because starts before diagnosed, we investigated whether circulating oxLDL levels are increased impaired glucose tolerance (IGT). OxLDL were measured 376 subjects normal (NGT), 113 patients IGT, 54 newly diagnosed type diabetes. After correction for age BMI, serum significantly IGT versus NGT (P = 0.002). not the...
2-[18F]Fluoro-2-deoxy-d-glucose ([18F]FDG) as the most important PET radiotracer is available in almost every center. However, there are only very few examples using [18F]FDG a building block for synthesis of 18F-labeled compounds. The present study describes use peptides and proteins. was converted into [18F]FDG-maleimidehexyloxime ([18F]FDG-MHO), novel [18F]FDG-based prosthetic group mild thiol group-specific 18F labeling reaction performed at 100 °C 15 min sealed vial containing...
Expression of system L amino acid transporters (LAT) is strongly increased in many types tumor cells. The purpose this study was to demonstrate that <sup>18</sup>F-labeled acids, for example, 3-<i>O</i>-methyl-6-<sup>18</sup>F-fluoro-l-dopa (<sup>18</sup>F-OMFD), accumulate tumors via LAT represent an important class imaging agents visualization vivo by PET. <b>Methods:</b><sup>18</sup>F-OMFD uptake kinetics, transport inhibition, and messenger RNA expression were studied vitro human...