A5019298730- Microscopic Colitis
- Helicobacter pylori-related gastroenterology studies
- Blood Coagulation and Thrombosis Mechanisms
- Venous Thromboembolism Diagnosis and Management
- Dental Implant Techniques and Outcomes
- Forensic and Genetic Research
- Hemophilia Treatment and Research
- Gastroesophageal reflux and treatments
- Veterinary medicine and infectious diseases
- Bone Tissue Engineering Materials
- Clostridium difficile and Clostridium perfringens research
- Aortic aneurysm repair treatments
- Platelet Disorders and Treatments
- Inflammatory Bowel Disease
- Atrial Fibrillation Management and Outcomes
- Protease and Inhibitor Mechanisms
- Nitric Oxide and Endothelin Effects
- Pancreatic and Hepatic Oncology Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Infectious Aortic and Vascular Conditions
- Potassium and Related Disorders
- Genetic Associations and Epidemiology
- Gastric Cancer Management and Outcomes
- Congenital gastrointestinal and neural anomalies
- Periodontal Regeneration and Treatments
University Hospital Carl Gustav Carus
2003-2017
TU Dresden
2007-2017
Zimmer Biomet (Germany)
2004-2014
Institut für Medizinische Informatik, Biometrie und Epidemiologie
1998-2014
Carl Gustav Carus-Institut
2007
Universidade Federal do Rio de Janeiro
2006
Vanderbilt University
2005
Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology
2005
Goethe University Frankfurt
2005
University Hospital Frankfurt
2005
Patients receiving novel oral anticoagulants (NOACs) frequently undergo interventional procedures. Short half-lives and rapid onset of action allow for short periods NOAC interruption without heparin bridging. However, outcome data this approach are lacking. We evaluated the peri-interventional management in unselected patients from daily care. Effectiveness safety were collected an ongoing, prospective, non-interventional registry >2100 patients. Outcome events adjudicated using standard...
Yttria-stabilized zirconia ceramics is a high-performance material with excellent biocompatibility and mechanical properties, which suggest its suitability for posterior fixed partial dentures. The hypothesis under examination that the strength reliability of Y-TZP are affected by inner surface grinding crowns, vary parameter. Flexural strength, roughness, fracture toughness were determined on samples machined face peripheral varied feed velocities cutting depths. Results have been compared...
To investigate a correlation between cigarette smoking and keratoconus.Patients with keratoconus who were treated corneal collagen cross-linking from June 2006 to November 2007 asked about their habits. A person minimum of two cigarettes per day for more than 1 year was classified as smoker.A total 180 patients (mean age 28 +/- 9 years [range: 15 41 years]) One hundred seventy-one (95%) non-smokers only (5%) smokers (95% confidence interval, 2.31 9.28). Using the chi-square test, significant...
Histological imaging is still considered the gold standard for analysing bone formation around metallic implants.Generally, a limited number of histological sections per sample are used approximation mean values peri-implant formation.In this study we compared statistically results bone-implant contact (BIC) and volume (BIV) obtained by sections, with those X-ray absorption images from synchrotron radiation micro-computed tomography (SRμCT) using osseointegrated screw-shaped implants...
Background:The risk for venous thromboembolism after long-haul flights represents a controversial issue.The aim of our study was to assess the incidence thrombosis associated with in prospective, controlled cohort study. Methods:We included 964 passengers returning from (flight duration, Ն8 hours) and 1213 nontraveling control subjects.We excluded participants who were being treated anticoagulant drugs or used compression stockings.Main outcome measures ultrasonographically diagnosed calf...
Objectives Our objectives were to evaluate the effect of single and repeated grapefruit juice ingestion relative water on oral pharmacokinetics nonmetabolized P-glycoprotein-transported drug talinolol in humans assess potential impact P-glycoprotein intestinal uptake transporters. Methods The 50 mg was determined with water, 1 glass (300 mL), after 6 days (900 mL/d) 24 healthy white volunteers. MDR1 messenger ribonucleic acid levels measured duodenal biopsy specimens obtained from 3...
Abstract Objective Human urate transporter 1 (hURAT1) is a member of the organic anion family (SLC22A12) that mainly regulates tubular reabsorption. Loss‐of‐function mutations result in idiopathic hypouricemia. The present case–control study was designed to analyze whether hURAT1 might also be candidate gene for hyperuricemia with primary reduced renal excretion. Methods DNA samples from 389 individuals fractional excretion uric acid (FEUA) (≤6.5%) and 263 controls (FEUA >6.5%) were...
St John's wort (SJW) is known to induce cytochrome P450 (CYP) 3A4 and P-glycoprotein through pregnane X-receptor activation. Our study evaluated the effects of long-term SJW administration on oral intravenous pharmacokinetics nonmetabolized in vivo probe P-glycoprotein, talinolol, relation intestinal expression. In a controlled, randomized (N=9), (50 mg) talinolol (30 was determined before after 12 days (900 mg daily, Jarsin 300®). Duodenal biopsies were taken MDR1 genotypes assessed....
Oxidized LDL (oxLDL) is a key mediator in atherogenesis and marker of coronary artery disease (CAD). Type 2 diabetes associated with excessive cardiovascular morbidity mortality. Because starts before diagnosed, we investigated whether circulating oxLDL levels are increased impaired glucose tolerance (IGT). OxLDL were measured 376 subjects normal (NGT), 113 patients IGT, 54 newly diagnosed type diabetes. After correction for age BMI, serum significantly IGT versus NGT (P = 0.002). not the...
Summary Background: Budesonide (Entocort) is effective for the treatment of collagenous colitis. Aim: To assess long‐term outcome patients after induction clinical remission by budesonide treatment. Methods: Fifty‐one with chronic diarrhoea and histologically proven colitis were enrolled in randomized, placebo‐controlled crossover trial using 9 mg daily 6 weeks. Patients either initial or followed standardized questionaires. Clinical relapse was defined as five more loose stools/day at least...
Summary Background The clinical management of Helicobacter pylori infected patients who failed standard eradication therapies remains a challenge. Aim To investigate the efficacy rifabutin‐based triple therapy and high‐dose dual for rescue treatment H. , correlation between cytochrome P450 2C19 (CYP2C19) polymorphisms outcome. Methods Patients with resistant to both metronidazole clarithromycin ( n = 145) were randomized either esomeprazole 20 mg, rifabutin 150 mg amoxicillin 1 g, each given...
Vitamin-K antagonists (VKA) and non-vitamin-K dependent oral anticoagulants (NOAC) have been approved for anticoagulation in venous thromboembolism (VTE) atrial fibrillation patients previously treated with VKA are switched to NOAC therapy. Safety data this switching urgently needed.Using from a large regional prospective registry of daily care patients, we evaluated the safety dabigatran or rivaroxaban. Switching procedures cardiovascular bleeding events occurring within 30 days after were...
A C825T polymorphism was recently identified in the human gene encoding for beta(3)-subunit of heterotrimeric G proteins. The 825T allele is associated with a splice variant Gbeta(3) and enhanced signal transduction. We hypothesized that patients carrying exhibit modified phenotype. resulting enhancement transduction should be detectable Gbetagamma-dimer-mediated acetylcholine-stimulated K(+) current (I(K,ACh)).Seventy undergoing cardiac surgery were genotyped polymorphism. In right atrial...