A5061438432- Synthesis and biological activity
- Microtubule and mitosis dynamics
- Cancer therapeutics and mechanisms
- Advanced Chemical Physics Studies
- Inflammatory mediators and NSAID effects
- Microbial Natural Products and Biosynthesis
- Synthesis of Tetrazole Derivatives
- Photoreceptor and optogenetics research
- Spectroscopy and Quantum Chemical Studies
- Enhanced Oil Recovery Techniques
- Hydrocarbon exploration and reservoir analysis
- Petroleum Processing and Analysis
- 14-3-3 protein interactions
- Inorganic Fluorides and Related Compounds
- Advanced Biosensing Techniques and Applications
- Geomechanics and Mining Engineering
- Crystal structures of chemical compounds
- Supramolecular Self-Assembly in Materials
- Mineral Processing and Grinding
- Biofield Effects and Biophysics
- Crystallography and molecular interactions
- Synthesis and Reactions of Organic Compounds
- Synthesis and Biological Evaluation
- Advanced biosensing and bioanalysis techniques
- Molecular Spectroscopy and Structure
Natural Resources Canada
2019-2024
Devon Energy (United States)
2021
Centre Hospitalier Universitaire de Montpellier
2018
Université de Montpellier
2018
University of Alberta
2004-2017
National Institute for Nanotechnology
2016
National Research Council Canada
2016
It was once purported that biological systems were far too ‘warm and wet’ to support quantum phenomena mainly owing thermal effects disrupting coherence. However, recent experimental results theoretical analyses have shown energy may assist, rather than disrupt, coherent transport, especially in the ‘dry’ hydrophobic interiors of biomolecules. Specifically, evidence has been accumulating for necessary involvement transfer between uniquely arranged chromophores light harvesting photosynthetic...
Abstract Background A maximum entropy approach is proposed to predict the cytotoxic effects of a panel colchicine derivatives in several human cancer cell lines. Data was obtained from cytotoxicity assays performed with 21 drug molecules same family compounds and correlate these results independent tubulin isoform expression measurements for The method then used conjunction computed relative binding energy values each against isotypes which bind different affinities. Results We have found by...
Aptamers are short RNA/DNA sequences that identified through the process of systematic evolution ligands by exponential enrichment and bind to diverse biomolecular targets. have strong specific binding molecular recognition promising tools in studying biology. They recognized as having potential therapeutic diagnostic clinical applications. The success requires pools used a sufficient level sequence diversity structural complexity. While technology is well developed, it remains challenge...
Recent studies have shown an overexpression of γ-tubulin in human glioblastomas and glioblastoma cell lines. As the 2-year survival rate for is very poor, potential benefit exists discovering novel chemotherapeutic agents that can inhibit γ-tubulin, which known to form a ring complex acts as microtubule nucleation center. We present experimental evidence colchicine combretastatin A-4 bind are our knowledge first drug-like compounds interact with γ-tubulin. Molecular dynamics simulations...
Human α-synuclein (αS) is an intrinsically disordered protein associated with Parkinson's disease. Molecular mechanisms of corruptive misfolding and aggregation αS resulting in the disease, as well structure other properties corresponding oligomers are not entirely understood yet, preventing development efficient therapies. In this study, we investigate folding dynamics initially unfolded hypothetical constructs water using all-atom molecular simulations. We also employ novel essential...
Tubulin is the target for numerous small molecule ligands which alter microtubule dynamics leading to cell cycle arrest and apoptosis. Many of these are currently used clinically treatment several types cancer, they bind one three distinct binding sites within beta-tubulin (paclitaxel, vinca, colchicine), all have been identified crystallographically. Unfortunately, serious side effects always accompany chemotherapy since drugs tubulin indiscriminately, death both cancerous healthy cells....
Understanding the interactions of petroleum asphaltenes with mineral surfaces is important for diluted bitumen spill response and modeling. In this study, molecular dynamics umbrella sampling simulations are performed using interfacially active non-interfacially asphaltene model compounds individually positioned near each kaolinite in presence explicit solvent environments containing water, toluene, mixtures toluene water varying proportions. The bonds strongest to silicon oxide surface pure...
The binding free energies on human tubulin of selected colchicine and thiocolchicine compounds were determined. Two methods used for the determination energies: one is based theoretical prediction simulating dissociation compound from using a series molecular dynamics simulations, other method involves experiments that measured affinity synthetically expressed purified protein spectrofluorometric technique.
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at glance that was extracted from about 200 leading journals. To access of an article which published elsewhere, please select “Full Text” option. The original trackable via the “References”
In cardiopulmonary diseases, capillary recruitment likely affects both the membrane conductance (DmCO) and pulmonary volume (Vc). We aimed to verify whether DLNO/CO test, according ERS Taskforce (2017) was feasible in patients with congenital heart diseases (CHD) discriminative from healthy subjects. <b>Method:</b> included 28 young adults CHD (53 % Fontan procedure, 41 regurgitation, 6 systemic right ventricle) 13 DLNO-CO test performed on each subject while seated then supine position....