A5100419895- Microtubule and mitosis dynamics
- Hippo pathway signaling and YAP/TAZ
- Endoplasmic Reticulum Stress and Disease
- Wnt/β-catenin signaling in development and cancer
- Autophagy in Disease and Therapy
- Cell Adhesion Molecules Research
- Cancer Cells and Metastasis
- Cellular Mechanics and Interactions
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Cancer, Hypoxia, and Metabolism
- Ultrasound and Hyperthermia Applications
- Glutathione Transferases and Polymorphisms
- Lipid metabolism and disorders
- ATP Synthase and ATPases Research
- Cancer-related molecular mechanisms research
- Calpain Protease Function and Regulation
- Ubiquitin and proteasome pathways
- Breast Cancer Treatment Studies
- Diet, Metabolism, and Disease
- Machine Learning and Algorithms
- Advanced Multi-Objective Optimization Algorithms
- DNA Repair Mechanisms
- 14-3-3 protein interactions
- Pancreatitis Pathology and Treatment
First Affiliated Hospital of Xi'an Jiaotong University
2011-2025
China Medical University
2017-2024
Liaoning Cancer Hospital & Institute
2024
Institute of Biophysics
2015-2022
Chinese Academy of Sciences
2015-2022
Peking University
2022
McGovern Institute for Brain Research
2022
State Key Laboratory of Membrane Biology
2022
Sun Yat-sen University
2021
State Key Laboratory of Biotherapy
2019
Cardiac ischemia/reperfusion (I/R) injury has emerged as an important therapeutic target for ischemic heart disease, the leading cause of morbidity and mortality worldwide. At present, there is no effective therapy reducing cardiac I/R injury. CaMKII (Ca2+/calmodulin-dependent kinase II) plays a pivotal role in pathogenesis severe conditions, including Pharmacological inhibition strategy protection against myocardial damage diseases. To date, drug targeting clinical disease. Furthermore, at...
Abstract Background Breast cancer stem cell (CSC) expansion results in tumor progression and chemoresistance; however, the modulation of CSC pluripotency remains unexplored. Transmembrane protein 120B (TMEM120B) is a newly discovered expressed human tissues, especially malignant tissues; its role has not been studied. This study aimed to determine TMEM120B transcriptional coactivator with PDZ-binding motif (TAZ)-mediated chemotherapy resistance. Methods Both bioinformatics analysis...
The scaffolding protein WWC (WW and C2-domain containing) family is known to regulate cell proliferation organ size via the Hippo signalling pathway. However, expression level of WWC3 in human tumours mechanisms underlying its role cellular signal transduction have not yet been reported. Herein, we explored potential roles lung cancer cells corresponding molecular mechanisms. We found low both lines specimens, which was associated with differentiation, advanced pTNM stage, positive lymph...
IL-1β was considered as an important inflammatory cytokine in diabetic cardiovascular complications. DCM is one of the major manifestations complications whose specific mechanisms are still unclear. In this study, we investigated role myocytes apoptosis DCM. vitro high- glucose medium and/or were used to incubate isolated primary myocytes. siRNA knockdown irak2 gene expression. Apoptosis evaluated by Hoechst and TUNEL staining. vivo rats induced STZ injection confirmed cardiac hemodynamic...
Abstract Autoinhibition of kinesin-3 ensures the proper spatiotemporal control motor activity for intracellular transport, but underlying mechanism remains elusive. Here, we determine full-length structure KLP-6 in a compact self-folded state. Unexpectedly, all internal coiled-coil segments and domains cooperate to successively lock down neck domains. The first segment is melted into several short helices that work with domain restrain entire domain. second associates its neighboring FHA MBS...
Abstract Myocardial ischemia–reperfusion injury (MI/RI) not only affects cardiac function but also has significant implications for neurological health, potentially leading to cognitive and behavioral impairments. At present, the regulatory role of thrombospondin-4 (TSP-4) in MI/RI been reported. A mouse model was constructed, primary cardiomyocytes were isolated. An vitro cell constructed using hypoxia/reoxygenation (H/R)-induced H9c2 cells. Haematoxylin eosin Masson staining performed...
Lipid accumulation in non-adipose tissues leads to cell dysfunction and apoptosis, a phenomenon known as lipotoxicity. Unsaturated fatty acids may offset the lipotoxicity associated with saturated acids. Stearic acid induced endoplasmic reticulum (ER) stress caused apoptotic necrotic death primary rat hepatocytes.Cell viability was investigated using MTT assay, apoptosis evaluated Hoechst 33342 staining. Western blot analysis used examine changes expression levels of glucose regulated...
Overweight/obesity is a chronic disease that carries an increased risk of hypertension, diabetes mellitus, and premature death. Several epidemiological studies have demonstrated clear relationship between salt intake obesity, but the pathophysiologic mechanisms remain unknown. We hypothesized ghrelin, which regulates appetite, food intake, fat deposition, becomes elevated when one consumes high-salt diet, contributing to progression obesity. We, therefore, investigated fasting ghrelin...
Abstract SCL/TAL1 interrupting locus (STIL) regulates the mitotic centrosome to promote centriolar replication and cell cycling, is associated with malignancies. However, role mechanism of STIL in gastric cancer (GC) remain elusive. expression GC tissue microarray was detected by immunohistochemistry (IHC). cells were transduced control lentivirus or for STIL‐specific shRNA effect silencing on malignant behaviors measured vitro vivo. The potential mechanisms underlying action analyzed...
Disruption of early mitotic inhibitor 1 (Emi1) interferes with normal cell cycle progression and results in embryonic lethality vertebrates. During S G2 phases the ubiquitin ligase complex APC/C is inhibited by Emi1 protein, thereby enabling accumulation Cyclins A B so they can regulate replication promote transition from phase to mitosis, respectively. Depletion prevents entry causes rereplication an increase size. In this study, we show that developmental defects caused inactivation...
Single nucleotide polymorphisms (SNPs) in the telomere-associated gene ACYP2 are associated with increased lung cancer risk. We explored correlation between SNPs and susceptibility Chinese Han population. A total of 554 patients 603 healthy controls were included this study. Thirteen selected. Odds ratios (ORs) 95% confidence intervals (95% CIs) calculated using unconditional logistic regression analysis. Multivariate analysis was used assess cancer. found that rs1682111 risk recessive model...
A previous study from our group using an in vivo model demonstrated that diet induced-obesity increases the risk of gastric cancer and may prompt its growth. However, molecular mechanisms underlying this association remain unclear require further investigation. The aim present was to investigate potential through which obesity affects In a subcutaneous mouse model, tumors were significantly larger obese mice compared with non-obese lean mice. addition, markedly increased levels Sirt1 YAP...
Abstract Many methods are used to locate preoperative small pulmonary nodules. However, deficiencies of complications and success rates exist. We introduce a novel magnetic gel for nodules localization in rabbit model, furtherly evaluate its safety feasibility. Rabbits were as the experimental objects. A was tracer magnet, mixed sodium alginate-Fe 3 O 4 fluid calcium gluconate solution. In short-term localization, coaxial double-cavity puncture needle applied inject into lung after...
Laparoscopic surgery based on magnetic anchor technique has great potential for further minimally invasive and good surgical field exposure, in which the internal grasper is key factor. In this paper, an laparoscopic designed, consists of three parts:target magnet, connection module tissue forceps. The shield shell used to wrap core target not only can increase force working area, but also reduce interference between instruments, connecting flexibly adjust length grasper. special structure...
169 Background: To evaluate whether cardiac biomarkers, ultrasonic integrated backscatter (IBS) can predict early myocardial damage in breast cancer patients treated with postoperative adjuvant radiotherapy. Methods: Forty-eight left-sided modified radical mastectomy and non-anthracycline containing chemotherapy regimen were examined. Baseline blood samples drawn for markers analysis, including Troponin T (TnT), C-reactive protein (CRP), brain natriuretic peptide (BNP). Calibrated IBS...