A5100446495- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Organic Light-Emitting Diodes Research
- Ferroptosis and cancer prognosis
- Luminescence and Fluorescent Materials
- Cancer-related gene regulation
- Renal Diseases and Glomerulopathies
- RNA Research and Splicing
- Microtubule and mitosis dynamics
- Epigenetics and DNA Methylation
- RNA and protein synthesis mechanisms
- Sulfur-Based Synthesis Techniques
- Plant and animal studies
- Systemic Sclerosis and Related Diseases
- Mitochondrial Function and Pathology
- Vasculitis and related conditions
- Radical Photochemical Reactions
- Organic Electronics and Photovoltaics
- CO2 Reduction Techniques and Catalysts
- Carbon dioxide utilization in catalysis
- Metal-Organic Frameworks: Synthesis and Applications
- Insect and Arachnid Ecology and Behavior
- Conducting polymers and applications
- Catalytic Cross-Coupling Reactions
- Insect and Pesticide Research
Peking University
2017-2025
National Synchrotron Radiation Laboratory
2023-2025
University of Science and Technology of China
2023-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2021-2025
Peking Union Medical College Hospital
2025
Beijing Academy of Artificial Intelligence
2025
Xi'an Jiaotong University
2024-2025
China-Japan Friendship Hospital
2023-2024
Jiangsu Normal University
2024
Fourth Affiliated Hospital of Guangxi Medical University
2023-2024
As a kind of photoluminescent material, CuI complexes have many advantages such as adjustable emission, variable structures, and low cost, attracting attention in fields. In this work, two novel two-coordinate -N-heterocyclic carbene were synthesized, they exhibit unique dual emission properties, fluorescence phosphorescence. The crystal structure, packing mode, photophysical properties under different conditions systematically studied, proving the emissive mechanism to be locally excited...
Abstract Divalent europium 5 d -4 f transition has aroused great attention in many fields, a way of doping Eu 2+ ions into inorganic solids. However, molecular complexes with are thought to be too air-unstable explore their applications. In this work, we synthesized four -containing azacryptates X 2 -N n ( = Br, I, 4, 8) and systematically studied the photophysical properties crystalline samples solutions. Intriguingly, 8 exhibit near-unity photoluminescence quantum yield, good...
Cardiac ischemia/reperfusion (I/R) injury has emerged as an important therapeutic target for ischemic heart disease, the leading cause of morbidity and mortality worldwide. At present, there is no effective therapy reducing cardiac I/R injury. CaMKII (Ca2+/calmodulin-dependent kinase II) plays a pivotal role in pathogenesis severe conditions, including Pharmacological inhibition strategy protection against myocardial damage diseases. To date, drug targeting clinical disease. Furthermore, at...
Pushing the performance limit of catalysts is a major goal CO2 electroreduction toward practical application. A single-atom catalyst recognized as solution for achieving this goal, which is, however, double-edged sword considering limited loading amount and stability sites. To overcome limit, single atoms on supports should be well addressed, requiring suitable model system. Herein, we report system an ultrasmall CeO2 cluster (2.4 nm) with atomic precise structure high surface-to-volume...
Abstract Background Cancers aggressively reorganize collagen in their microenvironment, leading to the evasion of tumor cells from immune surveillance. However, biological significance and molecular mechanism alignment breast cancer (BC) have not been well established. Methods In this study, BC-related RNA-Seq data were obtained TCGA database analyze correlation between DDR1 cells. Mouse BC EO771 selected for vitro validation, dual-luciferase experiments conducted examine effect TFAP2A on...
Nondoped OLEDs utilizing a new emitter exhibited EL with NTSC CIE<sub>y</sub> and high EQE<sub>max</sub> (5.80%) low efficiency roll-off.
Abstract Background Increasing evidence has demonstrated the critical roles of mRNA modification regulators on multiple types cancers. However, it is still poorly known about prognostic and therapeutic value in HNSCC. Methods The gene expression profile 36 their corresponding clinical data were obtained from Cancer Genome Atlas (TCGA) Gene Expression Omnibus (GEO). Stepwise regression R with both directions was used to construct a model for prognosis Univariate Cox survival analysis...
Abstract Tumor metastasis involves cells migrating directionally in response to external chemical signals. Reactive oxygen species (ROS) the form of H 2 O has been demonstrated as a chemoattractant for neutrophils but its spatial characteristics tumor microenvironment and potential role cell dissemination remain unknown. Here we investigate ROS distribution 3D spheroids identify concentration gradient spheroid periphery, which projects into microenvironment. We further reveal induce...
Metal-free, photoredox-catalyzed aromatization-driven deconstructive functionalization of spiro-dihydroquinazolinones with α-CF 3 alkenes is achieved high chemoselectivity. Mechanistic studies suggest a radical pathway for this cascade reaction.
Abstract Developing highly efficient nonprecious heterogeneous catalysts for the cycloaddition of carbon dioxide (CO 2 ) to cyclic carbonates is crucial but challenging in modern chemical industry. Here, a facile and scalable molecules‐confined pyrolysis approach demonstrated synthesis nitrogen‐coordinated transition‐metal (TM) single‐atom (SACs). Moreover, various coordination structures metal centers forms nitrogen species are successfully revealed. The designed TM SACs show excellent...
The cycloaddition of CO2 with epoxides to synthesize cyclic carbonates is a crucial but challenging process. In particular, the co‐catalyst required for higher yields in this reaction inevitably dissolves organic solvents, resulting product impurities and solvent‐related hazards. Therefore, heterogeneous catalyst that delivers high under solvent‐free co‐catalyst‐free conditions highly desirable. study, we propose controlled pyrolysis strategy develop metal‐organic framework‐derived...
Photoredox‐catalyzed aromatization‐driven deconstructive thiolation and selenylation of spiro‐dihydroquinazolinones are presented. This method, which involves C‐C bond cleavage C‐S or Se formation, provides a facile approach to synthesizing remote site‐specific thiolated selenated quinazolin‐4(3H)‐ones with good yields functional group compatibility. A probable radical pathway is proposed for this transformation.
Abstract Background Evobrutinib, a third-generation Bruton's tyrosine kinase (BTK) inhibitor, shows great promise for treating neuroinflammatory diseases due to its small molecular size, ease of absorption, and ability cross the blood–brain barrier. Although previous studies have confirmed significant BTK expression in microglia, potential Evobrutinib treat ischemic stroke by modulating microglial function underlying mechanisms remain be elucidated. Methods Male C57BL/6 mice with cerebral...
Abstract Objective This study aimed to determine whether the RNA, 5‐methylcytosine (m5C), is involved in progression of head and neck squamous cell carcinoma (HNSCC). Materials methods We used least absolute shrinkage selection operator establish a prognostic score (PS) model based on m5C regulator expression. Immune scores were calculated using estimation stromal immune cells malignant tumor tissues expression data. The biological functions regulator, NOP2/Sun RNA methyltransferase 3...
Abstract Cells constantly sense and respond to not only biochemical but also biomechanical changes in their microenvironment, demanding for dynamic metabolic adaptation. ECM stiffening is a hallmark of cancer aggressiveness, while survival under substrate detachment associates with poor prognosis. Mechanisms underlying this, non‐linear mechano‐response tumor cells may reveal potential double‐hit targets cancers. Here, an integrin‐GSK3β‐FTO‐mTOR axis reported, that can integrate stiffness...
Triple negative breast cancer (TNBC) has the highest recurrence, metastasis and mortality rate of all subtypes, due to its typically more aggressive characteristics lack effective targeted treatment options. The Hippo pathway is a signaling cascade composed group conserved kinases, which serves an important role in almost types. Both circular RNAs (circRNAs) microRNAs (miRNAs) are types non‑coding RNAs, influence progression. CircRNAs have been demonstrated serve as miRNA 'sponges', binding...
(Lingzhi) polysaccharide peptide (GL-pp) is a component of the globally acknowledged traditional Chinese medicine
To explore the early neurodevelopmental features of young children with SYNGAP1 variants and their genotype-phenotype correlation.
Background This study aims to investigate the incidence and prognosis of malignancy in individuals with thrombospondin type-1 domain-containing 7A (THSD7A)-associated membranous nephropathy (MN).
Abstract As a kind of photoluminescent material, Cu I complexes have many advantages such as adjustable emission, variable structures, and low cost, attracting attention in fields. In this work, two novel two‐coordinate ‐N‐heterocyclic carbene were synthesized, they exhibit unique dual emission properties, fluorescence phosphorescence. The crystal structure, packing mode, photophysical properties under different conditions systematically studied, proving the emissive mechanism to be locally...
As an important member of the kindlin family, fermitin family 1 (FERMT1) can interact with integrin and its aberrant expression involves multiple tumors. However, there are few systematic studies on FERMT1 in pancreatic carcinoma (PAAD). We used several public databases to analyze level clinicopathological characteristics PAAD. Meanwhile, correlation between diagnostic prognostic value, methylation, potential biological function, immune infiltration, sensitivity chemotherapy drugs PAAD...