A5100387232- Glaucoma and retinal disorders
- Tuberculosis Research and Epidemiology
- Ophthalmology and Eye Disorders
- Pharmacogenetics and Drug Metabolism
- Traumatic Brain Injury and Neurovascular Disturbances
- Drug Transport and Resistance Mechanisms
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Pharmacological Effects of Natural Compounds
- Corneal surgery and disorders
- Retinopathy of Prematurity Studies
- Spinal Fractures and Fixation Techniques
- Magnolia and Illicium research
- Immune Response and Inflammation
- Traditional Chinese Medicine Analysis
- Clinical Laboratory Practices and Quality Control
- Intraocular Surgery and Lenses
- Inflammation biomarkers and pathways
- Antimicrobial Resistance in Staphylococcus
- Psoriasis: Treatment and Pathogenesis
- Hypothalamic control of reproductive hormones
- Cardiac Arrest and Resuscitation
- Acute Myocardial Infarction Research
- Wound Healing and Treatments
- Pharmacological Effects of Medicinal Plants
- Sunflower and Safflower Cultivation
Capital Medical University
2015-2025
Beijing Chaoyang Emergency Medical Center
2025
Jilin Agricultural University
2024
Beijing Hospital of Traditional Chinese Medicine
2016-2023
Shandong University
2023
Shandong Normal University
2023
Beijing Chao-Yang Hospital
2013-2023
Beijing Tongren Hospital
2008-2023
Beijing Chest Hospital
2022-2023
Children’s Hospital of Fudan University Xiamen Branch
2021
Neuroinflammation is an important host defense response to secondary brain injury after intracerebral hemorrhage (ICH). Triggering receptor expressed on myeloid cells 2 (TREM2) confers strong neuroprotective effects by attenuating neuroinflammation in experimental ischemic stroke. Recent studies suggest that apolipoprotein E (apoE) a novel, high-affinity ligand of TREM2. This study aimed investigate the TREM2 activation and neuronal apoptosis mouse model ICH.
The goal of this study was to explore the feasibility and accuracy using a wearable mixed-reality holographic computer guide external ventricular drain (EVD) insertion thus improve on classic freehand method for EVD insertion. authors also sought provide clinically applicable workflow demonstration.
Intestinal epithelial barrier dysfunction is crucial in the pathogenesis of intestinal and systemic diseases. Ferulic acid (FA) possesses promising antioxidant activities. In a previous study, we demonstrated potentially protective effects FA against heat stress-induced IEC-6 cells. However, underlying mechanisms are unclear. The present study aimed to elucidate whether protects cells from via antioxidative mechanisms.IEC-6 were pretreated with prior hyperthermia exposure at 42 °C for 6 h,...
Intestinal barrier dysfunction is an important clinical problem in various acute and chronic pathological conditions. Ferulic acid (FA) can attenuate the intestinal epithelial dysfunction, however, underlying mechanism remains unclear. The present study aimed to uncover protective effect of FA on a Caco-2 cell model lipopolysaccharide (LPS) stimulation mechanism. cells were pretreated with then exposed LPS stimulation. function was evaluated by measuring trans-epithelial resistance (TER)...
<h3>BACKGROUND</h3> The bronchiolitis obliterans syndrome (BOS) remains the major constraint on long term success of lung transplantation. Neutrophils have been associated with fibrosing conditions and noted to be increased in bronchoalveolar lavage (BAL) fluid patients BOS. <h3>METHODS</h3> This study was undertaken examine neutrophil accumulation BAL fluid, airway wall parenchyma, as well levels interleukin (IL)-8 normal controls transplant recipients without Bronchoscopic examination...
Liver fibrosis is a reversible wound-healing response to acute or chronic liver injury that can progress cirrhosis and cancer. Finding new strategies for prevention management of urgently needed. It known hepatic stellate cell (HSC) the primary source extracellular matrix drives progression. Herein, we carried out comprehensive secretome profiling identify NMN-induced changes in secretory proteins found NMN suppressed secretion profibrotic protein oxidoreductase activated HSC (LX-2) cells,...
We investigated the potential benefit of using a local infusion low-dose and cold human albumin in ischemic rats as compared with systemic delivery.Stroke was induced rats, at 2 hours treatment groups received 0°C saline or 37°C infused into area.The infusion, which achieved hypothermic temperature (P<0.001), produced greatest reduction infarct volume best recovery neurological function.The area offered combination regional brain hypothermia administration, enhanced neuroprotection would be...
Our previous studies suggested that paeonol, the active constituent of traditional Chinese medicine Cortex Moutan, may be an effective treatment for inflammatory disorders. In present study, therapeutic potential paeonol on atopic dermatitis (AD) was investigated using animal and cell experiments. AD‑like lesions were induced by repeated application 1‑chloro‑2,4‑dinitrobenzene (DNCB) to shaved dorsal skin BALB/c mice, P815 cells used in vitro assays. The lesions, serum spleens mice analyzed...
Hydroxysafflor yellow A (HSYA) is an effective therapeutic agent for inflammatory diseases and autoimmune disorders; however, its regulatory effect on NLRP3 inflammasome activation in macrophages has not been investigated. In this study, we predicted the potential interaction between HSYA xanthine oxidase (XO) via PharmMapper inverse docking confirmed binding inhibition inhibitory test (IC 50 = 40.04 μ M). Computation illustrated that, HSYA-XO complex, was surrounded by Leu 648, 712, His...
Sepsis is reported to be an unusual systemic reaction infection, accompanied by multiple-organ failure. Sepsis-induced cardiomyopathy, defined as damages and dysfunction of the heart, essential in pathogenesis sepsis. Traditional Chinese formula, which has long been used improve situation patients through multitarget regulation, now gradually being complementary therapy. The present study aimed investigate effect Qiang-Xin 1 (QX1) a traditional herbal medicine designed for cardiac...
Cardiac dysfunction is a critical manifestation of sepsis-induced multiorgan failure and results in the high mortality sepsis. Our previous study demonstrated that traditional Chinese medicine formula, Qiang-Xin 1 (QX1), ameliorates cardiac tissue damage septic mice; however, underlying pharmacology mechanism remains to be elucidated. The present was aimed at clarifying protective QX1 formula on dysfunction. moderate sepsis model mice established by cecal ligation puncture surgery. Treatment...
TBI-166, derived from riminophenazine analogues, shows more potent anti-TB activity than clofazimine and is being assessed against tuberculosis (TB) in a phase IIa clinical trial China. Preclinical regimen studies containing TBI-166 will support the IIb trials of TBI-166. In present study, we compared efficacy three murine TB models an all-oral drug-resistant drug with bedaquiline (BDQ) pyrazinamide (PZA) first-line isoniazid (INH) rifampin (RFP) PZA (HRZ regimen), most effective reported...
Traditional Chinese medicine (TCM) theory believes that clearing heat and promoting dampness is the main treatment method for chronic gastritis. Coptis chinensis Franch. has effects of heat, detoxifying, anti-inflammatory; Magnolia officinalis var. biloba can be used to treat abdominal pain, cough, asthma. regulate balance intestinal microbiota inhibit inflammatory reactions.This study will verify therapeutic effect on gastritis, explore its mechanism through transcriptome...
Linezolid (LZD) was the first oxazolidinone approved for treating drug-resistant tuberculosis. A newly regimen combining LZD with bedaquiline (BDQ) and pretomanid (PMD) (BPaL regimen) is 6-month oral that effective against multidrug- extensively