A5100339224- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- Advanced MRI Techniques and Applications
- Sirtuins and Resveratrol in Medicine
- Radiation Dose and Imaging
- Endoplasmic Reticulum Stress and Disease
- Vascular Malformations Diagnosis and Treatment
- Intracerebral and Subarachnoid Hemorrhage Research
- Peripheral Nerve Disorders
- Acute Ischemic Stroke Management
- Cerebrospinal fluid and hydrocephalus
- Glioma Diagnosis and Treatment
- Cancer Mechanisms and Therapy
- Genetics and Neurodevelopmental Disorders
- Radiomics and Machine Learning in Medical Imaging
- Spinal Fractures and Fixation Techniques
- Neurosurgical Procedures and Complications
- Effects of Radiation Exposure
- Renal cell carcinoma treatment
- Streptococcal Infections and Treatments
- Congenital Heart Disease Studies
- Sphingolipid Metabolism and Signaling
- Wnt/β-catenin signaling in development and cancer
- Epigenetics and DNA Methylation
- Face Recognition and Perception
Fudan University
2025
Chinese PLA General Hospital
2013-2025
Capital Medical University
2014-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Gansu Provincial Center for Disease Control and Prevention
2020-2024
Capital University
2024
Nanchang University
2023
Beijing Chest Hospital
2022-2023
First Affiliated Hospital of Nanchang University
2023
Shandong University
2021
The goal of this study was to explore the feasibility and accuracy using a wearable mixed-reality holographic computer guide external ventricular drain (EVD) insertion thus improve on classic freehand method for EVD insertion. authors also sought provide clinically applicable workflow demonstration.
Abstract 3D histology, slice-based connectivity atlases, and diffusion MRI are common techniques to map brain wiring. While there many modality-specific tools process these data, is a lack of integration across modalities. We develop an automated resource that combines histologically cleared volumes with atlases MRI, enabling the analysis histological features multiple fiber tracts networks, their correlation in-vivo biomarkers. apply our pipeline in murine stroke model, demonstrating not...
Invasion and metastasis of glioblastoma-initiating cells (GICs) are thought to be responsible for the progression recurrence glioblastoma multiforme (GBM). A safe drug that can applied during rest period temozolomide (TMZ) maintenance cycles would greatly improve prognosis GBM patients by inhibiting GIC invasion. Resveratrol (RES) is a natural compound exhibits anti-invasion properties in multiple tumor cell lines. The current study aimed evaluate whether RES inhibit invasion vitro vivo....
OBJECTIVE The authors aimed to evaluate the technical feasibility of a mixed-reality neuronavigation (MRN) system with wearable head-mounted device (HMD) and determine its clinical application accuracy. METHODS A semiautomatic registration MRN on HoloLens smart glasses was developed tested for accuracy feasibility. Thirty-seven patients intracranial lesions were prospectively identified. For each patient, multimodal imaging–based holograms lesions, markers, surrounding eloquent structures...
Lipid nanoparticle (LNP)-based mRNA therapeutics, highlighted by the success of SARS-CoV-2 vaccines, face challenges due to inflammation caused ionizable lipids. These lipids can activate immune system, particularly when co-delivered with nucleic acids, leading undesirable inflammatory responses. We introduce a novel class anti-inflammatory functionalized hydroxychloroquine (HCQ), which suppresses both lipid-induced and acid-induced activation. HCQ-functionalized LNPs (HL LNPs) exhibit...
The resistance mechanisms that limit the efficacy of retinoid therapy in cancer are poorly understood. Sphingosine kinase 2 (SphK2) is a highly conserved enzyme mainly located nucleus and endoplasmic reticulum. Unlike well-studied sphingosine 1 (SphK1) cytosol, little has yet understood functions SphK2. Here we show SphK2 overexpression contributes to all-trans retinoic acid (ATRA) colon through rapid degradation cytoplasmic X receptor α (RXRα) by lysine 48 (K48)- 63 (K63)-based...
Abstract Colorectal cancer (CRC) is a typical and lethal digestive system malignancy. In this study, we investigated the effect of sirtuin 3 (SIRT3) expression, fidelity mitochondrial protein, on proliferation CRC cells mechanisms involved. Using University Alabama at Birmingham Cancer Data Analysis Portal database Clinical Proteomic Tumour Consortium database, discovered that low expression SIRT3 in was negative factor for survival prognosis ( P < .05). Meanwhile, correlated with distant...
This study aimed to investigate whether diffusion-weighted imaging (DWI) could contribute the discrimination between benign and malignant renal cancer.We searched PubMed electronic database for eligible studies. STATA 12.0 software was used statistical analysis. The SMD 95% CI were calculated.Decreased ADC signal seen in all cancer patients (cancer tissue versus normal tissue: = 1.63 0.96~2.29, P < 0.001; 2.22 1.53~2.90 0.001, resp.). MRI machine type-stratified analysis showed that...
Bedside freehand catheter insertion for the treatment of basal ganglia hemorrhage currently remains major method due to its simplicity and efficiency, but it is associated with low precision. We retrospectively evaluated feasibility accuracy using a wearable mixed-reality holographic computer guide catheter-based compared method. collected 30 patients who initially underwent either guided (holographic guidance group) or (freehand group). Data pre- postoperative CT images in both groups...
Diffuse axonal injury (DAI) disrupts the integrity of white matter microstructure and affects brain functional connectivity, resulting in persistent cognitive, behavioral affective deficits. Mounting evidence suggests that altered cortical-subcortical connectivity is a major contributor to cognitive dysfunction. The striatum particularly vulnerable DAI, but has received less attention. This study aimed investigate alteration patterns striatal subdivision connectivity. Twenty-six patients...
Knowledge of the plasticity language pathways in patients with low-grade glioma is important for neurosurgeons to achieve maximum resection while preserving neurological function. The current study sought investigate changes ventral located regions likely affect dorsal pathways. results revealed no significant difference fractional anisotropy values arcuate fasciculus between groups or hemispheres. However, and lateralization index left inferior longitudinal fronto-occpital were higher than...
Eighty group G streptococcal stains were collected from Chinese children. Susceptibility testing was done by a double-dilution and disk diffusion method. PCR used to test drug-resistant genes, the χ(2) definite probability methods for statistically significant differences among three groups. Thirty-four isolates (42.5%) showed resistance erythromycin. There are between characteristics of streptococci different regions China.
The functional profiles of regions in the ventral occipital-temporal cortex (VTC), a critical region for object visual recognition, are associated with VTC connectivity patterns to nonvisual relevant corresponding domain. However, whether and how whole-brain connections affect recognition behavior remains untested. We directly examined necessity by testing 82 patients whose lesion spared but affected various white matter (WM) tracts other regions. In these patients, we extracted anatomical...