A5013004572- Epigenetics and DNA Methylation
- Pluripotent Stem Cells Research
- Mitochondrial Function and Pathology
- Glioma Diagnosis and Treatment
- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Cerebrospinal fluid and hydrocephalus
- Neurosurgical Procedures and Complications
- Chromatin Remodeling and Cancer
- MRI in cancer diagnosis
- Vascular Malformations Diagnosis and Treatment
- Fetal and Pediatric Neurological Disorders
- Intracerebral and Subarachnoid Hemorrhage Research
- Meningioma and schwannoma management
- Cancer Genomics and Diagnostics
- Surgical Simulation and Training
- Histone Deacetylase Inhibitors Research
- Cancer, Hypoxia, and Metabolism
- Protein Degradation and Inhibitors
- Autophagy in Disease and Therapy
- Augmented Reality Applications
- Neurofibromatosis and Schwannoma Cases
- Intracranial Aneurysms: Treatment and Complications
- Head and Neck Surgical Oncology
- Peripheral Nerve Disorders
Chinese PLA General Hospital
2014-2025
Ningxia Medical University
2023
Shanghai Industrial Technology Institute
2022
Harbin Engineering University
2021
Hainan General Hospital
2020-2021
Tri-Service General Hospital Songshan Branch
2020
State Key Laboratory on Integrated Optoelectronics
2019
Jilin University
2019
Chinese People's Liberation Army
2013-2016
OBJECTIVE The goal of this study was to investigate the effectiveness and practicality endoscopic surgery for treatment supratentorial hypertensive intracerebral hemorrhage (HICH) compared with traditional craniotomy. METHODS authors retrospectively analyzed 151 consecutive patients who were operated on HICH between January 2009 June 2014 in Department Neurosurgery at Chinese PLA General Hospital. Patients separated into an endoscopy group (82 cases) a craniotomy (69 cases), depending they...
Low levels of reactive oxygen species (ROS) are crucial for maintaining cancer stem cells (CSCs) and their ability to resist therapy, but the ROS regulatory mechanisms in CSCs remains be explored. Here, we discover that prohibitin (PHB) specifically regulates mitochondrial production glioma stem-like (GSCs) facilitates GSC radiotherapeutic resistance. We find PHB is upregulated GSCs associated with malignant gliomas progression poor prognosis. binds peroxiredoxin3 (PRDX3), a...
Glioblastoma (GBM) is the deadliest primary brain tumor and generally resistant to immunotherapy because of severe dysfunction T cells. Novel treatment options are critically needed overcome resistance GBM. Here we demonstrate that Zika virus (ZIKV) improves efficacy anti-PD ligand 1 (PD-L1) in We found ZIKV induces a strong pro-inflammatory response increases CD4+ CD8+ cell intratumoral infiltration activation GBM mouse models. mice bearing tumors inhibits growth prolongs survival. These...
OBJECTIVE The authors aimed to evaluate the technical feasibility of a mixed-reality neuronavigation (MRN) system with wearable head-mounted device (HMD) and determine its clinical application accuracy. METHODS A semiautomatic registration MRN on HoloLens smart glasses was developed tested for accuracy feasibility. Thirty-seven patients intracranial lesions were prospectively identified. For each patient, multimodal imaging–based holograms lesions, markers, surrounding eloquent structures...
The 2016 World Health Organization (WHO) Classification of Tumors the Central Nervous System (CNS) was revised to include molecular biomarkers as diagnostic criteria. However, conventional biopsies gliomas were spatially and temporally limited. This study aimed determine whether circulating tumor DNA (ctDNA) from cerebrospinal fluid (CSF) could provide more comprehensive information gliomas.Combined with clinical data, we analyzed gene alterations CSF tissues newly diagnosed patients,...
<p>Supplementary Figures S1 shows that GSCs produce high levels of phosphocreatine through upregulating CKB. Supplementary S2 ZEB1 promotes CKB transcription in GSCs. S3 knockdown impedes GBM growth. S4 disruption production S5 cCr treatment no side effect on mice. S6 binds to BRD2 and inhibits its ubiquitin mediated proteasomal degradation. S7 chromosome segregation GSC proliferation transcription. S8 biosynthesis by improves JQ1 therapeutic efficacy GBM.</p>
The infiltration of glioblastoma multiforme (GBM) is predominantly characterized by diffuse spread, contributing significantly to therapy resistance and recurrence GBM. In this study, we reveal that microtubule deacetylation, mediated through the downregulation fibronectin type III SPRY domain-containing 1 (FSD1), plays a pivotal role in promoting GBM infiltration. FSD1 directly interacts with histone deacetylase 6 (HDAC6) at its second catalytic domain, thereby impeding activity on...
<p>Supplementary Figures S1 shows that GSCs produce high levels of phosphocreatine through upregulating CKB. Supplementary S2 ZEB1 promotes CKB transcription in GSCs. S3 knockdown impedes GBM growth. S4 disruption production S5 cCr treatment no side effect on mice. S6 binds to BRD2 and inhibits its ubiquitin mediated proteasomal degradation. S7 chromosome segregation GSC proliferation transcription. S8 biosynthesis by improves JQ1 therapeutic efficacy GBM.</p>
Hypertensive intracerebral haemorrhage (HICH) is the most common form of haemorrhagic stroke with highest morbidity and mortality all types. The choice surgical or conservative treatment for patients HICH remains controversial. In recent years, minimally invasive surgeries, such as endoscopic evacuation stereotactic aspiration, have been attempted haematoma removal offer promise. However, research evidence on benefits aspiration still insufficient.A multicentre, randomised controlled trial...